Laurent Gapin
@GapinLaurent
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Professor - Immunology - University of Colorado
Joined June 2020
Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models
cell.com
Our study presents a comprehensive atlas of human innate T (Tinn) cells in the thymus and blood, highlighting their blended type 1 and type 17 transcriptional profiles. Loh et al. use single-cell RNA...
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Happy to share new work from us on persisting impairment of #MAIT cells in people recovering after very severe #COVID19. These results suggest weakened antimicrobial #immunity in this patient group. https://t.co/z7zn56JNyb
@karolinskainst @CIM_Sweden @J_Immunol
academic.oup.com
The JI publishes peer-reviewed manuscripts describing novel findings in all areas of experimental immunology, including both basic and clinical studies.
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In collaboration with the Meyer lab (@HannahVMeyer ), latest work by Dr. Loh and Salome Carcy (@CarcySalome ) where we analyzed using single cell RNA-seq the transcriptional states of innate-like T cells (NKT, MAIT and GD) and conventional T cells in the human thymus and blood.
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Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models https://t.co/kJ0bYHBKbl
#biorxiv_immuno
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In collaboration with the Meyer lab (@HannahVMeyer ), latest work by Dr. Loh and Salome Carcy (@CarcySalome ) where we analyzed using single cell RNA-seq the transcriptional states of innate-like T cells (NKT, MAIT and GD) and conventional T cells in the human thymus and blood.
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New work from the lab by Dr. Loh about the role of MAIT cells in a spontaneous model of colitis using the Collaborative Cross mice https://t.co/8MBRohyf2H
biorxiv.org
Background & aims Lymphocytes that produce IL-17 can confer protective immunity during infections by pathogens, yet their involvement in inflammatory diseases is a subject of debate. Although these...
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Lipids regulate peripheral serotonin release via gut CD1d
cell.com
Enterochromaffin (EC) cells are known as the major source of gut-derived serotonin (5-HT). Luo et al. demonstrate that lipid-mediated engagement of invariant natural killer T (iNKT) cells with EC...
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Following adjuvanted vaccine administration, effector and memory T cell formation is compromised in the absence of T-bet or FOXO1 @KedlRoss @CellReports
cell.com
In T cells responding to infection, T-bet directs the formation of effector cells but not memory, while FOXO1 directs that of memory but not effectors. However, Ivanova et al. show that following...
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Chancellor, Simmons, De Libero @UniBasel_en, Lepore et al. show that promiscuous recognition of MR1 by canonical MAIT TCRs endowed w/ dual reactivity to both microbial and self-antigens enables MAIT cell responses in the absence of microbial infection. https://t.co/C2weYKfpRc
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What's the best bioinformatics book that you recommend to read for beginners? I will start 🧵 👇
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Promiscuous recognition of MR1 by canonical MAIT TCRs endowed with dual reactivity to both microbial and self-antigens enables MAIT cell responses in the absence of microbial infection @JExpMed
https://t.co/ntPxrexfL5
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Professor Yasmine Belkaid was appointed President of the Institut Pasteur by its Board of Governors for a six-year term. She will take office in January 2024. ↘️
pasteur.fr
On March 29, 2023, Professor Yasmine Belkaid was appointed President of the Institut Pasteur by its Board of Governors for a six-year term. She will take office in January 2024.
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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages
cell.com
To dissect the contribution of antigen receptor specificity during γδ T cell development and function, Hahn et al. generate a mouse model with a monoclonal TCRδ chain that highlights the inter-depe...
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Selective engagement of Vγ9Vδ2-T and type 1 NKT cells using a CD1d-Vδ2 Bispecific T cell engagers results in robust antitumor activity and is well tolerated in NHPs @CellRepMed
https://t.co/BKkDVkRSk9
cell.com
Bispecific T cell engagers (bsTCEs) show anticancer therapeutic activity but face challenges due to toxicity and regulatory T cell engagement, limiting efficacy. Lameris et al. demonstrate that...
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So excited and honored to be part of this group! Thanks to past and current lab members-love you! And to @Typhi @victornizet @DMAronoff for nominating me! Representing CO w @Horswill_Lab 🏔️@CUAMCImmu_micro
asm.org
The American Academy of Microbiology elected 65 new Fellows to the Class of 2023. Fellows are elected annually based on their records of scientific achievement and original contributions that have...
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We are looking for a PhD candidate to explore MAIT cell development using new tools🐁. Starting date: next Fall ! More information and applications 👇
Among the projects of the 2023 IGDR PhD program: Real-time analysis of the development of microbe-specific T lymphocytes called MAIT cells, in the new team headed by François Legoux, https://t.co/gBcfGEQUvT
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Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern
frontiersin.org
Most current anti-viral vaccines elicit a humoral and cellular immune response via the pathway of phagocytic cell mediated viral antigen presentation to B an...
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