Chris Parker
@_chrisgparker_
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Professor @scrippsresearch | Department of Chemistry | chemical biology & chemical proteomics
San Diego, CA
Joined May 2018
What can you degrade if you bifunctionalize the CRBN binder to an agnostic chemical library? Turns out a lot of proteins! Read this fascinating work below led by the talented @InesForrest , Ph.D and colleagues at Scripps on their approach using AgnoTACs. https://t.co/6GbyMmTJER
pubs.acs.org
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among...
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Check out the final version now out in @ACSCentSci ! https://t.co/YqzBQD3413
pubs.acs.org
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among...
Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @InesForrest .
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This was a big team effort - congratulations to all the authors!
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Check out our recent collaboration with @abbvie in @CellChemBiol. We identifed compounds that potently clear tau aggregates. After chemoproteomics and functional studies, we found it covalently targets ER protein P4HB (after metabolic activation).
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See our finalized version now out in @angew_chem! https://t.co/2kBJAG4y4H
onlinelibrary.wiley.com
Herein, we exploit the inherent structural complexity of natural products (NPs) to access a unique library of photoaffinity (PA) probes, which we term fully functionalized natural products (FFNPs)....
Check out our recent efforts in @ChemRxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes. https://t.co/a4i3EHmQB2
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Happy to share our contribution to this special issue dedicated to "Proximity-Induced Chemical Biology". We provide our take on targeted protein acetylation. Nice work Wesley and Roy! https://t.co/Gp4ggeZIh1
pubs.acs.org
ConspectusProtein acetylation is a pervasive and reversible post-translational modification (PTM) that impacts various protein features including stability, localization, and interactions and...
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Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with @ForliLab, @HuangMia & @bmsnews.
biorxiv.org
Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacol...
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Really cool @biorxivpreprint from @xzhang85 on expanding the repertoire of chemically induced covalent neo-antigens!
biorxiv.org
The ubiquitin-proteasome system generates peptide fragments that are displayed on MHC-I molecules. Recent studies revealed that covalent small molecules can hijack this process, leading to the...
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A big congratulations to the newly minted Dr. Forrest @InesForrest . Super proud!
Proud to share that I have officially completed my PhD and graduated from @scrippsresearch! 🥳 Grateful to my mentors, collaborators, friends, and family for their support throughout this challenging yet rewarding and unforgettable journey! 🧬 Excited for the next chapter! 🎓
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We designed a library of function-biased, target agnostic bifunctional molecules and profiled them proteome wide for their ability to degrade proteins. We believe this study provides a proof of concept to expand PROTAC strategies beyond targets with well-established ligands.
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Happy to share a new preprint from our group in collaboration with AbbVie led by graduate student @InesForrest .
biorxiv.org
Targeted protein degradation (TPD) is an emergent therapeutic strategy with the potential to circumvent challenges associated with targets unamenable to conventional pharmacological inhibition. Among...
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I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
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Check out our recent efforts in @ChemRxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes. https://t.co/a4i3EHmQB2
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Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from @AmerChemSociety for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.
magazine.scripps.edu
In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps...
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Check out our recent Opinion in @TrendsinPharma on chemical proteomic binding site determination for non-covalent compounds
Chemical proteomic mapping of reversible small molecule binding sites in native systems https://t.co/Ft9Sp4r4xm
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Great paper by the group of @_chrisgparker_. They further developed their AceTAG technology to also recruit the lysine acetyltransferase PCAF/GCN5. Together with their p300/CBP recruiter, this allowed in-depth insights into the function of p53 acetylation
pubs.acs.org
Post-translational modifications (PTMs) dynamically regulate the critical stress response and tumor suppressive functions of p53. Among these, acetylation events mediated by multiple acetyltransfer...
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the first project of my PhD is now out @J_A_C_S ! super proud to introduce ABAP (my first acronym!) and share our findings on how lysine acetylation modulates protein function & interactions. so surreal to see this in print https://t.co/mry3BdSnOY
pubs.acs.org
Lysine acylations are ubiquitous and structurally diverse post-translational modifications that vastly expand the functional heterogeneity of the human proteome. Hence, the targeted acylation of...
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Proud to share my first, first-author paper of graduate school! This year-long detour started with “we made a neat tool - what biology can we figure out with it?” Turns out we can find regulators of placental cell differentiation.
pubs.acs.org
The differentiation of placental cytotrophoblasts (CTBs) into the syncytiotrophoblast (STB) layer results in a significant remodeling of the plasma membrane proteome. Here, we use a peroxidase-cata...
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We are excited to kick off our series of 4 manuscripts from the RESOLUTE consortium by sharing the metabolic mapping of the Solute Carrier Superfamily ( https://t.co/OAn581qvIN)!
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Excited to share a key part of my postdoctoral work in the Cravatt lab at @ScrippsResearch, published today in @NatureChemistry! Huge thanks to collaborators @brumelillo, @_RachelHayward, @VividionRx, and all coauthors.
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