Hubrecht Institute
@_Hubrecht
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Utrecht
Joined June 2014
What if science truly is like volleyball, where teamwork and support are everything? We spoke with Francesca Mattiroli, who recently earned tenure, to explore this question and more. Read her inspiring story here 👉
hubrecht.eu
She always dreamed of becoming a scientist. Francesca Mattiroli, has passed tenure evaluation with flying colors. She will expand her chromatin research.
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On Jan 9, dr. Henriette van Beijnum defended her PhD on the regenerative abilities of the spiny mouse. Congratulations! Her findings, like the flexible “basket-weave” scar pattern, could help improve treatments for heart attacks and chronic wounds. See https://t.co/Ecd9WmJRMw
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Researchers from @BakkersLab have successfully repaired damaged mouse hearts using a protein from zebrafish. This study marks a promising step toward regenerative therapies to prevent heart failure. Read more https://t.co/9JFR2fXjYu
@DEMdeBakker
@BouwmanMara
@J_Bakkers
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Researchers from the @TheCleversLab developed a method to grow organoids using a bacterial protein: Invasin. The study, published today in @PNASNews, shows that Invasin offers a sustainable, affordable and animal-free alternative to current methods. https://t.co/16auPZDk8J
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How reliably is the epigenome passed from one cell to its daughter cells? @AlexandervanOu1, @jervdberg, @groth_anja & @Lleonie received a @novonordiskfond grant to answer this question, which will lead to new strategies to prevent disease and combat aging
hubrecht.eu
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The inaugural Hubrecht Symposium is on March 13th, 2025! Join an inspiring day on molecular & developmental biology. This annual event highlights the role of fundamental research in Dutch science. Free of charge! Submit your abstract by February 13th. See https://t.co/sKGYMwpiZo
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Congratulations to dr. Yasmine El Azhar, who successfully defended her thesis: Notch signalling dynamics during mouse development and homeostasis. She developed a mouse model to visualize real-time Hes1 oscillations in single cells @SonnenKatharina group. https://t.co/AvOnTdWbfc
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Exciting study by Amanda Andersson Rolf et al: In vitro expansion of a human fetal #pancreas #stemcell that generates all three pancreatic cell lineages”. https://t.co/mk4MdczkTM 1/
cell.com
Identification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and...
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📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: https://t.co/xcuc8drybh
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Researchers from @TheCleversLab created an organoid that mimics the human fetal pancreas. Unlike previous models, this organoid has all three key cell types. They also identified the stem cell that develops into these cells. Curious? https://t.co/Sm13BsXjWC
@AmandaARolf @Roche
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🧬New research published @NatureComms reveals how cells fix damaged DNA. Researchers from the @kind_jop group mapped repair proteins and show how they form 'hubs,' to coordinate repairs, almost like a 'repair café'. Learn more: https://t.co/3Ps1Qri1Ag
#DNARepair #SingleCell
hubrecht.eu
Research from the Kind Group reveals how proteins collaborate in 'hubs' to repair damaged DNA, advancing our understanding of cellular repair mechanisms.
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Researchers from the Mattiroli group discovered that DNA packaging in cells can directly impact the speed of DNA copying during cell division. The packaging sends signals through an unusual pathway, affecting the cell’s ability to divide and grow. More: https://t.co/Fgv1RynmHK
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Our position for tenure-track principal investigator is still open! As junior group leader you will develop your research line within our lively scientific community. Ready to establish your own research group at the Hubrecht Institute? Apply before 15-11! https://t.co/hXb5jz4Bee
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Researchers from the Organoid group have developed a new organoid model to study the origin of colorectal cancer. The researchers studied the sequential accumulation of mutations contributing to tumor formation. @HansClevers @Tom_Mizutani Read more here: https://t.co/0pLamFGI9p
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Francesca Mattiroli, group leader, receives a Vidi grant from the Dutch Research Council (NWO). With this funding, she and her team will investigate how DNA and its packaging are copied during cell division. Their findings could in the future help in fighting diseases and aging.
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Congratulations to all researchers on this great new paper in @ScienceMagazine, including @BeumerJoep @geurts_maarten @VeerleGeurts @NinoukAkkerman @DanielKruegerDK @JensPuschhof, in collaboration with @Roche @IHB_Research @MaastrichtU @UMCUtrecht
New @ScienceMagazine study in collab with @IHB_Research! We identified novel receptors on enteroendocrine cells (EECs) that regulate secretion of endogenous hormones. These harbor therapeutic potential for metabolic disease. Read the paper https://t.co/yycQFE72QY  or 🧵⬇️
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A team from the Organoid group and @IHB_Research @Roche has uncovered nutrient sensors on gut hormone-producing cells using organoids. The characterization of these sensors will help in treating metabolic & gut motility disorders. @BeumerJoep @HansClevers
https://t.co/8SWEOPoMZw
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Super happy to see this heroic effort by @DimitriFabreges and Bernat Corominas out! Via a quantitative atlas of the developmental trajectories of dozens of embryos, we can see how robust shapes and fates arise from highly stochastic cellular processes! https://t.co/kPVQFtRZrD 1/n
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