Chris Parker
@_chrisgparker_
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Professor @scrippsresearch | Department of Chemistry | chemical biology & chemical proteomics
San Diego, CA
Joined May 2018
Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation. Nice work Wesley and Roy!.
pubs.acs.org
ConspectusProtein acetylation is a pervasive and reversible post-translational modification (PTM) that impacts various protein features including stability, localization, and interactions and...
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Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews.
biorxiv.org
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacol...
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RT @DanNomura: Really cool @biorxivpreprint from @xzhang85 on expanding the repertoire of chemically induced covalent neo-antigens! https:….
biorxiv.org
The ubiquitin-proteasome system generates peptide fragments that are displayed on MHC-I molecules. Recent studies revealed that covalent small molecules can hijack this process, leading to the...
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A big congratulations to the newly minted Dr. Forrest @InesForrest . Super proud!
Proud to share that I have officially completed my PhD and graduated from @scrippsresearch! 🥳 . Grateful to my mentors, collaborators, friends, and family for their support throughout this challenging yet rewarding and unforgettable journey! 🧬 . Excited for the next chapter! 🎓
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We designed a library of function-biased, target agnostic bifunctional molecules and profiled them proteome wide for their ability to degrade proteins. We believe this study provides a proof of concept to expand PROTAC strategies beyond targets with well-established ligands.
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Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @InesForrest .
biorxiv.org
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among...
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RT @DanNomura: I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just….
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Check out our recent efforts in @ChemRxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes.
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RT @scrippsresearch: Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from @….
magazine.scripps.edu
In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps...
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Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds.
Chemical proteomic mapping of reversible small molecule binding sites in native systems
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RT @StephanHacker2: Great paper by the group of @_chrisgparker_. They further developed their AceTAG technology to also recruit the lysine….
pubs.acs.org
Post-translational modifications (PTMs) dynamically regulate the critical stress response and tumor suppressive functions of p53. Among these, acetylation events mediated by multiple acetyltransfer...
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RT @bethylacetate: the first project of my PhD is now out @J_A_C_S !.super proud to introduce ABAP (my first acronym!) and share our findin….
pubs.acs.org
Lysine acylations are ubiquitous and structurally diverse post-translational modifications that vastly expand the functional heterogeneity of the human proteome. Hence, the targeted acylation of...
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RT @abbey_e_reeves: Proud to share my first, first-author paper of graduate school! This year-long detour started with “we made a neat tool….
pubs.acs.org
The differentiation of placental cytotrophoblasts (CTBs) into the syncytiotrophoblast (STB) layer results in a significant remodeling of the plasma membrane proteome. Here, we use a peroxidase-cata...
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RT @giuliosf: We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of….
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RT @EvertNjomen: Excited to share a key part of my postdoctoral work in the Cravatt lab at @ScrippsResearch, published today in @NatureChem….
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RT @MJNiphakis: Excited to share this @CellChemBiol Review I wrote with Ben Cravatt highlighting recent applications of ABPP for ligand dis….
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RT @InesForrest: Very honored to be one of 19 graduate students recognized by the @AmerChemSociety and @ACSGradsPostdoc for leadership in t….
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Happy to share new work led by recent grad @AnnyChe77788549 and @SinghaSoumya. Here, we expanded our AceTAG platform to include PCAF/GCN5 & used this toolbox to investigate functional consequences of targeted p53 acetylation. w/@Michael_A_Erb. @ACSBioMed
pubs.acs.org
Post-translational modifications (PTMs) dynamically regulate the critical stress response and tumor suppressive functions of p53. Among these, acetylation events mediated by multiple acetyltransfer...
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RT @Jacob_srd: No 1⃣1⃣ Check out this intriguing mechanistic study on dialkyldiazirines by @FoxGroupUD (@UDelawar….
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RT @scrippsresearch: Congrats to Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, on receivi….
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