Tao
@TaoChelab
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Washington University in St. Louis; Structure and function of GPCRs
St Louis, MO
Joined November 2017
A NOA from NIDA on a UG3 grant is here. Excited to work with Brian Kobilka and Jay Mclaughlin on NAMs for treating opioid overdose upto IND phase. Several postdoc positions in both chemistry/pharmacology available. @washumedicine @WashUClinPharm Please RT
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We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! https://t.co/OabhjeWV1q
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Glad to share a great teamwork with @sushmajumdarlab @sevakat1, Jay McLaughlin lab, and @AmynahPradhan @Cannabatopia. This bitopic approach pioneered by Drs. Majumdar and Katritch works pretty well in GPCRs. Thanks to the support from @NIDAnews and WashU https://t.co/iJV5IgIoMb
nature.com
Nature Communications - δ-Opioid receptors (δOR) are promising targets for pain management with reduced side effects. Here, the authors use a structure-based approach to design and...
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A cannabinoid bitopic, biased and peripheral agonist analgesic with limited tolerance and tetrad in Nature. Work led by @Vipin36590264 with @robgereau @DrorLab kaavya Krishna Kumar @WashUClinPharm @WashUanesthesia A short thread https://t.co/29xlZf9K2I
nature.com
Nature - A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance,...
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In Nature collaborative work with Kobilka and McLaughlin labs on NAM's of MOR. @ClinicPharmSTL @WUSTLmed @WUSTL_AnesRsrch A big shout out to @evan_s_obrien @Vipin36590264
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Congrats to @KYoojoong @rgumpper @RothLabUNC Bitter taste receptor activation by cholesterol and an intracellular tastant https://t.co/NgIl2rk01V
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My honor to receive this award. Thank you @ASPET, and thanks to the nominators and committees. @WUSTL_AnesRsrch @ClinicPharmSTL
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Thanks Christian. Thanks for managing the giant paper. Great teamwork
Cool… more GPCR drug disvovery! @TaoChelab two NatureComm articles in one day.. well done
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Thanks for visiting WashU, Ruth. Great meetings and talk.
@WUSTL_AnesRsrch @Stanford_MCP I had a fantastic time visiting @WUSTL_AnesRsrch yesterday including a lot of interesting science discussion. Thank you @TaoChelab for hosting me.
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Very happy to see this published: computer-assisted design of #cyclic #peptide-conjugates for the #kappa #opioid receptor! #GPCR #Rosetta #pain
https://t.co/UNVlxSIede
@EdinMuratspahic @UWproteindesign @TaoChelab @MedUni_Wien
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Very happy to see this published: computer-assisted design of #cyclic #peptide-conjugates for the #kappa #opioid receptor! #GPCR #Rosetta #pain
https://t.co/UNVlxSIede
@EdinMuratspahic @UWproteindesign @TaoChelab @MedUni_Wien
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Glad to share our review on opioid receptors. This is something we think worthwhile to try in the future, hope they are useful. @zenbrainest Molecular basis of opioid receptor signaling
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We have contacted @jacksonlab and will deposit our mice from this paper as soon as possible so they will be available to anyone who wishes to use them. Please RT https://t.co/0CY4g4WfNC
biorxiv.org
Psychedelic drugs like lysergic acid diethylamide (LSD) and psilocybin have emerged as potentially transformative therapeutics for many neuropsychiatric diseases, including depression, anxiety,...
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We are thrilled to share our latest structures of doublet microtubule from sea urchin sperm and bovine sperm. This is a wonderful collaboration with Tzviya Zeev-Ben-Mordehai @TzviyaZBM , Alan Brown @alanbrownhms, and Susan Dutcher @DutcherLab.
I am thrilled our results on sperm axonemal doublet #microtubules are now out in Cell. Outstanding work of Miguel Leung and amazing collaboration with @RuiZhangWUSTL and @alanbrownhms
https://t.co/mTZrE6kcCb
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Incoming graduate student desk, @Fisk1866 student Vida Storm Robertson highlights @Nature paper from Tao Che's lab @WUSTL Using cryo-EM, authors studied κ-opioid receptorto ligands & selectivity of 4 types of Gi/o-family proteins to KOR/ligand complexes. https://t.co/3jhL2y9yd0
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This was so much fun! Thanks for coming out @ClinicPharmSTL and friends @Jutkiewicz_Lab @DrSusieLIngram1 @MPuthenveedu @jordacular @sushmajumdarlab @TaoChelab @ElgendyBE @reamalhasani @JohnStreicher1 and more! @WUSTL_AnesRsrch @UHSPedu #ASPET2023
Wonderful to see so many friends and colleagues @ASPET! Thanks for joining us at our networking event! #ASPET2023
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