Happy to share our latest findings out today in @PNASNews by @C_Boulouis showing how human mucosal-associated invariant T (#MAIT) cells rapidly adapt their functional response profile to cues in the microenvironment @karolinskainst @CIM_Sweden #immunology.

Today Tobias Kammann @TobiasKmmnn did the traditional "nailing" of his PhD thesis at the @karolinskainst library. This tradition goes back many years and marks the publication of the thesis, nowadays complemented with an "e-nailing" of the thesis pdf at the library website 🥂👍

RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….

RT @SciImmunology: A new study in Science #Immunology details the tissue-adapted roles of human mucosal-associated invariant T (#MAIT) cell….

Thank you for highlighting our work!.

This was a tremendous effort by all IHOPE consortium members, including most notably @tobiasKmmnn @emouchtaridi as well as many members of @marcus_buggert @MjosbergL @jakmic2003 @NicoleMarquard9 and @ELeeansyah labs.

In summary, these findings provide a spatial dimension to our understanding of human MAIT cells and a roadmap to investigate tissue-dependent adaptations in this conserved part of host immune defense.

Both intestinal and hepatic adaptations accumulated with donor age. In contrast, the previously observed decline in circulating MAIT cell numbers in blood with age was not evident in the tissues, indicating that the tissue resident MAIT cell compartment does not decline with age.

We go into detail to show that the CD56+ MAIT cell subset has limited TCR repertoire breadth, elevated MR1 binding, and a transcriptional profile skewed towards innate activation pathways. Transition to this functional phenotype can be driven by exposure to antigen or IL-7.

We study paired-tissue specimens to show that MAIT cells develop distinct functional specializations depending on their tissue localization. Notably, intestinal MAITs have a CD39+ barrier protective function, whereas hepatic MAITs have a CD56+ enhanced effector function profile.

Happy to share our latest findings out today in @SciImmunology on tissue site adaptation of resident human mucosal-associated invariant T (#MAIT) cells @karolinskainst @CIM_Sweden #immunology.

RT @ELeeansyah: Extremely proud to share this latest work from my lab @TsinghuaSIGS in @ScienceAdvances on understanding #MAIT cell recruit….

Exciting science at the #AAI2024

RT @J_Immunol: AAI is thrilled to announce a new partnership with Oxford University Press! @OUPAcademic will begin publishing The JI & @Imm….

RT @J_Immunol: Authors who mistakenly submit to a predatory publisher may have to pay fees not transparently communicated. Also, articles m….

RT @Israel: Entire families obliterated for one reason: they were Jewish. Today on International Holocaust Remembrance Day, we commemorat….

RT @astro_marcus: Ready for launch. I am immensely grateful and impressed by everyone who made this mission possible. A special thanks to….

RT @infdisease_news: 🔬 Dr. Johan Sandberg (@SandbergLabKI) and @karolinskainst researchers investigated the capacity of mucosal-associated….

Happy to share new work from us on persisting impairment of #MAIT cells in people recovering after very severe #COVID19. These results suggest weakened antimicrobial #immunity in this patient group. @karolinskainst @CIM_Sweden @J_Immunol.

RT @marcus_buggert: Check out our new study in @SciImmunology. Despite signs like increased PD-1 expression on spike-specific CD8+ T cells,….