Priya R. Banerjee
@BanerjeeLab_UB
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learning how macromolecular phase transitions program cellular functions. interested in single-molecule biophysics, disordered proteins and RNA.
Buffalo, NY
Joined February 2019
How do RNAs phase separate without proteins? 💧💧🩸🩸 We are excited to share this story with you (preprint) "RNAs undergo phase transitions with lower critical solution temperatures". https://t.co/D9h3JNNqjC A longer thread will follow soon. @gable_wadsworth @PappulabWashU
biorxiv.org
Co-phase separation of RNAs and RNA-binding proteins is thought to drive the biogenesis of ribonucleoprotein granules. RNAs can also undergo phase transitions in the absence of proteins. However, the...
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📢 Abstract deadline Nov 1! Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers. ~30% talks from abstracts! https://t.co/2WAfu2RY1l
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Excited to announce the 2026 FASEB Conference on Phase Transitions in Cellular Signaling & Disease! An exciting speaker lineup and >30% of talks will be chosen from submitted abstracts. https://t.co/C7jUMxavkm 📅 Jan 11–15, 2026; 📍 Melbourne, Florida 🌴
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Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. https://t.co/SyfgJfAvFf
nature.com
Nature Chemistry - Pathological aggregation of repeat-expanded RNA is implicated in neurodegeneration. Now results demonstrate that biomolecular condensates can promote irreversible clustering of...
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Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single nucleosomes are responsible for A and B compartments in cell nucleus.
"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 https://t.co/hNWY0rxsnk I’m deeply grateful to my PhD advisor @taekjip and our incredible collaborators @MuirLab , @binzmit , Erika Pearce, and Ben Garcia lab!!
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DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation: Cell
cell.com
DNA binding and phosphorylation protect FOXP2, a transcription factor with the longest polyQ track in the proteome, from aggregation during interphase and mitosis. Harnessing these native solubilit...
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📢Excited to share our new paper in @NaturePhysics : Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor! How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity
https://t.co/qtt3HTDjVx?
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Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB
https://t.co/7z2JI83D4l 🧵1/3
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Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation https://t.co/nQEKwdrCwt
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This observation led us to investigate the impact of sugar modifications on RNA condensation. We found that 2'-O-methylation (2'-O-Me) negatively regulates RNA condensation and promotes reversibility, suggesting that 2'-O-Me serves as a tunable switch for RNA condensation. 2/2
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New preprint in collaboration with @jerelleaj!! We show that the 2’-OH group of ribose sugar plays a crucial role in RNA condensation, while its absence in DNA inhibits phase separation and percolation, a transition linked to condensate arrest. 1/2 https://t.co/naRSsl0I6f
biorxiv.org
Mg2+ ion-dependent RNA liquid–liquid phase separation with lower critical solution temperatures is driven by the phosphate backbone and modulated by the solvation property of nucleobases. Here, we...
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Excited to see this (cover) article on condensates come out in Scientific American. Nice quotes from me and many folks in the field. https://t.co/mJQICfc8Z4
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In collaboration with @BanerjeeLab_UB, we dive a little deeper into the microscopic interactions and sequence patterns shaping condensate activation energies https://t.co/A2nBb7TZzh. For more context, see also our prior work https://t.co/tba15pwksw
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Meet the CALVADOS RNA model on bioRxiv or on 🦋
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“I still believe that finding mind lodged in biological matter is the most profound question that physics can pose. And that the breadth of physics is a good base from which to begin.” This is what we believe too at @PRX_Life
This award is very hard to respond to. I have received many hundred congratulatory notes, from former students, post-docs, Princeton University juniors and seniors, funding agencies and foundations, authors, signature collectors, amateurs, elementary school neural network
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📢New paper alert!! With @boothbylab @alexholehouse @fried_lab we take a look at how an entire proteome survives desiccation. TLDR: Desiccation tolerance is encoded in specific residues on the protein surface, and occurs primarily in biosynthetic enzymes. https://t.co/v8OVBs1aFP
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RNA-driven phase transitions in biomolecular condensates. In this review or our #RNA focus issue, @BanerjeeLab_UB and colleagues take an RNA centric view of understanding ribonucleoprotein condensates.
cell.com
Ribonucleoprotein granules are thought to form via phase separation of RNA and associated proteins. Wadsworth et al. discuss the distinctive ways in which RNA critically contributes to the formation,...
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Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating the lifecycle of RNA, the regulatory roles of RNA, the importance of RNA in disease, and the technologies used to study RNA. https://t.co/Y4hNLNC5zz
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Our review on RNA-driven phase transitions is up today at Molecular Cell! Check it out! @BanerjeeLab_UB
cell.com
Ribonucleoprotein granules are thought to form via phase separation of RNA and associated proteins. Wadsworth et al. discuss the distinctive ways in which RNA critically contributes to the formation,...
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How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our lab & @LafontaineLab + Klinge. Genomics, engineered nucleoli, & modeling RNA-controlled nucleolar architecture!! (Tweetorial soon!) https://t.co/0Vo3GbwDWL
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