Tao
@TaoChelab
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Washington University in St. Louis; Structure and function of GPCRs
St Louis, MO
Joined November 2017
RT @sushmajumdarlab: A NOA from NIDA on a UG3 grant is here. Excited to work with Brian Kobilka and Jay Mclaughlin on NAMs for treating opi….
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RT @KLabGPCR: We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but t….
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Glad to share a great teamwork with @sushmajumdarlab @sevakat1, Jay McLaughlin lab, and @AmynahPradhan @Cannabatopia. This bitopic approach pioneered by Drs. Majumdar and Katritch works pretty well in GPCRs. Thanks to the support from @NIDAnews and WashU.
nature.com
Nature Communications - δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and...
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RT @sushmajumdarlab: A cannabinoid bitopic, biased and peripheral agonist analgesic with limited tolerance and tetrad in Nature. Work led b….
nature.com
Nature - A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance,...
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RT @sushmajumdarlab: In Nature collaborative work with Kobilka and McLaughlin labs on NAM's of MOR. @ClinicPharmSTL @WUSTLmed @WUSTL_AnesRs….
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RT @zenbrainest: Congrats to @KYoojoong @rgumpper @RothLabUNC . Bitter taste receptor activation by cholesterol and an intracellular tastan….
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My honor to receive this award. Thank you @ASPET, and thanks to the nominators and committees. @WUSTL_AnesRsrch @ClinicPharmSTL.
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RT @WackerLab: Asenapine as a potent TAAR1 agonist. Congrats @NeuroStructure.
nature.com
Nature Communications - hTA1 is a drug target for several neuropsychiatric disorders. Using cryo-EM and pharmacological assays, the authors illuminate hTA1’s similarity to neurotransmitter...
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RT @zenbrainest: Wow!!.congrats @arshukla and gang!.
science.org
Structures enable visualization of atypical modes of β-arrestin interaction with transmembrane receptors.
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Thanks Christian. Thanks for managing the giant paper. Great teamwork.
Cool… more GPCR drug disvovery! @TaoChelab two NatureComm articles in one day. well done.
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Thanks for visiting WashU, Ruth. Great meetings and talk.
@WUSTL_AnesRsrch @Stanford_MCP I had a fantastic time visiting @WUSTL_AnesRsrch yesterday including a lot of interesting science discussion. Thank you @TaoChelab for hosting me.
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RT @ElgendyBE: Congratulations @TaoChelab @sushmajumdarlab @LameesHegazy and all authors. Great piece of work.
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RT @peptide_drugs: Very happy to see this published: computer-assisted design of #cyclic #peptide-conjugates for the #kappa #opioid recepto….
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Glad to share our review on opioid receptors. This is something we think worthwhile to try in the future, hope they are useful. @zenbrainest . Molecular basis of opioid receptor signaling
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RT @zenbrainest: Best wishes to @RothLabUNC alum @hustzsc who is starting his lab at Peking University!!
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RT @zenbrainest: We have contacted @jacksonlab and will deposit our mice from this paper as soon as possible so they will be available to a….
biorxiv.org
Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety,...
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RT @RuiZhangWUSTL: We are thrilled to share our latest structures of doublet microtubule from sea urchin sperm and bovine sperm. This is a….
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RT @AmynahPradhan: This was so much fun! Thanks for coming out @ClinicPharmSTL and friends @Jutkiewicz_Lab @DrSusieLIngram1 @MPuthenveedu @….
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