Grubb Lab
@GrubbLab
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Our lab is interested in brain development, especially those processes of neuronal maturation which are shaped by electrical activity.
London, England
Joined April 2018
When axons regrow after injury, how do they get their presynaptic terminals working again? Answer is: really quickly! Out now from us in @CellReports, led by the structure-function DreamTeam that is @LorcanBrowne & @ACrespoVieira ⤵️ https://t.co/Hd73rT3ett (1/6)
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📣ALBA & @ELSneuroscience invite you to nominate a neuroscientist who works in a country underrepresented among neuroscience publications/conferences, and is actively committed to DEI work in the field. Winner gives a talk at #FENS2024! 👉🏽 https://t.co/oNsaN83ttj 🗓️ 20 Oct 2023
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Very excited to announce that the lab has a website! https://t.co/IsSAGBj3HK Check it out for information about the type of work we plan to do and the type of lab we plan to be. @dev_neuro @dkneurolab
dkneurolab.com
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The Brave Little Neuron was formed by a group of friends who wanted to share their scientific #research and make #neuroscience accessible for everyone. Look out for their workshop @EinsteinsGarden @GreenManFest on Friday. @MRC_CNDD @KingsIoPPN @pheereynolds #BraveLittleNeuron
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I'm thrilled to share our preprint from the Fleischmann lab! We find molecular signatures of ancestral cortical neurons in the mammalian olfactory cortex. @AlonsoOrGu @spinar_d @davidhbrann @Lab_Tali_Kimchi @Datta_Lab @matosches
@CarneyInstitute
https://t.co/DshAAmrbVr
biorxiv.org
The cerebral cortex diversified extensively during vertebrate evolution. Intriguingly, the three-layered mammalian olfactory cortex resembles the cortical cytoarchitecture of non-mammals yet evolved...
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Keep an eye out for @pheereynolds @fmferreira_ @JuchaMoore, me and more in @EinsteinsGarden! #BraveLittleNeuron #SciComm
In one week our Brave Little Neuron team will be heading to @GreenManFest! They are all completing PhDs @dev_neuro @CNDD @KingsIoPPN @KingsCollegeLon in topics including visual system, foetal brain development, schizophrenia and depression. @EinsteinsGarden #BraveLittleNeuron
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Yes! This is going to be a fantastic adventure, with @NeuroBender and @neuronJoy along for the ride too!
Had to read the email 4 times at least…but it’s official! I’ve just got a Wellcome Trust Early Career Award to work on axodendritic interactions during development, a dream coming true! That also means that @GrubbLab and I will be working together for a looooong time 😁
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Amazing job! And all achieved in the face of sustained PI laboratory 'assistance'...
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Great paper, yet another proof that the fixation you use for your staining can make a huge difference: just look at figures 2 and 7! https://t.co/00pKRDvpbK
science.org
Glyoxal enhances antibody penetration and antigenicity in neural tissues, making any antigen-exposing techniques unnecessary.
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Fantastic 'Impaired Airs' meeting @KingsCollegeLon today, superbly organised and chaired by @rowanrobo as part of the @AnosmiaHistory project. Thanks to all who participated, including @SAHowardSmith, @WillTullett, @chriskelly151 and many talented others - I learnt so much!
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A #NewPI, will I ever be able to recruit an overseas postdoc? First BREXIT, then visa fees going even more insane! 99.9% of the people in my sub-field do not have a British passport!
The UK is planning on massively increasing visa costs. Currently a researcher looking at a 5-year Global Talent Visa, together with their partner and two children, needs to find £13.4k. All up front. A big ask. But that’s now slated to increase to… **£20.9k**
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The efforts and cost required for a lab member to get a visa to visit collaborators in the UK has been crazy. And it is also supremely humiliating for the applicant. Good luck with remaining competitive with such conditions.
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#FluorescenceFriday courtesy of our work experience student Lily Burke! Stunning dopaminergic neurons and NGF in the olfactory bulb
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As an academic writing coach, here are the 7 mistakes I see supervisors and PIs make in the process of co-writing a paper with their PhD students or mentees. A thread. 🧵 #AcademicTwitter #PIchat #newPI
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📣Fully funded postdoc position available in my lab @dev_neuro at King’s College London! This is a very exciting project focused on the development and regenerative potential of human choroid plexus using organoids!🧠 (Please RT🙏) Apply here:
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Just getting started in #patchclamp #electrophysiology? Then our latest #Neurowire article '10 common patching problems and how to fix them - a guide for beginners' by @emily_winson, @GrubbLab will help! https://t.co/Vxp1MnQNgO
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Synaptic elimination is essential for neural development. Our new study in mitral cells explains how neurons prune all but one type of synaptic input through synaptic competition. Open access in @Dev_Cell
https://t.co/SvXO4Pmb2D (1/7)
cell.com
Fujimoto, Leiwe, Aihara, et al. show that strong glutamatergic inputs to a dendrite trigger local protection and lateral inhibition via NMDARs and RhoA, leading to the pruning of all but just one...
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🔥 new position open now!
Come work with @LignaniLab_UCL @s_schorge and the rest of us on gene therapy for epilepsy https://t.co/1mPY2KXLFP
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So finally my first ever (!!!) first author is out into the world of BioRxiv summarising my PhD work - Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy. Twitter 🧵 below https://t.co/Gi8paMbbkP
biorxiv.org
Synapse loss is currently the best biological correlate of cognitive decline in Alzheimer’s disease and other tauopathies. Synapses seem to be highly vulnerable to tau-mediated disruption in neurod...
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One feels so small at the Greenwood Theatre! Nice venue for the @KingsCollegeLon School of Neuroscience Symposium, excellent talks and questions!
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Importin 13-dependent Axon Diameter Growth Regulates Conduction Speeds along Myelinated CNS Axons https://t.co/ojRWf2AtlG
#biorxiv_neursci
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