biorxiv_physio
@biorxiv_physio
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Moderate-Intensity Intermittent Training Inhibits miR-34a-5p to Reduce Prefrontal Cortex Apoptosis and Improve Cognitive Ability in . #biorxiv_physio.
biorxiv.org
Changes in microRNA (miRNA) play a role in brain aging. They are considered potential therapeutic targets. Regular long-term exercise benefits brain health. However, its exact mechanism is not fully...
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Mechanistic Insights into Sex Differences in Atrial Electrophysiology and Arrhythmia Vulnerability through Sex-specific Computational . #biorxiv_physio.
biorxiv.org
Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by notable sex differences in clinical presentation, treatment response, and outcomes. Although prevalence is similar...
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Beat-locked ATP microdomains in the sinoatrial node map a calcium-timed energetic hierarchy and regional pacemaker roles #biorxiv_physio.
biorxiv.org
Pacemaker myocytes of the sinoatrial (SA) node initiate each heartbeat through coupled voltage and Ca2+ oscillators, but whether ATP supply is regulated on a beat–by–beat schedule in these cells has...
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Intestinal catabolism of dietary fructose promotes obesity and insulin resistance via ileal lacteal remodeling #biorxiv_physio.
biorxiv.org
High-fructose corn syrup (HFCS) consumption is a risk factor for obesity and metabolic syndrome, yet the underlying mechanisms are incompletely understood. Catabolism of dietary fructose primarily...
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N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival #biorxiv_physio.
biorxiv.org
Histidine containing dipeptides (HCDs) such as N-acetylcarnosine are endogenous metabolites that are ergogenic and mitigate metabolic dysfunction. We previously demonstrated that short-term N-acety...
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Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice #biorxiv_physio.
biorxiv.org
Artery structural properties and Alzheimer's disease (AD) pathology are individually associated with impaired cerebrovascular function; however, the interaction of these factors is unclear. Further...
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The neuropeptide neuromedin U receptor nmur-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival #biorxiv_physio.
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A Machine Learning Approach to Predicting Dyspnea with Noninvasive Biomarkers #biorxiv_physio.
biorxiv.org
Rationale: Dyspnea is the subjective sensation of breathing discomfort. This symptom is highly prevalent in patients with chronic and critical illness, and its presence is associated with poor...
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Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis #biorxiv_physio.
biorxiv.org
Neutrophils, the first cells to arrive at the site of inflammation, are rather short-lived cells and thus have to be constantly replenished. During neutrophil development, vesicle dynamics need to be...
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SCAMP3 is essential for proper formation and function of neutrophil granules #biorxiv_physio.
biorxiv.org
Host defense functions of neutrophils during infection critically depend on microbicidal and proteolytic proteins stored in primary, secondary and tertiary granules that are released into the...
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Loss of brain insulin production impairs learning and memory in female mice #biorxiv_physio.
biorxiv.org
Diabetes is a metabolic disorder characterized by dysfunctional insulin release and action, and it is a risk factor for Alzheimer's disease, the most common form of dementia. Alterations in brain...
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Dysferlin Regulates Cardiac T-tubule Structure and Excitation-contraction Coupling in Isolated Cardiac Myocytes at Rest and in . #biorxiv_physio.
biorxiv.org
Dysferlin is a membrane-associated protein that supports skeletal muscle function such that mutations in the DYSF gene can cause muscular dystrophy. Growing evidence suggests dysferlin regulates...
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Phenological characterization of Mozambican native caprine breeds assessed through morpho-biometric traits and zoometric indices #biorxiv_physio.
biorxiv.org
This study aimed to characterize the morpho-structural traits of indigenous goats reared at the Chobela Research Station in the Magude District of southern Mozambique. A total of 135 goats were...
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High-salt diet modulates endocrine regulation between cortisol and FGF23 #biorxiv_physio.
biorxiv.org
Excessive dietary salt intake is a global health concern, affecting cardiovascular, renal, and bone health. While the renin-angiotensin-aldosterone system (RAAS) is a known regulator of dietary...
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Exercise induces time-dependent but not sex-specific transcriptomic changes in healthy human skeletal muscle #biorxiv_physio.
biorxiv.org
Elucidating the time-dependent transcriptional response of skeletal muscle to exercise is essential for uncovering the molecular mechanisms that drive its health-promoting effects. However, previous...
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Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling #biorxiv_physio.
biorxiv.org
Clinicians are often forced into the dilemma of whether to battle ocular inflammation or preserve vision imperiled by elevated intraocular pressure (IOP). Anti-inflammatory treatments utilizing...
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Beta Estradiol Receptor Modulates Liver Lipid and Ketone Metabolism #biorxiv_physio.
biorxiv.org
Non-selective hormone replacement with estradiol improves metabolic homeostasis during menopause. However, this treatment is not recommended for individuals with genetic predisposition to hormone-r...
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KneEZ Clear, an Effective Tissue Clearing Protocol to Study Musculoskeletal Tissues in the Mouse #biorxiv_physio.
biorxiv.org
Wholemount, 3-dimensional (3D) tissue imaging holds significant promise for analyzing heterogeneous musculoskeletal tissues, such as knee joints, that demand time- and labor-intensive processing...
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Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12 #biorxiv_physio.
biorxiv.org
Background: Advancing age is the strongest risk factor for cardiovascular diseases (CVDs), primarily due to progressive vascular endothelial dysfunction. Cellular senescence and the senescence-asso...
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Systemic Metabolic Rewiring in a Mouse Model of Left Ventricular Hypertrophy #biorxiv_physio.
biorxiv.org
Left ventricular hypertrophy (LVH) refers to the pathological thickening of the myocardial wall, and is strongly associated with several adverse cardiac outcomes and sudden cardiac death. While the...
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