Christoph Maack
@ChristophMaack
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Comprehensive Heart Failure Center Würzburg - HF mechanisms in mitochondria, metabolism, EC coupling
Würzburg, Deutschland
Joined March 2015
All 4 reviews are OPEN ACCESS for 1 month at Special thanks to the team of @NatRevCardiol, in particular Dr. Gregory Lim! Please also visit our website & become member at @sfb1525 @Uni_WUE @DZHI_Wuerzburg
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Finally, in review #4 @dunjaaks @simon_sedej @PaillardMel @KatrinStreckf @EdoardoBertero @JeremyFauconni1 et al discuss how the imbalance between mechanical load and mitochondrial ATP supply induces a redox mismatch that drives #heartfailure progression.
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In review #3, @G_Vilahur @GhigoAlessandra et al. discuss how the interplay between #inflammation & #metabolism drives #heartfailure progression across etiologies & along the EF spectrum. In loving memory of Ioanna Andreadou
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In article #2, @liberale_luca @PKleinbongard et al. review the central role of coronary &systemic vascular dysfunction in #heartfailure (pEF&rEF), providing a mechanistic framework for therapies targeting the vasculature in different HF phenotypes.
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In review #1, Mathias Mericskay et al. discuss dysregulated substrate & intermediary metabolism and its role for post-translational modifications in #heartfailure (HFpEF&rEF). W/contr by @gabrieleschiat1 @Heatherlab_ox @BertrandLuc_ky @AnjaKarlstaedt .
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Our @COSTprogramme @EU_METAHEART CA22169 compiled a FOCUS ISSUE on METABOLIC ALTERATIONS in #heartfailure @NatRevCardiol. Read the editorial➡️& 4 Reviews outlined in thread⬇️@escardio @Soc_HrtVasMetab @AHAScience @DGKardio @dzhk_germany @ISHR_ES @ISHR_NAS
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Tolle Aktion heute von Stefan Störk &Team @DZHI_Wuerzburg im „Roten Bus“! 🚌 Früherkennung und Prävention der #Herzinsuffizienz sind Schlüssel zum Erfolg. @DGK_org @dzhk_germany @Herzmedizin_de @Herzstiftung
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Join us today at 2 pm CET for the first @ISHR_ES webinar of 2025! It’s all about metabolism in heart failure today! @DGK_org @escardio @dzhk_germany @YoungDgk.
Do not forget to join us this Friday, March 7th from 2pm - 3pm for the kickoff of the ISHR ES: 2025 webinar series the Beating Edge with this session having a focus on Cardiac Metabolism! . You can still register by scanning the QR code on the flyer👇. See you there!.
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Good luck, Eduardo! What a desaster. Glad you are safe!.
@dan_atar The neighborhood remains on military lockdown, but we were able to get in yesterday for 5 minutes with a police escort. This armored vehicle is among the many keeping us safe. Now back to evacuation, with hope that the fires (which are still raging) won’t cause further damage as
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Just arrived in beautiful Brussels and look forward to our @ISHR_ES Winter Council & Science Meeting - tune in via Zoom tomorrow (Wed) from ⏰13:00 CET on! @ISHR_ECI @IshrMci @ISHR_NAS @JMCCardiology @JMCCPlus @EU_METAHEART @dzhk_germany @DGK_org @escardio @AHAScience @YoungDZHK
Join us online Wed 8th Jan (Central European time ie UTC+1) for a cosy winter scientific symposium full of excellent cardiac science. #CardioResearch #ECR.@ISHR_ECI @IshrMci @ISHR_NAS @JMCCardiology @jmcc @BSCResearch
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Semaglutide normalises elevated Ca transients in cardiomyocytes of obese rats-could this be anti-hypertrophic? Nice collaboration btw @Vasconary Sequeira @DZHI_Wuerzburg &Uli Dischinger @medeinsUKW! @EU_METAHEART @ISHR_ES @DGK_org @dzhk_germany @escardio.
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Congratulations, Denise, and congratulations, Hannover!.
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Congratulations, Denise, and congratulations, MH Hannover!.
👏 Welcome back Denise‼️👍.
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That’s excellent! 💪🏼.
We're excited to share that #JMCCPlus has been officially accepted by @Scopus for indexing and citation metrics! You'll be able to find #JMCCPlus articles on #Scopus in the next few months and see our first #CiteScore in April/May 2025!. @ISHR_ES @ISHR_NAS @ISHR_AUS @ISHR_LAT
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In HCM, mismatch between ATP supply &demand oxidizes mitochondrial NADPH and increases ROS that trigger &sustain ventricular arrhythmias. Targeting mitochondria prevents VT/VF in HCM. Out on BioRx for now. @ISHR_ES @simon_sedej @IacopoOlivotto @dunjaaks @gabrieleschiat1 @DGK_org
Mitochondrial reactive oxygen species cause arrhythmias in hypertrophic cardiomyopathy #biorxiv_physio.
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Congratulations to @niels_voigt and his team for an excellent study! It was a pleasure to contribute!.
#ICYMI: Impaired Ca2+ buffering in persistent AF patients @funshofaks @niels_voigt.@dzhk_germany @SanuelSossalla @JordiHeijman @ChristophMaack @WillSeibertz @jrpronto @aiste_liutkute @haghighif @HubrichtD @niels_voigt.
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Morgen (Mittwoch) 17-18 Uhr wieder @DGK_org webinar zu #PlanetarerGesundheit, Thema „Luftverschmutzung und CV Gesundheit“ 🏭 🚗 ☁️ mit Jos Lelieveld und Barbara Hoffmann! @YoungDgk @YoungDZHK @KardiologieHH @Dominik_Linz @KlimaGesundheit @dgimev @thiele_holger Anmelden hier 🔽🔽.
Unsere neue #DGK WebinarSerie beleuchtet die "planetare Gesundheit" mit Fokus auf Herz-Kreislauferkrankungen. Lösungsansätze: individuelle Verhaltensänderungen, #kardiovaskulärePrävention, smarte Städteplanung. 📅 Nächster Termin: 10.07. ℹ️
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Mitochondrial Ca uptake: double-edged sword! Essential to match ATP supply &antioxidative capacity to demand, but harmful during I/R injury! Thank you @EdoardoBertero and Tudor Popoiu for this nice work! @ISHR_ES @EU_METAHEART @PaillardMel @JeremyFauconni1 @niels_voigt @MitOtalks.
Mitochondrial calcium in myocardial ischemia/reperfusion and cardioprotection.
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Very proud of my group @LabMaack with @DavidWeissmanm winning poster award at #ISHR-ES2024 and him &Anton Xu travel awards! Great talk also by Vasco Sequeira & poster presentations by Elsie Kajese, Katharina Ermer &Sarah Puhl! @ISHR_ES @ISHR_ECI @IshrMci @JMCCardiology @JMCCPlus
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Really nice session of our @COSTprogramme @EU_METAHEART #ISHR-ES2024! Very interesting presentations by @PaillardMel @KatrinStreckf, Ines Falcao Pires & @JolandavanderV4 and Moderation by Ioanna andreadou & @Heatherlab_ox. @ISHR_ECI @IshrMci @ECI_ISHR @ISHR_NAS @ISHR_AUS @CircRes.
This afternoon, our colleaugue, @PaillardMel gave a great talk on mitochondrial ion handling in heart failure! 👏 #ISHR-ES2024.@ISHR_ES @EU_METAHEART @LaboratoryIris
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