David Shechter
@DShechter
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Epigenetically engineering a kosher pig or how I stopped worrying and learned to love charge, grease, and intrinsic disorder Opinions are my own
Albert Einstein College of Med
Joined June 2012
Why can’t cells live without PRMT5? Our new transformative work inspired and led by @JacobRoth13 shows that this arginine methyltransferase is critical for histone production and genome stability. Full story: https://t.co/KzdnInZcEV 1/5
biorxiv.org
Histone proteins package DNA into nucleosomes, forming chromatin and thereby safeguarding genome integrity. Proper histone expression is essential for cell proliferation and chromatin organization,...
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Because the richest man in the world (and the owner of this site) spreads electoral bullshit nonstop, I want to tell you about my voting experience at my precinct in East Midtown Manhattan: - There's voter registry, and if you're not on it, you have to provide ID with proof of
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The United States should never have masked agents of the state stopping people on the street.
This is absolutely racial profiling. How are Americans OK with this? Masked men going up to women who have brown skin and asking if they were born here and where they’re from.
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New: The government does not track how often immigration agents hold Americans. So ProPublica did. We found more than 170 such incidents since the start of the second Trump administration.
propublica.org
The government does not track how often immigration agents grab citizens. So ProPublica did. Our tally — almost certainly incomplete — includes people who were held for days without a lawyer. And...
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Guy Gilboa Dalal and Evyatar David were deliberately starved so that they would become a “poster child of skin and bones.” That’s the horrific revelation shared by Guy’s brother, Gal, with Ynet. “Each time he tells something, we realize it was worse than we imagined.” “For
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It is extraordinary and heart-rending to see hostages returned to their families in Israel after their two-year ordeal in captivity. It is all so long overdue, and the world prays for sustained peace-building and continued healing in the region.
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Hamas is murdering Palestinians and already reneging on the deal.
Today has taken a bitter turn. Hamas says it will release only four bodies of hostages it murdered in captivity, out of 28. The hostage families say this represents a blatant breach of the deal by Hamas. They expect immediate immediate action to rectify this grave injustice.
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•Loss of arginine methylation results in splicing factor accumulation on chromatin •Sm tail methylation and SMN prevent aberrant snRNP DNA binding, enabling mRNA export
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https://t.co/DEBzWCvLZn Highlights: •Spike-in normalized RNA-seq reveals intron-rich, chromatin-detained poly(A) RNAs •Chromatin-retained RNAs are longer and splice slowly, preventing productive export
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GRAPHIC: Hamas terrorists execute Palestinians in Gaza City from the Doghmush family, claiming they were "Israeli collaborators." As usual, the "pro-Palestine" mafia is celebrating the barbarity of their favorite "resistance" group. Video just released. Save Gaza from Hamas.
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How does PRMT5 link splicing to mRNA export? Out in Mol Cell: by methylating Sm proteins, PRMT5 releases mRNAs that would otherwise remain trapped on chromatin. Meet GRIPPs: Genomically Retained Incompletely Processed Polyadenylated Transcripts. 🔗
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Hamas continues its brutal crackdown in Gaza. A short time ago, it executed Palestinians charged with allegedly collaborating with Israel.
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The moment Avinatan Or reunites with his parents and his girlfriend, Noa Argamani.
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this is their intention
So Pete Hegseth told the generals that we need to hunt and kill the enemies of the US, and the then a little bit later, Trump told the generals that American citizens are “no different than a foreign enemy” and said the military would be used against the “enemy within”
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I'm seeing quite a bit of comment about this, so I want to make a couple of points. I'm not owed eternal agreement from any actor who once played a character I created. The idea is as ludicrous as me checking with the boss I had when I was twenty-one for what opinions I should
“I think she’s going to find that you can’t sit on the fence... The real win is when ordinary people can say these things.” @DerryBanShee speaks to @joshxhowie about Emma Watson’s comments about JK Rowling. 📺 https://t.co/QFKNj0XXrH
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The indictment of James Comey over the objections of the Interim US Attorney's *own staff* and at the direction of President Donald Trump is a scandal of massive proportion. In any other time, with any other president, this would bring down the entire White House.
No one is above the law. Today’s indictment reflects this Department of Justice’s commitment to holding those who abuse positions of power accountable for misleading the American people. We will follow the facts in this case.
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The suspension of @jimmykimmel and the promise to silence other Late Night hosts for criticizing the administration should disturb everyone on the Right, Left, and Center. It’s wrong and anyone with a conscience knows it’s wrong.
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The liberal order created the most enduring free, peaceful, & prosperous societies in history. If/when it ever ends, it will be a tragedy for humanity — & the people who precipitated it, because they were bored with their middle class lives, will forever be remembered with infamy
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To my friends on the right: A few months after an assassination attempt on the Democratic Governor of PA, and 60 days or so after the assassination of a MN Democratic state legislator, if your reaction to yesterday’s assassination of a right wing media figure is “screw you Joe,
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I’ve been searching Bluesky to find people celebrating the assassination. The biggest account I found has 16K followers. There are probably others. But it seems like 100% of Democrats who matter in any way unequivocally condemn the killing. Maybe we should appreciate that?
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"The Left" did not kill Charlie Kirk. Talking like this is an attempt to silence critics of the Trump administration. No movement is responsible for crazy people. The only way you get something close to complete safety is strict gun control. https://t.co/4pTVHhzUfX
richardhanania.com
Charlie Kirk was shot and killed today while speaking at Utah Valley University.
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