Kira Gritsman
@Gritsman_lab
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Physician-scientist investigating signaling and self-renewal in leukemia and hematopoietic stem cells. Posts are my own.
Bronx, NY
Joined September 2011
So excited to congratulate our MSTP student Daniel Borger, who was mentored by Paul Frenette and myself, on a successful thesis defense! @EinsteinMSTP @EinsteinPhD @EinsteinCellBio @Einstein_SCI
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Kudos to @aditishasMD for organizing our Einstein-Montefiore team at the Move for MDS event this morning in Battery Park and for her inspiring speech! The rain didn’t stop us!
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My institute @EinsteinMed kindly featured our recent paper presenting a new model for regulating hematopoietic stem cell numbers.👇Many thanks for showcasing our work so clearly! @SteidlUli @Gritsman_lab @EinsteinCellBio @Einstein_SCI
https://t.co/udEwFxPAeY
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So proud to be part of this study as the first and co-corresponding author!👇 @EinsteinCellBio, @Einstein_SCI, @EinsteinMed
Nature research paper: Haematopoietic stem cell number is not solely defined by niche availability https://t.co/MCeMEImwaT
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Please check out this thread on our latest paper in @Nature on HSC pool size regulation. https://t.co/hJLrLYXXEG Phenomenal collaboration with the one and only @Gritsman_lab, and driven by the outstanding @ShoTakeishi! @EinsteinCellBio @Einstein_SCI @EinsteinMed
Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb
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Very happy to contribute together with @SteidlUli to this exciting project that began in Paul Frenette’s lab- a tour de force by the amazing @ShoTakeishi! Please check out this thread 👇
Excited to share our latest work @Nature! We show that the total number of hematopoietic stem cells (HSCs) in the body is restricted, challenging the classical model that HSC numbers are determined locally by the niche and introducing a new paradigm. (1/9) https://t.co/kvFqNQ8Nxb
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Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature https://t.co/r1bXqfpPSU and terrific editorial from Dennis Lo
science.org
The cells could be a new source of tumor DNA for liquid biopsies
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @ScienceMagazine! 🎉 🧽 📖 Read our paper here: https://t.co/CvYSNq2nHj 🎬 Watch a summary: https://t.co/qvuZR3reTj 🧵 Or keep reading for the key points! 🔑 1/19
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We are excited to announce that The Myeloid Workshop is back on under ASH this year and will be held on Friday, Dec 5, from 3-7PM. ...👇
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In our study just published in @BloodCancerJnl Outdoor Air Pollution(OAP) , particularly PM2.5 was associated with a trend towards worse survival in #multiplemyeloma patients treated in a historically redlined area - Bronx, NY. @Einstein_SCI @MontefioreNYC @EinsteinMed
Fine particulate matter exposure is linked to worse myeloma outcomes in a diverse urban cohort | Blood Cancer Journal @aditishasMD
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We are very excited to officially launch our single cell proteomics service!! Please, check out our website if you want to work with us! https://t.co/3beLRHphKU
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Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @TheHematoPoet and the whole team
So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @Gritsman_lab
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Our trainees had a truly enriching experience at #KUHRTN2025 at @EmoryMedicine, Atlanta! They gained insights into career development, received valuable advice, and enjoyed connecting with field leaders and peers (@KUHR_Trainees) from across the country. https://t.co/C7OYWL4l4m
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Congratulations to @SteidlUli on this very well deserved honor!
Congratulations to Ulrich G. Steidl, M.D., Ph.D., who is our 14th Annual Marshall S. Horowitz Faculty Lecturer. @EinsteinMed @MontefiorePeds @RFK_Center @i_jsmiles @EinsteinPHPM
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So excited that our collaboration with @DShechter on a targetable PTM - glutamylation - on NPM1c in AML, led by @AlexSchurer and @HumairaIlyas8 is now on BiorXiv!
We discovered a new AML vulnerability: TTLL4 glutamylates NPM1c and helps leukemia cells thrive. Knock it down and cells differentiate and survival improves. Collab between our lab and @Gritsman_lab—funded by NIH and DoD/CDMRP. Preprint: https://t.co/LXolM4wyXY /1
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About a month after Donald Trump took office as the 47th US president, almost all grant-review meetings remain suspended at the US National Institutes of Health (NIH), preventing the world’s largest public funder of biomedical research from spending much of its US$47 billion
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🔥 Excited for our Phase 1 study Ven + 7+3 for Newly Diagnosed AML demonstrating 85% CR (86% MRD-neg) @BloodJournal @ MontefioreNYC @EinsteinMed @MontefioreNYC Eric J. Feldman @MendelGoldfing2
@mkonople @Amitvermamds @aditishasMD @Gritsman_lab
#leusm
https://t.co/tcGDSCQCFD
ashpublications.org
Key PointsVen can be safely used in combination with 7+3 chemotherapy for remission induction in patients with newly diagnosed AML.Ven plus 7+3 chemotherap
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Really looking forward to this meeting!
I feel like we could all use something fun to look forward to right about now 👇 Abstract submission and registration are open for the FASEB Hematologic Malignancies meeting. This is always the BEST meeting!!! Please RT! https://t.co/cBjeA2eyXv
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🚨Apparently all NIH Study Sections have been suspended indefinitely. For those who don’t know, this means there won’t be any review of grants submitted to NIH Depending on how long this goes on for, this could lead to an interruption in billions in research funding.
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Excited to share our latest contribution describing the role of inflammation in regulating defective hematopoiesis in RUNX1-familial platelet disorder & identifying CD74/mTORC/JAK axis as one of the drivers of inflammation @ScienceTM @OHSUKnight @OHSUNews
https://t.co/8uj9rWkWH0
science.org
CD74 signaling drives inflammation and differentiation defects in hematopoietic stem and progenitor cells in RUNX1-familial platelet disorder.
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Check out the talk by my amazing grad student, @GhezziIan this morning at #ASH2024. Using a novel mouse model, he’s been able to identify a rare population of dormant JAK2-mutant HSCs that drive disease propagation and therapy resistance in MPNs.
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