Ben Diamond, MD
@BenDiamondMD
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Assistant Professor, Myeloma Institute @SylvesterCancer. Former @MSKCancerCenter chief fellow. Opinions expressed are my own.
Joined October 2018
Out in @Blood! Years of collaboration between @Sylvester @MSK @NYU. With @BachisioZic @FrancescoMaura4 @DrOlaLandgren, we reconstruct evolution of clonal hematopoiesis (CH)➡️ therapy-related myeloid neoplasm (tMN). #mmsm #leusm #chipsm
https://t.co/tYJTCFDrKt (1/15)
ashpublications.org
Key Points. Autologous transplantation allows clonal hematopoiesis to escape mutagenic chemotherapy and be reinfused to expand to neoplasm.Distinct chemoth
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Excited to share new study out today on @JCO_ASCO where we leveraged #WGS to reclassify MGUS and SMM and define the concept of "malignant transformation" @MSKCancerCenter @LaStatale @MDAndersonNews @MoffittNews @SylvesterCancer @nyulangone @sangerinstitute @MayoClinic #mmsm 1/14
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#Myeloma Paper of the Day: LYNX study of subcu dara + car/dex (D-Kd) vs. Kd in pts with relapsed/refractory myeloma who received previous daratumumab shows no significant differences in ≥VGPR rates between treatment groups: https://t.co/tzEo2Ix1JM. Is repeating dara dead? #mmsm
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#Myeloma Paper of the Day: High CTC levels associated w/ high-risk features (ISS or IMS/IMWG 2024), complex genomics (chromothripsis, APOBEC mutagenesis, and loss of key tumor suppressors), and are a surrogate for PR transcriptomic signatures: https://t.co/90yIDW5a6u.
#mmsm
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Elevated circulating tumor cells [#cactc] reflect high proliferation and genomic complexity in multiple myeloma [Sep 23, 2025] Garces et al. @Hemasphere_EHA
https://t.co/R8ehW89OIV
#mmsm #cagenome
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It was a real pleasure to work on this collaborative piece. Big thanks to @juanjogrcs for leading the charge and guidance of @TomasJelinekMD and @FrancescoMaura4 !
As we promised, finally the paper is out! 👉Elevated #CTCs reflect high proliferation and genomic complexity in #mmsm
https://t.co/VgFEyFNLOq
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Check this out today! Great collaboration with @TomasJelinekMD @juanjogrcs @BenDiamondMD @MSKCancerCenter @OsuChsd @univmiami @theMMRF #mmsm #wgs #IMS25 - paper coming out soon….
Do you want to know why #CTCs in #mmsm have the power of enhancing risk indexes or stratifying systems? Stop by our poster at #IMS25 👉 PA-231!
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Sylvester researchers discovered that cyclin-G associated kinase (GAK) is essential for diffuse large B-cell #lymphoma (DLBCL) cell survival, revealing a promising new drug target through an innovative platform they developed. Congratulations to @DrJonSchatzMD and Dr. Hassan Al
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#Myeloma Paper of the Day: Study looking @ genomic antigen loss timing in myeloma treated w/ T-cell redirection finds biallelic loss driven by events after BCMA/GPRC5D CAR-T/TCE; in 752 NDMM pts 2.7% & 9%, respectively, had monoallelic inactivation: https://t.co/mmiAEhGWL9.
#mmsm
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Thank you for the great submission process and beautiful cover art! Link to tweetorial here:
Online First: Mutagenic Impact and Evolutionary Influence of Chemoradiotherapy in Hematologic Malignancies https://t.co/onEEiIpipB
#MMsm #cancergenomics @BenDiamondMD @FrancescoMaura4 @DrJonSchatzMD @MichaelDJain @Dhanvantri_Cha
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Excited to share our new paper, out today on @NatureGenet where we use 421 #WGS to reconstruct the evolutionary history of multiple myeloma #mmsm (🔥🔥). Great collaboration with @HDMyeloma @SylvesterCancer @MayoClinic @MSKCancerCenter @MSK_DeptOfMed .
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#Myeloma Paper of the Day: Targeting w/ talquetamab as bridge to BCMA CAR-T shows no grade ≥3 CRS, 2% grade 3 ICANS & grade 1-2 talq unique toxicities, 71% ORR, post CAR-T 88% responded/54% CR, 2 grade ≥3 CRS, 1 grade 3 ICANS, 5% grade ≥3 infxns: https://t.co/GemPoeEe3h.
#mmsm
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NEW STUDY ONLINE Tocilizumab Prophylaxis for Patients with Multiple Myeloma Treated with Bispecific Antibodies #mmsm @IMFmyeloma @theMMRF @HealthTree @ASH_hematology @SylvesterCancer @univmiami
ashpublications.org
Key PointsWithout compromising efficacy, a single dose of prophylactic tocilizumab resulted in low rates of CRS (10.1%) and ICANS (5.9%).It decreases resou
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Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma [May 10, 2024] @RossFirestone et al. @BloodJournal
https://t.co/5YM5VsqUSN
#CARTcell #ImmunoOnc #mmsm HT @szusmani
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🚨 New paper in @NatureGenet ! How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here!
nature.com
Nature Genetics - Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds...
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Biallelic Antigen Escape is a Mechanism of Resistance to Anti-CD38 Antibodies in MM - @FrancescoMaura4
@BloodPortfolio @BenDiamondMD @lbaughn @MayoMyeloma @Rfonsi1 @NBahlis @myelomaMD @RaabMarc
https://t.co/DLbVSGiWgL
#OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter
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Our lab fantastic postdoc @juanjogrcs will present today our study on CTC in multiple myeloma @mmsm. Several relevant findings by linking WGS, RNAseq and CTC. Great collaboration with @TomasJelinekMD @BenDiamondMD @szusmani @MSKCancerCenter @OsuChsd @univmiami @theMMRF #mmsm
Almost ready to present our work about #CTCs at #EHA2025, come to learn about how #liquidbiopsies can change the paradigm of #mmsm!
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Thanks for highlighting this work!
#Myeloma Paper of the Day: Biallelic antigen escape may be mechanism of resistance to anti-CD38 antibodies; L153H & C275Y decreased binding affinity & ADCC of daratumumab & isatuximab while a 3rd, R140G, conferred selective resistance to dara only: https://t.co/HqSryeqLMd.
#mmsm
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Our CD38 resistance story is out in @BloodPortfolio. We had a great time putting this one together. Big multi-institutional collab!
Happy to share our new work out today on @BloodPortfolio #Blood where we report CD38 loss as recurrent mechanisms of resistance to anti-CD38 antibody in multiple myeloma. Great collaboration between @MSKCancerCenter @MSK_DeptOfMed @UCalgary @HDMyeloma @MayoClinic #mmsm #wgs
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Great experience working with the team @BCD_AACR !
Mutagenic impact and evolutionary influence of chemo-radiotherapy in hematologic malignancies: https://t.co/cKYQaYGYnW
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This was a privilege to work on. Big thanks to all of our co-authors and collaborators for supporting the effort!
Excited to share our work investigating the mutagenic impact of radiotherapy in hematological cancers out today in @BCD_AACR!! 🎉 Another study born from amazing collaborations across @MoffittNews @HDMyeloma @univmiami @MSKCancerCenter @MSK_DeptOfMed 💪 #lysm #wgs #RT #mmsm
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