Chao Wang
@ChaoWangBiochem
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Research Associate, Department of Molecular Medicine, The Scripps Research Institute
La Jolla, San Diego
Joined November 2018
1/ Thrilled to share an exciting discovery @ ChaoWangBiochem: Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9 #glycotime
biorxiv.org
Cancer treatment has been rapidly transformed by the development of immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1. However, many patients fail to respond, especially those with an...
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Mapping the chemical space of active-site targeted covalent ligands for protein tyrosine phosphatases https://t.co/DvYN65Xtwj
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The lab of @CarolynBertozzi discovered a biomolecule that could be present in all forms of life. "This is a stunning discovery of an entirely new class of biomolecules,” said Bertozzi. She is affiliated with @StanfordUChem @Stanford_ChEMH @StanfordMCHRI
https://t.co/XHaJ5Dhvds
news.stanford.edu
News, research, and insights from Stanford University.
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Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries https://t.co/omiPnbXUcr
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Will present our most recent work, including PARylation proteomics, PARP PROTAC compounds, PARP trapping, etc, at the PARP CSHL meeting. The talk will be in the PM session on Friday. https://t.co/NCCZ5o5TB9
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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I am excited to announce the publication of our work using phage display to engineer highly selective covalent inhibitors. This project started back in 2012 and it is very exciting to see it finally in print. Great work Shiyu, @scottlovell34 and others. https://t.co/qBEfeKtM4G
nature.com
Nature Biotechnology - Covalent inhibitors with high selectivity are rapidly identified by phage display.
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Such a nice perspective of FucoID by Dr. Elledge @BrighamWomens and a sweet title Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea) @SFGlycobiology #glycotime #immunooncology
cell.com
In this issue of Cell, Liu et al. present FucoID, a glycosyltransferase-mediated tagging platform, to biochemically label and capture antigen-specific T cells. With this technology, the authors...
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We have a postdoc opening starting in January, using FucoID to detect antigen-specific T cells in human cancer patient samples and in murine autoimmune disease models #glycotime #immunotherapy
SPOTLIGHT: Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation @scrippsresearch @pengwuTSRI Originally published in @CellCellPress. https://t.co/KdJiQerOV5
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1/3 What are the endogenous tumor antigen-specific T cells? What are their properties? Our magical fucosyltransferase-enabled FucoID help to address these fundamental questions #glycotime #immunotherapy @SFGlycobiology
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Prof. Sharpless and I will be hosting Yonghao for a seminar on 10/23
Will be visiting (virtually) Scripps Research Institute next week, and share our recent work on PARP and Poly-ADP-Ribosylation signaling. Thanks @pengwuTSRI for the kind invitation!
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Hening Lin, Maurine Linder & colleagues show that a palmitoylation/depalmitoylation cycle on STAT3 affects its subcellular localization and ability to promote TH17 cell differentiation and limit TH17-linked IBD @nature free-to-read: https://t.co/XASYAXGubh
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A gift from @JanSharpless. In the background, Antonella, me and Zach, three students @ScrippsGradPrgm. 19 years have passed. Time flies.
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This Wednesday, tune in to chat w/ Drs. Mary Cloninger (@montanastate) & @pumtiwitt (@MorganStateU) in our Meet the Speakers event! Ask them anything from research discoveries to career inspirations! This networking event is free to attend: https://t.co/Ssa64FIjFa
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Mouse secretome atlas using TurboID, from Jon Long's lab @Stanford! TurboID expressed in the ER lumen of 4 different cell types, & biotinylated proteins enriched from plasma & analyzed by MS. Dynamic profiling +/- high fructose/sucrose diet as well. https://t.co/OgzbRdRn2n
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St Jude is hosting some interesting Symposia this week! Transcription Therapy + Chemical Biology and Therapeutics.
stjude.org
This symposium features thought leaders at the interface of chemical and biomedical sciences, working in areas spanning therapeutic regulation of transcription and chromatin, computational biology,...
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Check out a viewpoint on Chemical Proteomics for Expanding the Druggability of Human Disease by @xzhang85 ! Great initiative by @ChemBioChem promoting rising stars in Chemical Biology!
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🗓️⏰ Reminder Don't miss Ruslan's Medzhitov @RMedzhitov Philinbiomed @philinbiomed seminar Wednesday September 23rd about "Homeostasis and inflammation in health and disease" The talk will be given via zoom For more details ⬇️ https://t.co/doshmIkG75
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Very excited to have this resource on our campus! Big congrats to Ben Shen @lab_shen for making it happen! Scripps Acquires Pfizer’s Massive Microbial Library
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The proteome‐wide potential for reversible covalency at cysteine #covalentwitter
onlinelibrary.wiley.com
Eine chemische Proteomikplattform, die Gelfiltration mit Aktivitäts-basiertem Protein-Profiling (ABPP) integriert, liefert eine Methode zur Bewertung niedermolekularer Elektrophile für reversible...
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