Chii Jou (Joe) Chan
@ChiiJChan1
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Biophysicist in early mammalian development. PI/Asst Prof @MBIsg. Postdoc @EMBL from Hiiragi lab and @Prevedel_Lab, PhD @Cambridge_Uni @GuckLab
Singapore
Joined May 2019
Our lab's first venture into understanding fluid formation in ovarian follicles. Excellent work led by Kim Whye Leong and Yuting Lou, highlighting the importance of interdisciplinary approaches in life science. Come hear their talk #MBIMPG2025 @MBIsg today! https://t.co/I47ry3gSUV
biorxiv.org
A key process during mammalian folliculogenesis is the formation of a fluid-filled antrum around the oocyte. While it is known that the antrum is critical for oocyte maturation and the eventual...
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1/ 🎉Excited to share our new preprint @DMVlab @d_brueckner: "Self-organization of tumor heterogeneity and plasticity" https://t.co/pvubCvQWmW Tumor heterogeneity and plasticity drive metastasis and relapse. Which signals coordinate the patterning of cell states? A thread👇
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Biophysicists are realizing that there is an undervalued element at play in early development: Aside from genes, mechanical forces also steer the growth of embryos. @annademming reports:
quantamagazine.org
The same pulling force that causes “tears” in a glass of wine also shapes embryos. It’s another example of how genes exploit mechanical forces for growth and development.
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Check out our latest work on using quantitative micro-elastography to study 3D ovarian tissue mechanics during ageing. Thanks to Anna, Matt, Ali and Brendan for making this happen. Kudos to interdisciplinary science! https://t.co/qlpS505Gx9
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Here's an editorial for the theme issue https://t.co/Xq6ptS8p3W Check it out!
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Congrats to all poster winners!
Congratulations to our three poster prize winners for #MBIMPG2025! 🏆Rituraj Marwaha @marwaha_rr ; @tamal_das lab 🏆Boon Heng Ng @NgBoonHeng96 ; @ChiiJChan1lab 🏆Marie Cutiongco ; @wtzhaolab Thanks to all of the 115(!) poster presenters – our judges had a hard time deciding!
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Happy to share latest review from the lab: https://t.co/YVaqL3amEw. Stay tuned with our upcoming special issue on Environmental control of oogenesis and ovarian dynamics in Seminars in Cell & Dev. Biology!
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FINALLY! This was challenging to publish but we believe it is an important discovery: https://t.co/lN4KQqfIC6 💫Thanks to the amazing team 💫 @bis_was_here @Omar136661 @KyoohyunK Carsten Hoege Benjamin Lorton @RainerNikolay @MatthewKraushar
@DShechter @GuckLab @VasilyZaburdaev
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Fantastic work by @_Pulzar! See below the updated & published version of our paper on the mechanical dynamics of cells during Drosophila gastrulation - out now in @NatureComms! Congrats to the whole team - wonderful collaboration with the labs of @mleptin & Julio Belmonte 🥳🥂🙌
🥁 New article 📢: My #research on #Mechanobiology of #development in @NatureComms. We studied the mechanical dynamics of embryonic cell populations during #Drosophila #gastrulation using #Brillouin microscopy: https://t.co/xuk3jRjoWj
@Prevedel_Lab @embl. Highlights in thread⬇️
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Excited to be starting my research group as a tenure track Presidential Young Professor at the Mechanobiology Institute @MBIsg, and the Dept of Physiology at @NUSingapore in the fall! More about our work on vascular mechanobiology: https://t.co/2PDzYxiE5F
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Ever wondered how a tiny Hydra blob figures out where its head goes? Turns out, it's not just chemistry — it's feeling the stretch! Check out 👉 Mechanochemical patterning localizes the organizer of a luminal epithelium https://t.co/rEiG0EQz1m
#Hydra #morphogenesis #biophysics
science.org
A feedback loop between Wnt signaling and mechanical tissue stretching drives pattern formation in Hydra epithelia.
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We thought we were just studying mesoglea biogenesis…Turns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student @SohamBasu13! @EMBL #nematostella #morphogenesis
https://t.co/ymYXgc4f1d
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Three weeks left until the abstract submission deadline for our joint MBI-MPI #mechanobiology conference this September! @MBIsg @maxplanckpress To early career scientists- be sure to apply for a travel award to present your work! https://t.co/VDllpEDogf
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Excited to announce that MBI-MPG Conference 2025: Mechanobiology in Time and Space. Dates: 9-12 Sep 2025 Venue: Shaw Foundation Alumni House, NUS, Singapore Website: https://t.co/sDWv34JNx9 The deadline for early bird registration is May 31, 2025 Join us!
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🚨 Paper Alert 🚨 Absolutely delighted to share our last paper on "spatial mechano-transcriptomics" in @naturemethods👇!! https://t.co/pXXUUcqj4V
nature.com
Nature Methods - The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic...
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NIH cuts are hitting young scientists the hardest. By David Baker.
timmermanreport.com
[Editor’s note: David Baker gave this speech to Seattle community leaders Mar. 10, at a celebration of his 2024 Nobel Prize in Chemistry.] Let me just briefly tell you how innovation arises in...
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Dr Leong Kim Whye on “Critical phenomenon associated with luminogenesis during ovarian follicle development” #GCGP1st #Gerophysics
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Hello ovary-entusiasths, save the date for the 1st European #ovary workshop in the beautiful Lagos, Portugal on Feb 17-20, 2025 Have a look at our website to see the incredible line-up of speackers 🔗 https://t.co/7zGfUxXUz4 More info on your way, follow us!
europeanovaryworkshop.com
1st European Ovary Workshop - All About Ovaries
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