Gene Regulation Observatory
@GRO_Broad
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The GRO of the Broad Institute brings together a community to investigate the regulation of context-specific gene expression within cells.
Broad Institute, Cambridge MA
Joined January 2021
Fantastic work by GRO researchers @jmartinrufino Alexis Caulier and @bloodgenes to enable systematic mapping of genetic variation impacting hematopoiesis.
I am thrilled to share my preprint with #AlexisCaulier and others in @bloodgenes lab, showing how systematic mapping of transcription factor networks in human hematopoiesis massively enriches for heritability of blood cell phenotypes! A thread below (1/n)
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RT @Anders_S_Hansen: (1/2) New paper from KL Kim @GilbertRahme @BradEBernstein @GRO_Broad with RCMC contribution from @ViraatGoel @hansen_l….
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Denmark's healthcare system has a unique ability to expand the 'Frontiers of Implemented Genomic Medicine'-learn about this in an upcoming Symposium hosted by @kasper_lage & Maria Rossing, Rigshospitalet. Speakers include Danish & @broadinstitute leaders
broadinstitute.swoogo.com
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This week we held our Third Annual GRO Retreat @broadinstitute and it was a blast! Thank you to our keynote speaker Benjamin Ebert, our visiting speaker @sara_mostafavi & all of our contributing discussion leaders, breakout participants, poster presenters. An incredible group!
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RT @FadiNajm: Guess what?! The @JD_Buenrostro and @FadiNajm labs got a Broad SPARC award! Incredibly grateful for this opportunity. Thanks….
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RT @FadiNajm: More from less - target over 13,000 genomic sites with 24 guides! Excited to share our new paper on bioRxiv on multi-locus CR….
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RT @BradEBernstein: Honored to be included among this remarkable group. Many thanks to the NAM! And many thanks to the brilliant colleagues….
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RT @Anders_S_Hansen: Come and join us!.We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024.….
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Continuing an exciting week for the GRO community here @broadinstitute. Congratulations to our Director @BradEBernstein on his election to the @theNAMedicine!.
Honored to be included among this remarkable group. Many thanks to the NAM! And many thanks to the brilliant colleagues and trainees I’ve had the privilege of working with over the years!.
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RT @BoXia7: Congratulations Jason @JD_Buenrostro !! A true genius, a humble person, and a wonderful mentor!.
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RT @HSCRB: Congratulations HSCRB Associate Professor @jd_buenrostro for being been named a 2023 #MacFellow! @macfound .
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Thanks @TreyIdeker for a fantastic talk yesterday, and to @CarolineUhler and the @Schmidt_Center for inviting us to cohost this event.
Thanks, @TreyIdeker, for packing the room yesterday w/ a great talk on "Building a mind for cancer!" .ICYMI: we'll share a recording of the talk soon.
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RT @nytimes: Twenty Americans, all anonymously nominated, were recognized on Wednesday by the MacArthur Foundation with $800,000 fellowship….
nytimes.com
On Wednesday, 20 Americans, all anonymously nominated, were recognized by the MacArthur Foundation with $800,000 fellowships often referred to as the “genius” award.
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Congratulations to our very own Co-Director @JD_Buenrostro, one of the new cohort of MacArthur fellows! @broadinstitute.
Jason Buenrostro (@JD_Buenrostro) is a cellular and molecular biologist and 2023 MacArthur Fellow investigating the mechanisms that regulate gene expression. #MacFellow. Explore his work and all the 2023 MacArthur Fellows on our website!.
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Congrats to team including @hovestadt @gryfyndor @vangalenlab @lane_andy for this @Nature publication exploring the development of acute leukemia type #BPDCN through genomic/single-cell analyses of patient samples across tissue sites.
excited to share our latest. wonderful collaboration with @gryfyndor @vangalenlab @lane_andy and many more. (open access). tweetorial below 👇.
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Thank you to the GRO community for a fantastic day of scientific discussion @broadinstitute yesterday for our 2nd Annual GRO Retreat! Inspiring talks from all levels of scientists & great conversation throughout. Photo by our own @labronic_mike
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Congratulations to @GRO_Broad Fellow @BoXia7 for his latest work, out now in @NatureBiotech. Collaborating with @artsinyc, the team developed C.Origami - a machine learning tool for predicting chromatin organization!.
Our C.Origami work is online @NatureBiotech! A tour de force by @tan_jimin and a wonderful collaboration with @artsinyc. Check out how we use high-throughput in silico genetic screen to discover new regulation of genome organization. Full manuscript here:
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In preprint now, check out another exciting project from GRO collaborators including @FadiNajm @lucapinello @BradEBernstein @ZeyuCHEN19 towards the goal of understanding regulatory elements at base resolution
biorxiv.org
Although vast numbers of putative gene regulatory elements have been cataloged, the sequence motifs and individual bases that underlie their functions remain largely unknown. Here we combine epigen...
Really excited to share our new strategy combining deep learning predictions, epigenetic profiling, genetic perturbation to dissect gene regulatory elements at base resolution, and find transcriptional fulcrum in regulating immune response~
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Out now in @NatureGenet, led by @Sofi_Battaglia with GRO’s @FadiNajm, Shoresh, and @BradEBernstein labs! Check out our strategy for phasing gene regulatory landscapes & its elucidating results.
I am extremely enthusiastic to share our work published today in @NatureGenet. We establish a targeted @nanopore sequencing approach for ultralong-read epigenomic profiling and discover a novel, primate-specific enhancer driving bi-allelic IGF2 expression.
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RT @s_mangiameli: Sharing Photoselective Sequencing (PSS), a new method for genomic and epigenomic measurements within spatial regions of i….
biorxiv.org
In biological systems, spatial organization is interconnected with genome function and regulation. However, methods that couple high-throughput genomic and epigenomic profiling with spatial informa...
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