Fiona Serack, PhD
@FionaSerack
Followers
103
Following
1K
Media
7
Statuses
48
Research Scientist @BroadInstitute | Outdoor Enthusiast | UWO & Queen'sU alumni | She/Her 🔬⛰️🧗
Cambridge, MA
Joined November 2018
Today we introduce a new drug candidate for prion disease: a PrP-lowering divalent siRNA. A 4-year collaboration with @RTI_UMassChan enabled by @NINDSfunding IGNITE & URGenT mechanisms. https://t.co/Z10daPZGEw Our hope is to advance this to the clinic, wish us luck!
6
26
169
Scientists at @WhiteheadInst and Broad have developed a gene-silencing tool to potentially treat fatal prion diseases by turning off the disease-causing gene. A promising step towards gene therapy for diseases that lack treatments. https://t.co/XcAKv6YPz7
0
24
70
We believe this will forge a path to a much-needed prion disease treatment, and we think CHARM could potentially be applied to other neurodegenerative diseases. Please also check out this excellent perspective piece by @mn_whittaker and @kiranmusunuru! https://t.co/SpzJ8PdWQf
science.org
A new class of editor has improved delivery, durability, tunability, and safety
1
7
37
Working with @FionaSerack & co. in the lab of prion experts Sonia Vallabh and Eric Minikel @cureffi, along with AAV expert Ben Deverman @DevermanLab & co., we demonstrate that CHARM can potently repress the prion protein throughout the mouse brain.
1
2
10
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
https://t.co/DrV4EGe92z
16
75
502
Honored to be a part of this collaboration and work with such an incredible team! Check out the fantastic CHARM paper led by @EdwinNNeumann and @TessaBertozzi, as well as Eric’s awesome break down both here and on the @cureffi blog!
Introducing CHARM: a new epigenome editor to methylate DNA at the promoter of a targeted gene. Our lab's collaboration with @JswLab's @EdwinNNeumann & @TessaBertozzi shows deep silencing of brain PrP Paper: https://t.co/HZRKk2m1b2 Blog: https://t.co/crVVYpyI6w
1
1
5
#CBS2022 day 2! Come see the @FlynnRegenLab presentations - I'll be presenting in the morning session of cardiovascular materials, and @JuliaTerek will be presenting this afternoon in neural materials! Hope to see you there 🤩
0
2
12
All ready to start day 3 of @CanBiomatSoc conference! Come hear about my research in the Stem Cells & Regeneration Session at 2pm! @JuliaTerek will be on at 2:30! 🦠👩🔬🔬 #FlynnLab
0
0
3
Looking forward to spending the next couple days catching up with colleagues and learning about all the fascinating biomaterials research happening in Canada at the annual @CanBiomatSoc meeting! 👩🔬🇨🇦☕😁
1
1
6
Spending my morning learning and talking about stem cells and their exciting applications with hopefully some future stem cell scientists and bioengineers!! 👩🔬👨🔬🔬✨#SCT2021 @LondonSct @LetsTalkScience
Our volunteers are gearing up for StemCellTalks 2021 🧫 grab your ☕️ and get ready for some super cool science! #SCT2021 @LetsTalkScience @StemCellNetwork
0
1
6
Western, you're well represented! Fantastic keynote from @annakornmuller and presentations from @FionaSerack and Julia during our Regenerative Medicine Session. Looks like they had as much fun presenting as we did listening! #CBSSWOSC_Symposium
0
4
8
Today, we remember the 14 women who were murdered in Montreal 31 years ago, and hold in our thoughts all women who experience violence. Let that grief fuel us to work harder to make the world safe and just for all.
0
78
291
Super excited for this morning's patient presentation at #TMM2020 ! Featuring @joshua_dierolf ...what more could you ask for?! @StemCellNetwork
0
0
7
Really great advice coming from @Professeltine @nika_shakiba and Florian Bentzinger during the Early Career Investigators Panel hosted by @AmyWongphd at #TMM2020 ! Awesome session!
0
0
8
We're saddened by the passing of celebrated #HiddenFigures mathematician Katherine Johnson. Today, we celebrate her 101 years of life and honor her legacy of excellence that broke down racial and social barriers: https://t.co/Tl3tsHAfYB
1K
51K
127K
Attention @westernuBJI trainees! Mark your calendars for our first Lunch & Learn of the year. A great chance for us to share research, practice presentations and get feedback. PS, there will be FREE PIZZA. Sorry PIs, this is a trainee only event - you're not allowed to come!
0
8
11
Talking about regenerative medicine, research, and then fun of grad school with @thejahcoop @Flash_Gordon96 at the 1st @carrm_western symposium! @CARRMofficial 👩🔬👨🔬👨🔬🔬💜
0
2
4
It's not too late to plan a visit to the @children_museum today #LdnOnt! We'll be hosting a fun workshop for children from 11am-2pm. Come learn how #bones & #joints help you move & play! You can even play with some real research tools like microscopes & implants! #STEMeducation
0
4
8