Lukas Cermak Lab
@CermakLab
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We want to be there when protein is broken down and cullins are present. #ubiquitin #ubiquitin_ligases #mouse_models
Prague
Joined May 2022
Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration!
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RT @HanaSedlackova1: 📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent….
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Huge congrats to @yadav_anoop101, @aabdirov1, and @KatarinaOndrusk for their fantastic contributions to this elegant study! @imgprague @BFUavcr @CzechAcademy #DNAreplication #CancerResearch #proteasome #ubiquitin.
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CRL4-DCAF12 fine-tunes replication by degrading MCMBP, enabling proper MCM assembly and accurate replication speed. Without it? Faster forks, DNA damage, instability—and a cancer risk.
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What a wonderful, inspiring, and collaborative meeting at #EMBOubiquitin2024! In 1998, I attended my first conference—same #Cavtat, same @iDikic2. Huge thanks to the organizers @YMerbl, @YKulathu, @LabJoazeiro, @polosimona1, and @EMBOevents!
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Fantastic work by @NikolDibus and an excellent collaboration with Michele Pagano @paganolab and Ondrej Stepanek @AdaptiveImmuni2! Hopefully, more journals will endorse papers focused on addressing the confusion published across all levels.
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🔬 Join our research team! 🎓 Explore the vital role of the proteasome in cancer cell apoptosis. 🧬Seeking passionate PhD candidates in molecular biology. 🧪#PhDPosition #CancerResearch #MolecularBiology.
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RT @paganolab: Do papers improve after peer review? Only in a limited number of cases. Is it still worth the effort? Let’s eliminate the t….
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RT @HanaSedlackova1: A postdoc position is available in our lab 🔬. If you are interested in DNA replication & genome stability, please get….
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Great talk at @imgprague by Vincenzo D'Angiollella @VdangioE3lab on #neomorphic substrates and his own Cyclin F. It's always a blast to meet other Pagano lab @paganolab alumni.
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First author Nikol Dibus @NikolDibus .had dedicated her doctoral life to FBXO38, so far the only CUL1-dependent substrate receptor mutated in a hereditary form of neuromuscular atrophy. I can see more great stories coming out about this unique ubiquitin ligase.
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Great collaboration with Ondrej Stepanek @AdaptiveImmuni2 and Michele Pagano @paganolab on this developing story. For more information, follow @paganolab .
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RT @_AntonioMarzio: 🚨 📢 My lab is looking for a highly motivated Research Associate to join our team @WCMCPathology @WeillCornell ! Learn….
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RT @paganolab: Just received more pics of the Retreat from various alumni. Why don't you move all back to NYC? 😪 At least @_AntonioMarzio….
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