Luca Braccioli
@LucaBraccioli
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Assistant Professor at UU | Epigenomics | In vitro embryo models Follow us on Bluesky - @bracciolilab.bsky.social
Amsterdam
Joined January 2020
RT @KStapornwongkul: Thrilled to announce that we are looking for a Research Technician/Assistant to join our lab @IMBA. Please consider ap….
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RT @Dev_Cell: Online now: Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids .
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9/10 This framework lays the foundation of my recently established lab @UUBeta where we will investigate the interplay between gene regulation and inter-tissue communication!.
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8/10 In conclusion, our work provides an innovative framework for dissecting the crosstalk between gene regulation and inter-tissue communication in mammalian embryonic development.
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7/10 Finally, we used chimeric gastruloids derived from a mix of wild-type (WT) and MSGN1 KO cells. This revealed that MSGN1 KO cells can form spinal cord in the presence of WT cells. This indicates an underlying inter-tissue communication program driven by MSGN1.
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6/10 Surprisingly, MSGN1 KO not only impaired mesoderm development, as anticipated, but also negatively affected spinal cord development. This reveals an inter-tissue role of MSGN1 that was previously unknown.
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5/10 We were particularly struck by MSGN1 and CDX2 as potential drivers of the early decision from neuromesodermal progenitors (NMPs) to mesoderm and spinal cord, respectively.
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4/10 Next, we investigated which transcription factors (TFs) are active during gastruloid development. To do this, we defined the developmental trajectories in gastruloids and predicted TF activity based on their motif accessibility.
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3/10 We discovered that the chromatin regulatory profile of gastruloids strikingly matches that of post-gastrulation embryos.
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2/10 We utilized single-cell ATAC-seq to analyze developing mouse gastruloids, successfully defining their chromatin regulatory profile.
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1/10 Our research aimed to answer two key questions: how do pluripotent cells make early cell fate decisions? and how does gene regulation drive these decisions?.
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Very interesting work from the Moris lab advancing our understanding in inter-tissue communication during human trunk development!.
Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)
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RT @nmoris: Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscl….
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Great work from the Martinez Arias lab on the morphogenetic constraints in gastruloid development!.
A study on #morphogenetic constrains in the development of #gastruloids and its implications for mouse gastrulation Effect of initial size on gene expression, polarization & elongation.@AMA_Lab led by Ulla Fiuza #IInNumbersWeTrust #NotInTheGenes
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RT @tinekelenstra: Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technolo….
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RT @EMBLEvents: Welcome to 'Quantitative biology to molecular mechanisms' 🧬🙌🏻 Hope everyone is enjoying day 1️⃣ of the conference! #EMBLOmi….
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📢 We are very excited to announce the first International Dutch Embryo Model Meeting in Nijmegen on March 27-28. See below for details. Don't miss this fantastic opportunity to connect with the embryo model community!.
📢 Save the date! I am excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday 27 March and Friday 28 March! Registration is open now, or more information: Direct link to registration
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RT @hendrik_marks: 📢 Save the date! I am excited to announce the International Dutch Embryo Model Meeting 2025 in Nijmegen (NL) on Thursday….
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