Aydogan Lab
@AydoganLab
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We study principles of biological time control with a focus on the emerging concept of autonomous clocks. Columbia University & HHMI
New York, NY
Joined November 2019
EXCITED to unroll this 🧵 on our new story on the metabolic licensing of animal development... How did we even get here..? https://t.co/Z5mhTtLGde Early embryo is thought of a pre-set machine that's set to go once it's fertilized - check out this gorgeous 📽️from Phil Keller!
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The Gonzalez Lab at Columbia University is seeking a scientific leader! Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes. Apply: https://t.co/84JwVnrhS1
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Two back-to-back stories on mitosis led by my incredible postdoc @KrunoVuk at @institutrb, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @NatureComms
https://t.co/oUwguXWRUN
https://t.co/bCnHSvthbQ
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We are accepting applications for 2 tenure track faculty positions at UTSW in the Department of Cell Biology! Apply before October 31st!
📢The Department of Cell Biology is hiring! We have two tenure track faculty positions open. See below for more information and how to apply. 🧫🧪🔬 https://t.co/IOLfW6pfco
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If you’re around in NYC, and studying microtubules or mitosis, this one is not to be missed!
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Excited to share our new paper! mtDNA mutations contribute to mitochondrial disease and aging only if they rise in abundance. We show that deleterious mutations reach high abundance by hitchhiking on genomes that have a replicative advantage https://t.co/Pqahch5qe5
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Here’s to all my colleagues rocking bowties! Happy #BowtieDay! Shoutout to @SandyBoynton for the image. #Style #WorkLife
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If you're finishing PhD soon and thinking of postdocs, see below! Especially if you're keen on combining biochemistry, imaging and cell biology, we are onto some exciting findings on molecules and mechanisms underlying a cytoplasmic division cycle autonomously of CDKs!!
#Postdoc opportunity at Columbia U. in New York! We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU! https://t.co/bNBHILsmJr
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#Postdoc opportunity at Columbia U. in New York! We are interested in candidates from biochemistry backgr. & excited about fractionation, purification and reconstitution to study autonomous clocks in the cell cycle, in colab. w/ @Aydinlab at NYU! https://t.co/bNBHILsmJr
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🚨Thrilled to announce I will be presenting our work at the Cold Spring Harbor Genome Engineering: CRISPR Frontiers Meeting (@CSHL) Aug 12–16! 🧬✨ We're combining cutting-edge in vivo CRISPR strategies with cancer research to uncover how mutant p53 drives metastasis—mutation by
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I think a good rule of thumb is to spend at least as much time thinking about your data as you did obtaining it. It's common for people to spend a lot less time thinking than doing which gives rise to all kinds of problems.
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I'm pleased to share this work now published in @PLOSBiology! Since our preprint, we've uncovered exciting new links connecting CCDC66 to actin, vesicular trafficking, and Wnt signaling, and revealed how these contribute to CCDC66's ciliary functions. See link below!
New preprint alert! We've uncovered the role of the microtubule-associated protein Ccdc66 in maintaining the stability and disassembly of the primary cilium. Our findings reveal how Ccdc66 depletion leads to unstable cilia and affects signaling pathways like Hedgehog and Wnt.
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In case this is not obvious: Expecting to understand and predict human biology based solely on modelling nucleic acids is naive. It’s unrealistic.
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Join the #VosshallLab as a postdoctoral scientist! Fully funded position in New York City @RockefellerUniv
https://t.co/XfhsO4j5h0
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I’m happy to share that my latest PhD work is published in @embojournal! We demonstrate a fundamental role for Annexin A5 in regulating mitochondrial calcium signaling and apoptosis. https://t.co/DAbdgDz1LV
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🚨New paper alert!🚨 Our latest work uncovers how cells detect and destroy defective ribosomes before they cause harm. A key quality control pathway with implications for development and disease. #ribosome #qualitycontrol Check it out in Molecular Cell: https://t.co/3MonF97oTC
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This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach
https://t.co/Gh8fUhDeP7
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Our review on genetically encoded CDK biosensors is finally out in CSF! Take a look!
jstage.jst.go.jp
Cyclin-dependent kinases (CDKs) orchestrate cell cycle progression through precise temporal control of substrate phosphorylation. While traditional bi …
【早期公開】@goto_yuhei さんによる総説です!J-STAGE Articles - Capturing CDKs in Action: Live-Cell Biosensors Pioneer the New Frontiers in Cell Cycle Research https://t.co/IcHxrjxPbR
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Hello everyone! I am helping to organize a one-day symposium on fluorescent metabolite biosensors and their use in metabolism research. It will be May 12-13 and associated with the Cold Spring Harbor Laboratory “Mechanisms of Metabolic Signaling” Symposium. Our field needs to be
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Excited to share this review on chromatin-metabolism crosstalk, lead by our star student Varun Sahu. Here, Varun summarizes the molecular principles governing metabolite-chromatin interaction & highlights emerging technologies that could advance the field. There’re lots to learn!
In this review for our focus issue on patterns in molecular biology, @LuLaboratory explores how metabolites and metabolic enzymes regulate chromatin and histone modification patterns, highlighting the crosstalk between the metabolome and the epigenome. https://t.co/wRBWwxFBif
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