Look forward to speaking at the Biology and Engineering of the Cell Surface conference at the Janelia farm in a few weeks

3D fibrin gel-generated mechanical signalling allows robust expansion of stem-like CAR T cells within 4-5 days. Mechanical signaling via β2 integrin decouples T cell proliferation and differentiation for generating stem cell-like CAR T cells: Immunity

🎉 Our new paper on live, intracellular #ClickChemistry just posted in @NatureComms! Huge shoutout to lead author @KeqingN for all of the hard work 🙌🏼 Check it out 👉🏼 https://t.co/jDSGtnDBWx

Check out our recent efforts in @ChemRxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes. https://t.co/a4i3EHmQB2

We work very hard, even in the weekends🤗

Excited to hear new ideas on applying ecological concepts in microbiome and tissue cell community @MattiGralka @Karoline_Faust @pienta_brady @oventurelli2 @gibbological @MoEbrahimkhani @nika_shakiba Shaohua and David, and share our thoughts. Thanks @CellSystemsCP for the invite!

Gene expression in cells hasn't told us everything! Non-autonomous cis regulation of T cell anti-tumor immunity, via trogocytosis of glycoimmune checkpoints on myeloid cells #interaction Congrats to @pengwuTSRI @ChaoWangBiochem @scrippsresearch so glad to be a small part of it

DNA-encoded, Liquid Glycan Array (LiGA) and its application to cell-surface profiling is out in @NatureProtocols . Big thanks to @miratsojitra for leading the effort and @MatthewMacaule4 + members of Macaluley Lab and @derda_lab !

Amazing work to include glycosylation in protein structures

6/ Special thanks to @MatthewMacaule4 for the new Siglec constructs that made this study possible! #Collaboration #GlycoImmunology

5/ This degrader is the first agent capable of inducing simultaneous degradation of two membrane receptors, achieving maximum therapeutic benefit!

4/ The therapeutic effect of the Siglec-7/9 degrader is comparable to that observed in SIGLEC-E knockout mice, marking a significant advance in targeting glycoimmune checkpoints. #CancerImmunotherapy

3/ Nearly quantitative degradation of Siglec-7/-9 was observed in both cell lines and primary cells. In vivo, degradation was 50-85%, yet efficient tumor control was still achieved in all tumor models! 🎯

2/ Compared to antibody/nanobody-based degraders that induce only partial membrane protein degradation (<70% in most cases), our Siglec-7/9 degrader shows significantly better efficacy. 💥 #ProteinDegradation

1/ I’d like to add a few more comments to our discovery: Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9!

Tour-de-force application of SuFEx click chemistry in ligand optimization and glycobiology discovery led by @ChaoWangBiochem from the @pengwuTSRI lab! 🥳

Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds

14/ @ChaoWangBiochem is on the job market, searching for a faculty position now!

13/ This study highlights the importance of considering extrinsic checkpoints acquired by T cells in the TME when selecting checkpoint blockade therapies. #CancerResearch

12/ These findings underscore the potential of Siglec-7/-9 depletion as a promising therapeutic intervention that reprograms both innate & adaptive immunity for cancer treatment.