Sergei Doulatov
@Doulatov_lab
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Stem cell lab at Columbia University Medical Center studying hematopoiesis and myeloid malignancies.
New York, USA
Joined June 2013
Excited to share our latest work in Blood Cancer Discovery @BCD_AACR. We discover that SF3B1-mutated human HSCs are sensitized to CHK1 inhibitors due to pervasive mis-splicing of mitotic regulators. Led by @MartinaSarchi, with Luca Malcovati & @bradleybio.
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Our lab at Columbia University is hiring a lab manager! If you are passionate about driving new discoveries and therapies for blood stem cells and cancers, we hope to hear from you!! DM me any questions and apply here: https://t.co/a3f2nqxshP
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New #hematopoiesis research maps single-cell dynamics of endothelial-to-hematopoietic transition from iPSCs and integrates it with human embryo datasets to identify ligand-receptor interactions that drive developmental regulation. https://t.co/kescyDxm35
@UW @fredhutch @UWISCRM
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On my way to Japan for @ISEHSociety #ISEH2025 and the iPSC-hematopoiesis symposium, already in its fourth year! Still time to register (for free) to learn the latest and greatest on engraftable iPSC hematopoiesis and join our rooftop party! 🎉 #iPSCLove
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Led by @rachcwellington, @ChelseaCheng16, fantastic collaboration with Raquel Espin-Palazon, @coletrapnell, & Brandon Hadland. Lots of new data in the published version. You can also interactively explore the single cell atlas here:
cellxgene.cziscience.com
Find, download, and visually explore curated and standardized single cell datasets.
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Our study is now published online in @stemcellreports! We map how blood forms from hemogenic endothelium during iPSC differentiation and identify FGF signaling as a barrier to hematopoiesis. https://t.co/SMJguIgrsM
cell.com
Wellington and colleagues mapped single-cell dynamics of hematopoietic specification from human iPSC hemogenic endothelium in comparison to the embryo. They identified modulable ligand-receptor...
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Just getting home after an incredible week at FASEB hematologic malignancies. This is truly the best meeting and I feel so lucky to be able to attend!! The week was too busy to actively post so here’s a little recap thread… #HEMSRC 🩸🔬
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Fabulous EHA/FASEB joint session on Immune System and Microenvironment this morning! Big thank you to @EHA_Hematology for their partnership!!! #HEMSRC
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#hemsrc Thank you to all of our panelists for the career development session at the FASEB hematologic malignancies meeting! Such great advice! Powered by gummy bears….
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Looking forward to welcoming everyone to the FASEB Heme Malignancies meeting on Sunday! As you are packing, we wanted to let you know that there is a gym, basketball court, and pool on site! Also, options for hiking at the brewery social event! 🏊♀️🏀🏋️♀️ Safe travels! #HEMSRC
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Need help finding your poster # for the FASEB Heme Malignancies Meeting? 🌟Direct link here: https://t.co/NlyJvQ1buf Odd numbers: Monday Even numbers: Tuesday Your poster will stay up for the whole conference, though so you can have discussions anytime! #HEMSRC
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Excited to share the first work from my post doc out today in @LeukemiaJnl!
Excited to share our latest study published in Leukemia (@LeukemiaJnl): Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome https://t.co/2hzmINxMQi
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Last chance to get your abstracts in for the FASEB Hematologic Malignancies Meeting!! All abstracts must be in by June 15. We’ve had an amazing turnout so far, @juliamaxson and I can’t wait to see you all in Southbridge! https://t.co/Gvajdatl7c
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Reminder to get your abstracts in for the FASEB Hematologic Malignancies Meeting by June 1st!!! The scientific program is awesome this year and we will have lots of career dev and networking activities!!!
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Calling all trainees to apply for travel awards for FASEB Heme Malignancies meeting!! Deadline is May 15. This is a fantastic small meeting to attend for early career scientists.
Don't forget to apply for travel awards for the FASEB Hematologic Malignancies Meeting by May 15th!!! This is a fantastic meeting for trainees!
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Excited to announce our annual New York City Edward P. Evans MDS Centers Symposium across @MSKCancerCenter & @Columbia on Monday, July 14, 2025. This year to be held at @MSKCancerCenter. See this flyer below and register here: https://t.co/uNeFLh0O2z
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Excited to share that @Doulatov_lab has moved to Columbia University Medical Center @ColumbiaPHY!! After wonderful 8 years at UW, we are excited to join this vibrant Columbia @columbiacancer and NYC scientific community.
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Check out our latest work by @MartinaSarchi in @BloodAdvances!
🎉 I’m happy to share our latest work on clonal progression of SF3B1-mutant MDS. Check it out @BloodAdvances! 🩸 Thanks to @Doulatov_lab, Malcovati group @unipv, all co-authors and @AIRC_it for the support. https://t.co/2BhuNpfTdG
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Thanks to the generous support of @EHA_Hematology we have two travel awards for early career researchers working in Europe to attend the 2025 FASEB Hematologic Malignancies Meeting!!! Please share! (Link in comments)
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In preprints: insights into the regulation of haematopoietic stem cell emergence in vitro and in vivo George Hunt & Ana Cvejic discuss a recent #preprint @Doulatov_lab: https://t.co/V6qcZ50BNQ
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