Using single-cell genomics and advanced network analysis, Gupta et al. mapped gene networks in key brain cell types across schizophrenia, bipolar disorder, and autism. This innovative approach...

Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcrip...

Piron et al. present the tool colocRedRibbon, which identifies hundreds of gene regions where genetic variation influences diabetes risk and glycemic traits through effects on pancreatic islet gene...

Dolsten et al. map the 3D chromatin architecture across early Drosophila development using high-resolution Micro-C, and, by integrative analysis with 149 public ChIP-seq datasets, identify four...

LaFlam et al. combine deep mutational scanning, structural biology, and machine learning to characterize how missense variants affect the expression and function of the immune GPCR P2RY8. Their...

Traditional models of epigenetic memory support binary memory. Targeted editing of the chromatin state, coupled with temporal tracking of gene expression with clonal resolution, reveals that epigen...

Lin et al. developed a high-throughput cell surface peptide display platform and coupled it with a β-arrestin-based melanocortin-4 receptor reporter to rapidly screen over 2,000 β-melanocyte-stimul...

Mu et al. performed single-cell chromatin accessibility quantitative trait locus (caQTL) mapping in human peripheral blood mononuclear cells and found that caQTL explain roughly 50% more disease...

Qi et al. developed a statistical method for transcriptome-wide association studies (TWASs) using single-cell eQTL data. By capturing continuous cell states, the method improves power and provides...

Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the...

Identifying key enhancers underlying disease susceptibility is a significant challenge. By mapping chromatin contacts between enhancers and promoters across five pancreatic cell types, Wang et al....

Yang et al. determined the structures of F. rodentium Cas9 ternary complexes in two conformational states, revealing the distinctive structural features of the sgRNA-DNA heteroduplex. Through in...

Single-cell RNA sequencing revealed significant arterial segment heterogeneity within human subjects, primarily in smooth muscle cells and fibroblasts. Differential gene expression (protein-coding...

Navratilova et al. profiled several epigenetic features across three stages of barley embryo and leaves and predicted regulatory potential for 1.4% of the barley genome. Using HiChIP, they linked...

Pak, Saurty-Seerunghen et al. present a method, GoT-Multi, that co-detects single-cell multiplexed somatic genotyping and whole transcriptomes in high throughput from fresh or FFPE samples, overcom...

Pallares et al. collect over a thousand RNA-seq and DNA samples from Drosophila melanogaster flies to investigate the genetic basis of gene expression variation. They find eQTLs for 98% of the genes...

Transposable elements can drive genetic innovation. In this issue of Cell Genomics, Adami et al. investigate the impact of hominoid-specific L1 retrotransposons on early embryonic and brain develop...

The Galaxy single-cell and spatial omics community (SPOC) brings together over 175 tools, 120+ training resources, and a global user community in a unified FAIR platform. By integrating leading...

Vučićević et al. describe TESLA-seq, which combines pooled CRISPR activation with targeted single-cell RNA-seq to map enhancer-gene connections at high sensitivity. TESLA-seq was applied across a...

Esophageal adenocarcinoma (EAC) often progresses from Barrett’s esophagus (BE), a complication of gastroesophageal reflux disease. Wenzel et al. studied cells from EAC and BE tissues and found a set...