Tobias Dick
@RedoxDKFZ
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Stay in touch with red ox science from the Dick lab in Heidelberg
Joined July 2020
Oxidative inactivation of GAPDH is a booster for reductive power. Tumor cells employ this mechanism to survive in the host and to resist therapy. Many thanks to our long-term collaborators @RalserLab, @MilsomMick & @pavlo_lutsik
https://t.co/6EhgB7kTzh
nature.com
Nature Metabolism - Human and mouse cells expressing a redox-insensitive GAPDH mutant that otherwise retains its catalytic activity are shown to be unable to upregulate the oxidative pentose...
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"In the Pipeline" @ScienceMagazine: Derek Lowe reflects on “Weird Little Sulfur Groups”, inspired by our new paper on protein persulfidation @nchembio
https://t.co/JhXWA7deHV
https://t.co/uC514nktr2
science.org
Weird Little Sulfur Groups
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We are looking for a new #PhD student to work on #persulfides and their role in #ferroptosis, as part of @Ferroptosis2306. #PhDposition #RedoxBiology #ChemicalBiology #DKFZ #UniHeidelberg
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Congrats to @PrattGroup
@RedoxDKFZ
@almut_schulze
@AngeliFriedmann for discovering the role of hydropersulfides and other sulfane sulfur compounds in #ferroptosis -- My thoughts about sulfur and the brain are here: https://t.co/0YvIq37iD4
brentstockwell.medium.com
A conversation starter for your next party: sulfur may help your brain.
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Happy to write this @CellChemBiol Spotlight with @MikeLangePhD highlighting recent exciting work from @RedoxDKFZ, @PrattGroup, and colleagues. Their findings reveal a role for hydropersulfides as endogenous antioxidants that inhibit ferroptosis! 👏🎉🤩 https://t.co/FzzGee7Fpq
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News and Views @nchembio: Jon M. Fukuto discussing new insights into the cytoprotective roles of hydropersulfides: "A radical way to avoid cell death" https://t.co/XVcYlOm7ap
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How stressed tumor cells escape cell death: Scientists at the German Cancer Research Center have now discovered a new mechanism by which normal as well as #cancer cells protect themselves against ferroptosis. @RedoxDKFZ ➡️ https://t.co/zJkdUNYSq6
dkfz.de
Because of their highly active metabolism, many tumors are susceptible to a special type of cell death, ferroptosis. Nevertheless, cancer cells often manage to escape this fate. Scientists at the...
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Great to see mutually confirming and complementary research on hydropersulfides as outstanding radical scavengers from @PrattGroup @J_A_C_S along with our's @RedoxDKFZ @nchembio. https://t.co/Wf68qHNFEG
pubs.acs.org
Hydropersulfides (RSSH) are believed to serve important roles in vivo, including as scavengers of damaging oxidants and electrophiles. The α-effect makes RSSH not only much better nucleophiles than...
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All across biology, cells produce hydropersulfides (RSSH). But why? We found them to scavenge free radicals and protect biomembranes @nchembio. Many thanks to our collaborators @AngeliFriedmann @Ferroptosis2306 @almut_schulze @DrugDiscov_DKFZ @graeter_mbm
https://t.co/NPQnqunvLE
nature.com
Nature Chemical Biology - Enzymatically generated sulfane sulfur species called hydropersulfides terminate free radical chain reactions to prevent oxidative membrane damage and ferroptosis induction.
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If you want to detect protein persulfides you need to trap them first… here we share a story that started with puzzling observations and led to new insights into the behavior of alkylating agents. Thanks to @DrugDiscov_DKFZ for the nice collaboration. https://t.co/TX46JuulMo
onlinelibrary.wiley.com
Detection and quantitation of protein persulfides requires trapping with alkylating agents. Persulfide adducts derived from commonly used alkylating agents are unstable under biologically relevant...
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N-acetylcysteine (NAC) is widely used as an "antioxidant". But do we understand what it is doing inside cells and organisms? Check out our review, by @Brandanium, @Vladi76320028 and Daria, now at @MessensLab:
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Specific redox signaling needs a scaffold. Check out our new paper on the Prx2-STAT3 redox relay... @NatureComms
https://t.co/z0fHl6jtRu
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Thank you, Ari, Bruno and Madia @Udelaruy for writing an insightful commentary on our recent peroxiredoxin paper. https://t.co/XQXa18Q2Na
pnas.org
In vivo observation of peroxiredoxins oligomerization dynamics
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If you are interested in the highly dynamic quaternary structure of peroxiredoxins, take a look at our new paper... https://t.co/R5H6Ua1GcE
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