Eduardo Marban, MD, PhD
@MarbanLab
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Dr. Eduardo Marban | Executive Director, Smidt Heart Institute @SmidtHeart @CedarsSinai Views are my own, not institutional policy!
Cedars-Sinai Medical Center
Joined May 2021
.@CIRMnews has awarded @SmidtHeart researchers @LeferLab & @AleCiulloPhD more than $20 million to study potential treatments for #HeartFailure and an inherited type of heart disease #ACM 🔗
cedars-sinai.org
The California Institute for Regenerative Medicine has awarded Cedars-Sinai more than $20 million to study heart disease treatments.
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At today’s #labmeeting Adarsh Balaji related his work with @rrogerslab on #exomer TT1, which has fascinating bioactivity against #Duchenne in #mdx mice. More therapeutic options being developed for devastating myodegenerative disease of muscle and heart! @SmidtHeart @CIRMnews
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Thrilled that @CIRMnews has awarded us two major grants to advance #exomer #RNAdrugs towards the clinic: 1) @AleCiulloPhD on TY2 for #arrhythmogenic #cardiomyopathy; 2) @LeferLab combining TY1 plus #semaglutide in #HFpEF. Crossing the dreaded Valley of Death in drug development!
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Marking epic transition as Evan Zahn, founding director of congenital heart program @SmidtHeart, moves on to new pursuits. How often do you get to design and implement a novel care program from scratch? Seamless care from intrauterine life through old age, no handoffs. Amazing!
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Special privilege to share the podium today with @gracielagon and @AjhungMD this evening at the @CedarsSinai Annual Board Meeting, to share advances in #HealthAI at our institution. Special thanks to @MarbanLab for the photos!
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Great @SmidtHeart Frontiers in Heart Research seminar by @kdrosato of @uofcincy. Amazing that attenuation of glucose uptake can have such drastic benefits in #diabetic #cardiomyopathy!
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Stellar @SmidtHeart faculty-driven program, featuring the best of the best! Strongly recommended for anyone interested in cardiac imaging.
Just over a month left to register for our January 2026 three-day conference at Cedars-Sinai, “Advances in Nuclear Cardiology, Cardiac CT, and Cardiac MRI,” with some of the most well-known speakers in the field. View the course agenda and register at https://t.co/JlJwc9XzEl
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At #CVCT2025 I reviewed the nonlinear basic discovery arc underlying clinical development from autologous #CDCs #postMI to #deramiocel for #Duchenne #cardiomyopathy culminating in the blockbuster #HOPE3 trial by @Capricor. Odyssean journey! @SmidtHeart @CIRMnews @CoalitionDMD
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Join us in thanking chairperson @JoChikweMD, vice-chair @bnallamo and American Heart Association president @drstaceyrosen for bringing #AHA25 to life! We are grateful for their leadership and dedication to shaping the future of cardiovascular health.
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Day 1 of 12 Days of #ProBowlVote Giveaways! 🔁 Repost to win a signed Matthew Stafford mini helmet!
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🙏 Leandro for the invitation, and congratulations on your success @MonteHeart. As an alumnus of @CedarsCards, you make us proud! It was also great to see my friend and pioneering molecular cardiologist Rick Kitsis. @SmidtHeart
In case you missed the outstanding Grand Rounds by @MarbanLab at @MonteHeart you can see it here 👉🏻 https://t.co/tAYCVGhoyp
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We developed a drug discovery paradigm based on novel small RNAs from therapeutic extracellular vesicles. Started in 2019 and published this morning! Next stop, the clinic! @MarbanLab @AleCiulloPhD
https://t.co/CMJIeE3TRY
science.org
Up-regulation of three-prime exonuclease, TREX1, in macrophages enhances tissue repair post–myocardial infarction.
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Experimental Drug Boosts DNA Repair Response in Damaged Heart Tissue TY1 enhances the action of TREX1, a gene that helps #immunecells clear damaged DNA, helping to minimize scar tissue post heart attacks @MarbanLab @CedarsSinai
#DNArepair #cardiactissue
https://t.co/AD5pixYFBS
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Ecstatic to be senior author of this exceptional paper reporting the first #exomer, #TY1, a drug which I’m hopeful will change the way we practice medicine! Great team effort 🙏👍
Press release featuring @MarbanLab and my work on TY1, a synthetic small RNA drug bioinspired by the contents of therapeutic EVs. Grateful to be part of this disruptive work!
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🙏 No better time to revisit the origin story, told well in the video here: https://t.co/uUNeWxKq6h Special thanks to the late, great Ron Victor, who first sensitized me to the unmet needs of patients with #DMD #cardiomyopathy
cedars-sinai.org
Catherine Jayasuriya thought it was strange her then-6-year-old son, Dusty Brandom, seemed to fall down more often than other children and couldn’t keep up with his siblings. That year, 1998,...
As in the Grapes of Wrath, the road to cell therapy is littered with hulks of unrealized efforts. Deramiocel is a validation of long hard years of vision, honest work, uncompromising dedication, and (as with all things) good fortune. Congratulations @MarbanLab, no one deserves
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A 21 year journey of invention, discovery and mechanistic investigation yields the first therapy shown to improve both heart and skeletal muscle function in #Duchenne muscular dystrophy. @CIRMnews @NIH @CoalitionDMD @rrogerslab @A22002Mark @SmidtHeart
Breaking: Capricor is extremely pleased to announce positive topline results from our pivotal Phase 3 HOPE-3 clinical study evaluating Deramiocel in Duchenne muscular dystrophy. HOPE-3 met its primary endpoint and key cardiac secondary endpoint, with all Type 1 error–controlled
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Development of new #MinimallyInvasive #Technique to deliver #Biopacer - Great team work by James / @T_Ikenouchi / Ralf / Juan / Ed - @SmidtHeart @CedarsSinaiMed @CedarsSinai @MarbanLab #Biopace #CRM #rhythm #pacemakers ➡️ more to come soon!
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Appeasement: slippery slope to dictatorship? Northwestern reaches $75M deal with Trump administration to get federal funding reinstated
politico.com
The school expects federal funds will start flowing within days and be fully restored within 30 days.
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Honored to receive the AAEV Founder’s Award and to be inducted into the inaugural class of Fellow of AAEV at the 2025 @AAEV_org Annual Conference in Salt Lake City. Grateful to my team, collaborators, and the EV community for their support and commitment to advancing EV research.
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