Simon Sedej
@simon_sedej
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Associate Professor of ❤️ Physiology | Medical University of Graz | Cardiovascular research and longevity science | HFpEF | Fan of 🇸🇮 🏀 team.
Graz, Austria
Joined November 2016
In cardiometabolic heart failure with preserved ejection fraction the therapeutic efects of the NAD+ precursor nicotinamide include autophagy restauration. @ehj_ed @Mah_abdellatif @DiwanLabWustl @ProkeschL @sadoshju
https://t.co/8kPxlIUaJz
academic.oup.com
Metabolic cardiomyopathy is a major complication of obesity that often progresses to clinically evident heart failure with preserved ejection fraction (HFp
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New concept & changes to peer review to make it faster and more friendly: 👇 Unleashing the Power of the Beehive to Begin a New Era for JACC: Basic to Translational Science https://t.co/Mo1MgT0S3M This only works if you, our readers, authors and referees, embrace it!!
jacc.org
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Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF | Cardiovascular Diabetology | Full Text
cardiab.biomedcentral.com
Obesity is a modifiable major driver of heart failure with preserved ejection fraction (HFpEF), the most common and rapidly increasing form of heart failure. Current metabolic therapies, such as...
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Spread the word: The European Center for Angioscience @UniHeidelberg continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @Nature: https://t.co/B49wuaWYAE
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Our @COSTprogramme @EU_METAHEART CA22169 compiled a FOCUS ISSUE on METABOLIC ALTERATIONS in #heartfailure @NatRevCardiol. Read the editorial➡️ https://t.co/zDbjIUlD2V & 4 Reviews outlined in thread⬇️@escardio @Soc_HrtVasMetab @AHAScience @DGKardio @dzhk_germany @ISHR_ES @ISHR_NAS
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New content online: Adipose tissue ageing: implications for metabolic health and lifespan https://t.co/D1DXWHAI1J
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Nature Reviews Cardiology is delighted to be sponsoring poster prizes at the SHVM conference, and to have published a focus issue of articles on the theme of metabolic alterations in heart failure to mark the start of the meeting today: https://t.co/JwPRfnBYZh
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Here we are! Together with the colleagues from @COSTprogramme @EU_METAHEART, we dissected metabolic alterations in heart failure and prepared a focus issue in @NatRevCardiol! The 4 reviews are free to read for a month! Don’t miss this chance! Thx to @ChristophMaack
Our @COSTprogramme @EU_METAHEART CA22169 compiled a FOCUS ISSUE on METABOLIC ALTERATIONS in #heartfailure @NatRevCardiol. Read the editorial➡️ https://t.co/zDbjIUlD2V & 4 Reviews outlined in thread⬇️@escardio @Soc_HrtVasMetab @AHAScience @DGKardio @dzhk_germany @ISHR_ES @ISHR_NAS
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In review #1, Mathias Mericskay et al. discuss dysregulated substrate & intermediary metabolism and its role for post-translational modifications in #heartfailure (HFpEF&rEF). W/contr by @gabrieleschiat1 @Heatherlab_ox @BertrandLuc_ky @AnjaKarlstaedt
https://t.co/BrcvVA9UzT
nature.com
Nature Reviews Cardiology - In this Review, Mericskay and colleagues discuss the role of cardiac intermediary metabolism in heart failure, describing the perturbations in cardiac energy metabolism...
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🎥 How does fat metabolism shape how we age? ORF featured 'MetAGE' in a short TV clip on our research about aging and metabolism in cell models and patients. @UniGraz
@MedUniGraz 📺 Watch here (in German): https://t.co/wr1N5BG8Qe
#healthyaging #longevity #metage
on.orf.at
Erste Details aus dem Landessicherheitsbeirat | Debatte um mehr Jugendschutz im Internet | Aktuelle Krone-Umfrage zeigt FPÖ im Aufwind | Präsentation der Alternative zum Leitspital Liezen | Klasnic...
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Finally, in review #4 @dunjaaks @simon_sedej @PaillardMel @KatrinStreckf @EdoardoBertero @JeremyFauconni1 et al discuss how the imbalance between mechanical load and mitochondrial ATP supply induces a redox mismatch that drives #heartfailure progression.
nature.com
Nature Reviews Cardiology - In this Review, the authors focus on the tight interaction between cardiac mechanics and mitochondrial energetics, discuss how this mechano-energetic coupling is...
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BREAKING: MIT just completed the first brain scan study of ChatGPT users & the results are terrifying. Turns out, AI isn't making us more productive. It's making us cognitively bankrupt. Here's what 4 months of data revealed: (hint: we've been measuring productivity all wrong)
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👋 Meet Dr. Mahmoud Abdellatif @Mah_abdellatif – MetAGE key researcher @MedUniGraz He studies how aging affects the heart and vessels at the cellular&molecular levels – and how we could slow it down. https://t.co/0NgGtccr7C
#HealthyAging #HeartHealth #AgingResearch
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@KaitDennis19 et al found #FoxO1-zDHHC4-#CD36 S-acylation axis drives metabolic dysfunction in #diabetes. Learn more at https://t.co/9dqXx31whJ
@heatherlab.bsky.social @heather_ox @JussherLab @FullerLabGlas @dunjaaks @MarcosCG_95 @ujangpurnama
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𝗠𝗲𝗲𝘁 𝗠𝗲𝘁𝗔𝗚𝗘! 🎉 Researchers from Graz and Vienna team up to tackle ageing at the metabolic level — and shape a healthier future. Details 👉 https://t.co/o4iwEz0Liw
#HealthyAging #Metabolism #ScienceCommunity #AcademicLife #ResearchNetwork
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👥 Meet the people behind MetAGE! Researchers from 4 institutions - from basic science to clinical application - are joining forces to understand how metabolism shapes healthy ageing. Together, we’re driving innovation in ageing research. 💡#HealthyAgeing
https://t.co/o4iwEz0Liw
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@rau_thomas from the @MartinaS_lab presents an easy to use approach for whole-mount labeling and quantification of neuron- and vessel-density in adipose tissue in journal of cell science (JCS), @UniGraz
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One of the first publications resulting from our Cluster of Excellence by @MartinaS_lab and colleagues (including this beautiful cover image)! Check it out 👇 #MetAGE #healthyaging #longevity #microscopy #adiposetissue
Our article has been selected to provide the Cover image in the Journal of Cell Science! The beauty of the network of nerves and vasculature in adipose tissue. @sfb_immunomet @rau_thomas @UniGraz
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Here's what our research cluster does: We study how aging affects metabolism and vice versa – and what we can do to increase our healthy life span. #HealthyAgeing #MetAGE #ScienceToAction #longevity #translationalresearch
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