Amy Strom
@DNAmyStrom
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Chromatin and cancer and condensates Lab Head in Discovery Oncology at Genentech.
Montara, CA
Joined May 2017
It's such an honor to be recognized by the Blavatnik Foundation in this way! Thank you to @Princeton for nominating me, and all my scientific mentors, collaborators and peers who were essential in my scientific and personal progress to get here. https://t.co/KBamqiQ4vv
ANNOUNCING 📣 the 2024 Blavatnik Regional Awards Honorees 🏅@AVBroeck @WeingartenShira @arthurCantab @NicoleLake @DNAmyStrom @ChemColumbia @Columbia @FlatironInst @Yale @YaleMed @Princeton @RockefellerUniv @broadinstitute 👏👏👏 @nationalpostdoc #NPAW2024
https://t.co/1uHmTWoZRH
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Shout-out to coauthors @drjorine @brangwynnelab And big thank you to @ASCBiology !! See the other winners here https://t.co/vvupXA9Oqh
ascb.org
ASCB and its research journal, Molecular Biology of the Cell (MBoC), are proud to recognize the outstanding scientific achievements of early career researchers through the 2025 Paper of the Year...
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Chuffed to be recognized with an Early Career Award from MBoC for work on chromatin induced phase separation of BRD4. ✨ Give it a read!
molbiolcell.org
Nuclear compartments form via biomolecular phase separation, mediated through multivalent properties of biomolecules concentrated within condensates. Certain compartments are associated with specific...
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Excited about turning basic science into new therapeutic modalities? Want to work with brilliant and *friendly* colleagues? Hoping to be part of a public university that shapes California? Then come join us #MolecularTherapeutics @MTI_UCB @berkeleyMCB !!!
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online: https://t.co/AifKRI8fbl
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Condensates, computation and cancer 🔥🔥🔥 Congratulations, colleague
I’m thrilled to share our preprint that uses deep learning to interrogate structure-function relationships in condensates! https://t.co/izhFI1ANXa In here, we ask: can AI read condensate biology from pictures alone? Turns out yes... see what we discover below! 🤖🧬🖼️ (1/10)
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👏🏼👏🏼👏🏼 incredible work and themed art by @yoonj_k
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🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. https://t.co/KGTUAZqHyS
biorxiv.org
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their...
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Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior. Congratulations Jing! Happy to have contributed in a small way to this interesting work! https://t.co/OZHRknyFV4
nature.com
Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...
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Our new work @biorxivpreprint 🔗 https://t.co/rpWHc1Br9k BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via bromodomain-mediated crosslinking: physical control of #chromatin by #LLPS transcription condensates. @semeigazin @katsu_s_minami @MasaAShimazoe
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Cancelling grants that were already competitively won and awarded is the waste and abuse. https://t.co/LzHROkH7qY
nytimes.com
The N.I.H. has terminated hundreds of diversity grants awarded to young researchers, many of whom come from the very places that supported Trump.
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Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. https://t.co/SyfgJfAvFf
nature.com
Nature Chemistry - Pathological aggregation of repeat-expanded RNA is implicated in neurodegeneration. Now results demonstrate that biomolecular condensates can promote irreversible clustering of...
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Huge thanks to my family, mentors, and funders for making this path possible — and to Genentech for the leap of faith. Can’t wait to get started next month!
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I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology! I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.
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Our recent collaboration with Ben Schuster's lab to characterize "protein surfactants"!
Amphiphilic protein surfactants reduce the interfacial tension of biomolecular condensates https://t.co/uMGTWjIxjh
#biorxiv_biophys
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Our new review paper is out @ JMB! 🧬 @katsu_s_minami @semeigazin @a_mond_future discuss DNA accessibility in euchromatin and heterochromatin in living cells. 📘 Free access: https://t.co/xkcZUpARmG 🔗 Also, check our previous paper on nucleosome motion: https://t.co/VF4XGubD3B
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This work was funded by @TheMarkFdn @Princeton @eprinceton @omenndarlingbio and through multiple federal sources @nih @nsf @AFOSR Please write to your representatives in support of scientific funding.
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This work was a joint effort with Hongbo Zhao @hbozhao, with contributions from Jorine Eeftens, Mikko Haataja, Andrej Kosmrlj and Cliff Brangwynne @brangwynnelab
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The structure of condensates and chromatin are interdependent Surface tension and stiffness– not just binding affinity or location– shape genome structure. Elastocapillarity offers a physical basis for mesoscale nuclear morphology & implications for gene regulation and disease.
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Multiple types of condensates coexist within one nucleus, potentially interacting mechanically through modulating the chromatin network– We found wetting condensates bundle and stiffen chromatin, constraining the size of non-wetting condensates.
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We investigated determinants of wetting and chromatin stiffness in living cells. Stiffness arises from chromatin density, while wetting is controlled by the strength and extent of chromatin binding, with heterochromatic protein HP1alpha’s chromodomain providing strong wetting.
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Elegantly, the variety of morphologies seen in nuclei can be produced from varying just two parameters– condensate wetting and chromatin stiffness. Nonwetting condensates in flexible networks cavitate fibers; wetting condensates engulf them. Stiff networks inhibit growth.
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