Fadi Najm
@FadiNajm
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Cancer biologist, genome engineer, uncle, fitness enthusiast
Cambridge, MA
Joined January 2014
More from less - target over 13,000 genomic sites with 24 guides! Excited to share our new paper on bioRxiv on multi-locus CRISPRi. Thanks to all co-authors! #BroadInstitute #GRO #CRISPR
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It’s out! Check out our latest published work extending the application of CRISPRi by multi-targeting. Huge thanks & congrats to co-leads Molly Moore & Siddarth Wekhande & our collaborators! Stay tuned, this is just the beginning. #BroadInstitute.
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Big CONGRATS to Alejandro Collins in the lab who will join the PhD program at @UCBerkeley in the Fall! We’ll certainly miss you @GRO_Broad @broadinstitute.
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Guess what?! The @JD_Buenrostro and @FadiNajm labs got a Broad SPARC award! Incredibly grateful for this opportunity. Thanks to the Broad SPARC committee and benefactors who empower us to push the limits and dream big @broadinstitute @GRO_Broad.
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Also sharing a tweetorial poem we composed during lab meeting: .A truncated guide can target hundreds of loci. We disrupt TF sites in numbers that are high,.Unprecedented scale of functional screening,.Gives CRISPRi screens a whole new meaning!.
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RT @BradEBernstein: Honored to be included among this remarkable group. Many thanks to the NAM! And many thanks to the brilliant colleagues….
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Huge congratulations to our GRO co-Director, collaborator, and all-around awesome person @JD_Buenrostro on winning the “Genius Grant”. Super well-deserved!.
I’m so honored and grateful to be named a MacArthur Fellow! I’ve been absolutely flooded with texts, emails and likes. What a wonderful experience to hear from colleagues, collaborators, friends, and family. Thank you all for the support and encouragement!
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RT @JSheltzer: Check out our new study in @ScienceMagazine, where we take on a 100-year-old debate: what’s the role of aneuploidy in cancer….
science.org
Specific aneuploidies benefit cancer cells and may be sensitive to treatment
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RT @vangalenlab: Super proud and thrilled that this paper is out! 📃 Many thanks to the fantastic team - I’ll fondly remember the lengthy di….
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RT @ZeyuCHEN19: Excited to share our latest work dissecting a CD69 enhancer at base resolution out in @cellgenomics today .
cell.com
Chen and Javed et al. integrated epigenetic perturbations, base editing, and deep learning to dissect a CD69 enhancer. They identified a single C-to-T mutation that impacts gene expression by...
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Big congratulations to Molly Moore in lab on securing an NSF Graduate Research Fellowship! Molly joined the lab 2 years ago & was a superstar from the beginning. I can't wait to see the cool things she'll do in graduate school & beyond. The future of chromatin science is bright!.
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Thankful and honored to be recognized as a BroadIgnite researcher! The award will be put to good use identifying cancer targets. Many thanks to Molly and Alejandro on the team and donors!.Find out more:.#broadinstitute #broadignite.
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RT @brian_b_liau: Want to find functional sites in protein complexes? Or design chemical probes/tools to study biological mechanisms? And b….
liaulab.com
Contact
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RT @GRO_Broad: Thank you to the GRO community for a fantastic day of scientific discussion @broadinstitute yesterday for our 2nd Annual GRO….
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Our paper on combinatorial screening in leukemia is out in @NatureComms Thanks to an incredible team! @broadinstitute @DanaFarber @BradEBernstein
nature.com
Nature Communications - Epigenetic regulators are potential therapeutic drug targets in leukemia. Here, the authors perform combinatorial CRISPR knockouts to test gene-gene pairings in leukemia...
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Congrats @BoXia7!.
Our C.Origami work is online @NatureBiotech! A tour de force by @tan_jimin and a wonderful collaboration with @artsinyc. Check out how we use high-throughput in silico genetic screen to discover new regulation of genome organization. Full manuscript here:
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RT @ZeyuCHEN19: Really excited to share our new strategy combining deep learning predictions, epigenetic profiling, genetic perturbation to….
biorxiv.org
Although vast numbers of putative gene regulatory elements have been cataloged, the sequence motifs and individual bases that underlie their functions remain largely unknown. Here we combine deep...
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RT @Sofi_Battaglia: I am extremely enthusiastic to share our work published today in @NatureGenet. We establish a targeted @nanopore sequen….
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Hey @KINDSnacks is this granola I just bought online expired? “Best by 28 MAR 20” 🤔 We run into this a lot in the lab, more digits please!
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