RCNS MedChem Research Group
@keserulab
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Medicinal Chemistry Research Group at the HUN-REN Research Centre for Natural Sciences, headed by György M. Keserű. Also on Mastodon: @[email protected]
Budapest, Hungary
Joined April 2021
RT @NatRevDrugDisc: The changing landscape of medicinal chemistry optimization This new article analyses oral drug….
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Our paper on allosteric, covalent STAT inhibitors was highlighted in the "Recent article highlights" of @ACSMedChemLett.
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We are happy to welcome Tamás Dobai from the Institute of Parasitology in České Budějovice, Czechia, who will be working with us for the next months on the computational modeling of parasitic enzymes.
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Rounding off an incredible streak, Levente Kollár is our third junior colleague to successfully defend his PhD thesis in the past two weeks, with full points from the on-site committee! Congratulations to all three of you, we’re super-proud! 👏
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We congratulate our colleague, Dénes Szepesi Kovács, for his successful PhD defense! (Overwhelming support from the on-site Doctoral Committee, final decision by the Univ. Doctoral Board later this year.) 👏
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We congratulate our colleague, Nikolett Péczka, for her successful PhD defense! 👏Full points from the on-site Doctoral Committee, final decision by the Univ. Doctoral Board later this year.
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Our colleague, Dávid Bajusz, was appointed as a member of the Hungarian Young Academy:
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In our recent work, we have utilized a scarcely-studied #allosteric site of STAT3 to design new covalent inhibitors.
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Following our recent review on #fluorescent probes for #GPCRs, our latest paper details an interesting case study of the M2 receptor.
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Our latest review in Eur J Pharm Sci summarizes recent advances (2018–2024) in #fluorescent probe development for Class A #GPCRs, analyzing over 120 newly developed probes covering 60 GPCRs.
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How do affinity and reactivity shape covalent target engagement? In our latest paper in J Med Chem, we show the distinct advantages of lead-like compounds vs. fragments in TCI design. #CovalentDrugs #MedicinalChemistry #DrugDiscovery.
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Our new photoaffinity labelling technology ( is published in @angew_chem. It is more biocompatible, more efficienct, cheaper and easily accessible, even as a late-stage modification. We are working with @EnamineLtd to make it available for the community.
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We are happy to welcome Elisa Patacchini from the Sapienza University of Rome, who will be working with us for the next months on the computational modeling of GPCR ligands.
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Our work on the benchmarking of uHTVS workflows against DEL libraries was featured on the cover of JCIM @JCIM_JCTC.
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Our joint work with the Martinek group of @Uni_Szeged on local surface mimetics was featured on the cover of @angew_chem!
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Check out our latest paper on the role of the water network in protein-ligand binding. Fantastic collaboration with our colleagues from @pte1367 and Univ. Ljubljana. @janezilas
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In the past three days, we have presented our activities to the curious visitors of the first Science Expo exhibition in the magnificent Museum of Fine Arts, Budapest. Thanks for our fantastic PhD students for their volunteer work!
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Check out our latest paper with @SonjaPeter4, @Chris_de_Graaf, @ALLODD_ITN, @NxeraPharma, on the systematic annotation and ligandability assessment of allosteric GPCR binding sites.
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On September 27, we have participated in the annual Researchers’ Night, a national outreach programme for bringing science closer to students. Hats off to our curious participants who have contributed to the identification of new candidate compounds for cancer therapy!
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In our latest paper, we are benchmarking uHTVS tools against published DEL datasets of different magnitudes. More details in
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