ShengWang
@DR_WANG_SIBCB
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Psilocybin on sober mice? That's like asking a teetotaler to review a fine wine. The absence of replicable persistent effects in healthy mice doesn't negate potential therapeutic value in relevant disease models.
A multi-institutional investigation of psilocybin's effects on mouse behavior
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Cool finding for #psychedelic @Nature .A specific brain circuit and 5-HT2A receptor have been found to be required for psilocybin’s long-term effects on neural plasticity and depression-related behaviour. .
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁. Led by Ling-Xiao Shao and @ItsClaraLiao . Funded by @NIH @NIMHgov . 📄Read in @Nature - 1/12.
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Wow: Sodium pocket for partial agonist design. It seems the right place for different GPCR. Opioid receptor👇 and CB1:
Glad to share a great teamwork with @sushmajumdarlab @sevakat1, Jay McLaughlin lab, and @AmynahPradhan @Cannabatopia. This bitopic approach pioneered by Drs. Majumdar and Katritch works pretty well in GPCRs. Thanks to the support from @NIDAnews and WashU.
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Nice peripherally DREADD!! Congrats to the .@RothLabUNC team (especially @gori7873.and Brian Krumm) and Greg Scherrer's lab,.
Congrats to the team: especially @gori7873 and Brian Krumm from @RothLabUNC and Adrien and Matan from Greg Scherrer's lab!!.A ton of work!.Structure-guided design of a peripherally restricted chemogenetic system: Cell
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RT @NatRevNeurosci: Structural neural plasticity evoked by rapid-acting antidepressant interventions — a Review by Clara Liao, Alisha Dua,….
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Seems it correlation with Today published Science paper!@kwanalexc.
Our latest study - psilocybin evokes structural neural plasticity, and we wanted to know how this maps onto pyramidal cell type-specific circuits to produce behavioral effects. 🍄🔬🧠. Link to @biorxivpreprint: Led by Ling-Xiao Shao and @ItsClaraLiao.
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RT @tinakim_neuro: Happy to share the lab’s latest research tagging psychedelic-activated neurons in mice. See the post below from first au….
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Interesting story：the anti-anxiety and HTR effect of DOI rely on different neural circuitry.
Check out our latest collaboration in @ScienceMagazine Magazine with @tinakim_neuro's lab, where we re-activate psychedelic-responsive neurons to induce an anxiolytic effect without a head-twitch response.
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LSD primarily activates serotonin and dopamine receptors in the brain. The differing kinetics of its receptor binding cause changes in hallucinogenic experiences over time. Understanding these binding mechanisms will guide future drug design. Free link:.
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Nice perspective from @RothLabUNC on our recent FSCA paper. Bryan's perspective @ (FSCA for polypharmacological drug design @ ).
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RT @NaturePortfolio: A modified psychedelic found in the venom of a poisonous toad could be an effective treatment option for depression an….
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Wow，must try.
Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬. Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵
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RT @WackerLab: Tetracyclic Antidepressants Activate Understudied Serotonin Receptors: Congrats to @NeuroStruct, @Al….
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The new structures elucidates why bile acids are perceived as bitter-tasting compounds.😜.
Nature research paper: Bitter taste receptor activation by cholesterol and an intracellular tastant
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The Flexible Scaffold-based Cheminformatics Approach (FSCA) work @CellCellPress is a collaboration between our lab, @chengjj_iHuman, and Prof. Eric Xu at SIMM.
Drawing inspiration from Zhuangzi's "Free and Easy Wandering," where he vividly portrays the transformation of a fish Kun into a bird Peng, our proposed FSCA method, @CellCellPress, presents a groundbreaking concept in polypharmacological drug design.
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Drawing inspiration from Zhuangzi's "Free and Easy Wandering," where he vividly portrays the transformation of a fish Kun into a bird Peng, our proposed FSCA method, @CellCellPress, presents a groundbreaking concept in polypharmacological drug design.
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The 4th breakthough therapy for psychedelic. Psilocybin(x2), MDMA(x1).
LSD： FDA Breakthrough Therapy for Anxiety.
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