Check out our paper on proton pump inhibitor activation in cells in @NatureChemistry. Congrats to first author Teresa Marker who started this project in my group and finished it with Tobias Dick (@RedoxDKFZ). More collabs between our groups @DKFZ to come!

Off to #efmcismc24 in Rome. Looking forward to great science and meeting new and old friends.

Quick question for the #PROTAC #TPD aficionados out there. Is there a documented first written use of the term "linkerology"? Do we know who coined the term?.

Winner of the worst bar graph competition

We are hiring! We are seeking a creative chemist to join our research group at the German Cancer Research Center as a postdoc. Are you interested in medicinal chemistry, targeted protein degradation, and cancer research? Please spread the word and apply.

They say lightning never strikes twice? Former PhD student @RRSteimbach proves them wrong by winning his 2nd PhD prize, this time from the EFMC-YSN @YoungSciNet. Come see his lecture in Rome at #EFMC_ISMC in Sept. Congratulations, Raphael!

It's great to visit Denmark for the first time with the opportunity to present our groups' work at the University of Copenhagen. Thanks @ChristianAOlsen for the invitation!.

Congratulations to former PhD student @RRSteimbach for winning a Dissertation Prize from the MedChem division of the @GDCh_aktuell. Well deserved!

Open heart surgery on the 400.

It was interesting to note, after we completed the depicted analysis, how many heavy atoms are added individually. Four contiguous atoms via CO, methylene Wittig, CH2O, and TFANH2.

Which classic total synthesis did we study today?

German word of the day: Weltraumwetterprognosezentrum. Thanks, solar flare!.

After a full day of Targeted Protein Degradation at #BarcelonaBioMed, it was time for some Targeted Pavement Degradation with the locals. Skatepark Mar Bella delivered a highly potent and selective experience.

Please join us in Braunschweig at the HZI next month for the Helmholtz Drug Discovery Conference! With a program of excellent speakers and slots available for short talks selected from abstracts (deadline April 15th), you won't want to miss it.

It’s not often I have the chance to rival @disney_lab’s regular postings, but last weekend’s getaway to Carcans Plage finally gave me one.

Please join us in Braunschweig on May 15th-16th for the Helmholtz Drug Discovery Conference #HDDC2023. We have a fantastic lineup of international speakers, and opportunities for selected oral talks and posters from submitted abstracts. Register at

Congratulations to @RRSteimbach for completing his PhD with an excellent defense last week. We will miss you dearly and wish you all the best of luck in your future scientific journey.

Respect.

and

M.G. Finn has spoken. In summary (with his permission): 1. Ascorbate should be fine for disulfides. 2. TCEP should always be avoided as it can somewhat inhibit CuAAC (surprising to me!). Here are links to two useful references from his lab. 👇.