Priya R. Banerjee
@BanerjeeLab_UB
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learning how macromolecular phase transitions program cellular functions. interested in single-molecule biophysics, disordered proteins and RNA.
Buffalo, NY
Joined February 2019
How do RNAs phase separate without proteins? 💧💧🩸🩸.We are excited to share this story with you (preprint) "RNAs undergo phase transitions with lower critical solution temperatures". A longer thread will follow soon. @gable_wadsworth @PappulabWashU.
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Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates.
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RT @taekjip: Check out this tour de force study by Sangwoo Park and his incredible team of collaborators. Biophysical properties of single….
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RT @ShorterLab: DNA binding and mitotic phosphorylation protect polyglutamine proteins from assembly formation: Cell
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RT @sshekhr: 📢Excited to share our new paper in @NaturePhysics : Cooperative hydrodynamics accompany multicellular-like colonial organizati….
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Happy to share our new preprint on small molecule mediated inhibition of aging of biomolecular condensates.
In our new preprint, we study the physical aging of biochemically active condensates formed by an engineered Tau protein into disease-linked amyloid fibrils — and investigate whether small molecules can counteract this transition. @BanerjeeLab_UB .🧵1/3
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RT @Pha_Tran_Papers: Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation.
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This observation led us to investigate the impact of sugar modifications on RNA condensation. We found that 2'-O-methylation (2'-O-Me) negatively regulates RNA condensation and promotes reversibility, suggesting that 2'-O-Me serves as a tunable switch for RNA condensation. 2/2.
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New preprint in collaboration with @jerelleaj!! We show that the 2’-OH group of ribose sugar plays a crucial role in RNA condensation, while its absence in DNA inhibits phase separation and percolation, a transition linked to condensate arrest. 1/2.
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RT @brangwynnelab: Excited to see this (cover) article on condensates come out in Scientific American. Nice quotes from me and many folks i….
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RT @potoyangroup: In collaboration with @BanerjeeLab_UB, we dive a little deeper into the microscopic interactions and sequence patterns sh….
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RT @sesamedusa: “I still believe that finding mind lodged in biological matter is the most profound question that physics can pose. And tha….
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RT @potoyangroup: The #APS deadline for abstracts has been extended to Oct 31! This is an excellent venue to showcase your work if you work….
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RT @shaharsu: 📢New paper alert!! With @boothbylab @alexholehouse @fried_lab we take a look at how an entire proteome survives desiccation.….
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RT @MolecularCell: RNA-driven phase transitions in biomolecular condensates. In this review or our #RNA focus issue, @BanerjeeLab_UB and co….
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RT @MolecularCell: Our focus issue on RNA biology features reviews that explore the many faces of #RNA, diving into the processes mediating….
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RT @gable_wadsworth: Our review on RNA-driven phase transitions is up today at Molecular Cell! Check it out! @BanerjeeLab_UB .
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RT @brangwynnelab: How do you turn a condensate inside-out? Congrats to @sofiquinodoz & @jiang_lifei & co-authors on amazing study from our….
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Out today in @MolecularCell . Our review article highlights recent advances in ribonucleoprotein condensate biology, focusing on RNA-driven phase transitions. Efforts led by @gable_wadsworth and Sukanya Srinivasan.
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So glad to see this work in prints. RNA-based biomaterial are so exciting!! We @gable_wadsworth played a small role in this collaborative work with @JulieNguyenLab.
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