Tychele Turner
@tycheleturner
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PhD Human Genetics & Molecular Biology, PI @TNTurnerLab @WashUGenetics, Tweets/views are my own.
Joined October 2015
Thank you to @NIMHgov for funding my R01 on noncoding variation in neurodevelopmental disorders! @TNTurnerLab @WashUGenetics #genetics #genomics #autism So Very Happy!!!.
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This is my 1000th tweet on Twitter. If I get greater than 1000 likes on this tweet I will donate $1000 to @American_Heart. My dad just had radical open heart surgery for a cardiac defect and as a researcher myself it was amazing to see the incredible advances for #heart medicine!.
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Recently, I’ve been asked about good tools for plotting variants on proteins. I currently use .MuPIT (.Protter ( .DOG (.See pics for examples from my lab’s recent papers. #genomics #protein @TNTurnerLab
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Today is the first day of the Turner Lab in the Department of Genetics at Washington University School of Medicine. I cannot wait to get started! #TNTurnerLab #genetics #genomics
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After 61,027 miles, 25 flights, 4 shuttle buses, 27 interview days, 8 research talks, and 6 awesome offers; I will officially be starting my human genetics laboratory at Washington University in St. Louis, Missouri in the fall of 2019. #ILikeNumbers #genomics @WashUGenetics.
We are thrilled to announce that @tycheleturner, Ph.D., will join our faculty as Assistant Professor of Genetics in Fall 2019! Read more about Tychele and her research here: #WashUGen
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Excited to share that denovo-db is now available on @ZENODO_ORG (! The new version of denovo-db contains >1 million de novo variants from published data on >70,000 individuals. After much thought, this feels like the right step for sharing with the
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Thank you to @NIMHgov for funding my K99! I am very excited to train with mentor Evan Eichler and co-mentor @JShendure and to collaborate with Len Pennacchio, @daniela_witten, and Raphe Bernier as part of this work.
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Our paper "Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders" is online @AJHGNews Thankful to wonderful collaborators @UW @AllenInstitute @GeneDx and funding @NIMHgov @AutismScienceFd ! #neurodevelopment #autism #genomics #genetics.
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Just heard about the passing of Dr. Debbie Nickerson. Debbie was also a mentor to me, during my time as a postdoc in the Eichler laboratory at the University of Washington. She was an amazing, leading scientist and will certainly be missed in the world of genomics.😢.
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Celebrating the upcoming one-year anniversary of opening the @TNTurnerLab @WashUGenetics and a new preprint led by graduate student Evin Padhi (@EvinPadhi)! We thank our many wonderful collaborators who worked with us on this study #autism Tweet 1/2.
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Having fun perusing some new data I generated in the @TNTurnerLab . @PacBio sequencing on a cell line. Mostly looking at the new methylation features in the data. Cool to be able to look at variation, phasing, and methylation all at the same time. #genomics #genetics
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When you are just trying to do your best and someone says to you. "If you were important here you would not have to teach so much". I am sorry, but teaching IS important. I like teaching, sharing knowledge, and Trainees DO matter. #teaching #science #11of18FallLecturesCompleted.
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Understanding genomics of autism is primary @TNTurnerlab. I received @PacBio SMRT grant to use HiFi seq to identify relevant genomic variation in a family with unsolved genomics. Relevant variant discovered. Check out #autism #genomics #longreads.
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On September 28, 2022 my first graduate student @EvinPadhi will defend his doctoral thesis! Join us in Connor Auditorium at 10 a.m. @WUSTLdbbs @WashUGenetics @TNTurnerLab #genomics #genetics #autism Please DM if you would like the zoom link.
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At #ASHG23 #ASHG2023 and all checked in. Stickers you say? Why, yes please! Glad to be here #genetics #genomics @GeneticsSociety
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Lots of exciting presentations today about different types of saturation mutagenesis / massively parallel reporter assays. Many genes being characterized by multiple labs around the world. Is anyone generating a lookup database for all these genes and labs studying them? #ASHG22.
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Today, second anniversary @TNTurnerLab. Growing, developing, and generating new research. Movin’ forward, finding our place and building collaborations with others willing to work with young progressive PIs. Proud of my team. 1/2.
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3 years . working on year 4 @TNTurnerLab!.
Today is the first day of the Turner Lab in the Department of Genetics at Washington University School of Medicine. I cannot wait to get started! #TNTurnerLab #genetics #genomics
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I am here at my poster PB3266. Do you have any individuals with 9p deletions and/or duplications? Please come see me and I would be delighted to talk about our work on 9p Minus Syndrome #Genetics #genomics @WashUGenetics @9p_minus #collaboration
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Our invited trainee session starting now (session 19, ballroom B) @MollyGasp @rovingscientist Matt Maurano @tycheleturner #ASHG19 #ASHG2019
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I am very honored to be listed in the 40 under 40 in "Chronicle of a field retold: Autism science in profile" via @Spectrum.
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Final day at #eshg2023. Great overall conference, honored to be a speaker, and fun to catch up with collaborators and friends both old and new!
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Today is the Five Year Anniversary of @TNTurnerLab @WashUGenetics where we focus on Precision Genomics. #Statistics! Remember #ILoveNumbers!. * 8 undergraduate students.* 5 rotation graduate students.* 1 graduate student graduated and now in postdoc.* 13 graduate student thesis
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Our @TNTurnerLab @WashUGenetics ACES manuscript is now out in Bioinformatics! Code available here and it now also runs in the cloud! #genetics #genomics #bioinformatics.
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When someone tells you about a scientific discovery that could transform human health and the only things that they talk about are Patents, Prizes and Papers. Reminder to all of us, myself included, to remember a major Priority is still People.
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Ready for the 2019 retreat @WashUGenetics, my first! Looking forward to the great talks and poster session #genetics #genomics
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Tune in at 5:45 p.m. EST tonight for @TNTurnerLab graduate student @EvinPadhi @GeneticsSociety talk on de novo noncoding variation in autism, Session 51. Proud PI as my first graduate student is presenting on this large-scale. Wish him best! #ASHG20.
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About to head to final sessions of last day #ASHG22! Some thoughts from this year's meeting:.1/.
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Jeffrey Ng presentation "Clustering of de novo noncoding variants in the genome in autism" right now at #ASHG23 #ASHG2023 @TNTurnerLab @WashUGenetics #Genetics #genomics #autism
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Gearing up @TNTurnerLab. Looking for postdocs, research technicians, bioinformaticians to join my lab for projects on noncoding variation, long-read sequencing, function. Email tychele@wustl.edu or DM #genomics #genetics #longreads #function #autism #9pminus #MultipleSclerosis
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Multiple opportunities to work in the #TNTurnerLab at Washington University School of Medicine in St. Louis, Missouri! Please see our website for details on current openings. @WashUGenetics #genomics #genetics #bioinformatics.
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Thursday we welcome my friend @JG_Underwood for @WashUGenetics weekly seminar! Jason is a brilliant, innovative, game-changing scientist who has been critical in development of techniques for understanding the biology of life. Please join us! #genomics #genetics @PacBio.
Join us for the Fall 2020 Seminar Series on Thursday, October 1 at noon. Speaker is @JG_Underwood, PhD, from @PacBio. #WashUGen
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Our @TNTurnerLab paper on coding and noncoding variants in EBF3 is now out in Human Genomics! #genomics #genetics #enhancers #autism #HADDS @WashUGenetics.
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Yay! Our @PacBio WGS data described in is now available on @NCBI SRA #genetics #genomics #longReads #neuronal @TNTurnerLab
New data generated in @TNTurnerLab on a cell line by @HillaryHeins and Juana Manuel. Loading of the @PacBio data into HiCanu … yes!!! Hoping we can get this into @NCBI SRA soon. Reads: 11,755,267.Bases: 230,618,386,614. #genomics #genetics.
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If you are looking to call de novo variants please check out Hare And Tortoise (HAT) The Hare workflow works with GPUs and the Tortoise workflow works with CPUs. H/T to @Jeffng29Ng in @TNTurnerLab @WashUGenetics . #genomics #genetics #HAT.
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Today, I stopped by the @GeneticsSociety stand and asked about the membership pins. Turns out I have been a member since 2007 (back in the undergrad days 😊) Received my 10+ year pin! #ASHG22
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Thank you to Dr. Heather Mefford @hcmefford for delivering an outstanding invited talk in our @WashUGenetics seminar series! Your presentation highlighted cutting-edge research and demonstrated impressive innovation in the field. The discussion was engaging and inspiring,
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Checked out the Chihuly Exhibition @ChihulyGG this weekend … it was amazing! A must see in Seattle
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This was an intriguing project that started out as a study focused on developing a faster de novo variant (DNV) caller and waded into some interesting biology. .1/10.
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Late for a date, but ya know sometimes the PI has to stay late to clean shared space when it’s their lab’s weekly duty and it didn’t get done. Benches wiped down, door wiped down. Special shoutout to the custodial team for helping me with sweeping/mopping the floors! You rock!
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We @TNTurnerLab are interested in noncoding regions of the genome. Long-read sequencing has enabled new reference genomes (e.g., the exemplar Vertebrate Genome Project). We want to use these new genomes to study noncoding elements across expansive species #genomics 1/4.
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TNTurnerLab Outing @ St. Louis Cardinals Baseball Game! Cardinals won, Yadier Molina broke a record, we made it on the BIG screen, and I even made sure to catch my work call at the game! @Cardinals #STLCards @WashUGenetics @TNTurnerLab
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4 years of examining missense variant clustering in NDD & cancer, our paper hopefully on bioRxiv soon. @TNTurnerLab ran #AlphaFold @RIS_Washu_IT to generate >4000 protein structures & deposited in #ModelArchive at Now online 🙂! @KarchinRachel @WU_IDDRC
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Thursday, we are delighted to welcome Dr. Keolu Fox @KeoluFox for @WashUGenetics weekly seminar! Dr. Fox is a dynamic speaker who will be presenting on "Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools" Please join us! #genomics #genetics.
Join us for the Fall 2020 Seminar Series on Thursday, September 24 at noon. Speaker is @KeoluFox, PhD, from @UCSanDiego. #WashUGen
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Just picked up my copy! Nice commentary in there by @lea_starita @JShendure @dougfowler42 Congratulations to the Cotterman award winners @pwhook from @FunctionalDNA lab and Taylor Mighell from @TheRealDrOLab #ashg18 #genetics #genomics.
If you are at #ASHG18 this week, be sure to pick up your copy of this year's Best of AJHG in your conference bag. If you can't make it to San Diego this year, don't worry! You can read it online, too! .
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First day at #eshg2023! First time in the U.K. and First time at ESHG. Thanks for the invite. Ready to go. Fun!
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Thank you for this amazing assembler! We have been very impressed using it for our @pacbio HiFi data. We look forward to trying out the new version as well.
HiCanu is published in @genomeresearch! Accurate assembly of segmental duplications, centromeres, and allelic variants from @PacBio HiFi reads w/ @sergeynurk @sergekoren @ArangRhie @mrvollger @glennis_logsdon @khmiga ->
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We welcome world-renowned human geneticist Dr. Aravinda Chakravarti @WashUGenetics March 25, 2021. His innovative work, "The Causes of Multifactorial Hirschsprung Disease," will be the presentation topic. Dr. Chakravarti was also my amazing graduate advisor. #genomics #genetics.
Join us for the Spring 2021 Seminar Series on Thursday, March 25 at noon. Speaker is Aravinda Chakravarti, PhD, from @nyugrossman @nyulangone. Here's the Zoom webinar link!: #WashUGen
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Last day training @BerkeleyLab Thanks especially to Len Pennacchio for the invitation and to @diane_dickel @AxelVisel @mannbran @evgenykvon @Malhar7 @Pribaikalochka @m_osterwalder @NIshorst and everyone else for the amazing discussions and collaborative work! #Genomics
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Enjoyable and gratifying week with incoming @WUSTLdbbs students participating in our Immersion Program on "Noncoding, regulatory regions in the human genome" Great to explore the noncoding genome together and looking forward to this new academic year! #teaching #genome #noncoding.
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Running @Google DeepVariant through new @nvidia Parabricks 4.1 on brand new @pacbio Revio data from a cell line we are characterizing in @TNTurnerLab on our @LambdaAPI Workstation with 2 NVIDIA RTX 6000 Ada GPUs is blazing fast. #genomics #genetics #gpu #longRead #letsgo.1/2.
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Happy #Thanksgiving !. A perspective piece I wrote for @_TheTransmitter is online now. It is a 6 minute read and provides insights into the application of long-read sequencing in several areas of #neuroscience. Hope you enjoy! #genomics #longReads .
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First image from @TNTurnerLab during #RNAscope training. Slightly lower resolution due Twitter upload. Imaging @wuccilab on new #confocal from @NIMHgov instrument grant to @JFitzpatrickWU. Colleague stated full image looked like from @NASAWebb.😊 #noncoding #collaboration
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“Germline mosaicism of a missense variant in KCNC2 in a multiplex family with autism and epilepsy characterized by long‐read sequencing” from @TNTurnerLab and our wonderful medical colleagues @WU_IDDRC #autism #genetics #genomics.
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Spending time with #family this weekend. This year's family #pumpkin painting/carving theme was pets/animals. Use your own creativity. Here is my addition to the family group #SonicTheHedgehog #loveFamily #weekends
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April 20th at 12 AM PDT @LabRoots talk goes live In the talk I discuss how we use @PacBio HiFi long-read sequencing @TNTurnerLab, especially for Precision Genomics in 9p minus syndrome #LRgenetics #genetics #genomics @WashUGenetics @GenomeInstitute.
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Thanks @GeneticsSociety for opportunity with late-breaking abstract, 10th anniversary of my 1st ASHG meeting as undergrad, Honored #ASHG17
Congrats to @tycheleturner for a great talk to close out a great meeting! #ASHG17.
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Our @TNTurnerLab paper "de novo variant calling identifies cancer mutation signatures in the 1000 Genomes Project" now published in Human Mutation We posted @biorxivpreprint in May 2021 and released code/call sets #genomics #genetics @WashUGenetics 1/5.
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Amplify the voices of 10 more women . let's keep it rolling! @MollyGasp @daniela_witten @tuuliel @KarchinRachel @meganamsu @PBSLab_Webb @PattiDickson @laurenmac_r @TaraMatise @RatnapriyaRinki @morris_lab @lab_lawson @nara_sobreira @MollahLab @Suz_Maloney @bethkarenmartin.
Amplify the voices of 10 more women. let's keep it rolling! @blueyedgenes @cecilejanssens @ellenleffler @tycheleturner @emo_davenport @mgymrek @hakyim @sargoshoe @michelebusby @ksamocha.
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Beyond thrilled to welcome @mike_schatz to our @WashUGenetics dept. seminar #PiDay2024. Prepare for an extraordinary journey through cutting-edge science in #genomics #genetics. And because no Pi Day is complete without actual pie, we have pie from Pint Size Bakery! See you soon!
Join @WashUGenetics today @ Noon CST in Connor Auditorium when Dr. Michael Schatz @mike_schatz, presents (in-person only) “Computing at scale with the NHGRI AnVIL”, hosted by Dr. Tychele Turner @tycheleturner .
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Visiting Mom and Dad. Went to Cruella in a nearly empty movie theater! Picture is from the previews. #familytime
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January 2024, our method HAT for calling de novo variants published now in Bioinformatics at This is @TNTurnerLab paper#8 #bioinformatics #denovo #genomics #genetics.
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Updated @TNTurnerLab preprint includes analysis of WGS from an additional 4216 trios, CPU-based version of code publicly available, and additional confirmation experiments #genomics #genetics #denovo.
New preprint out from the @TNTurnerLab @WashUGenetics.
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Today, I featured the final 50 of #50genomictools Writeup and highlights in 2018! #bioinformatics #genomics
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Someone recently insinuated that being called a "bitch" is a bad thing. 🤦♀️ PLEASE, that seems like a rite of passage in this field for a woman. However, I would prefer to give another choice, "assertive woman".
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Come work with me @TNTurnerLab and others @WU_IDDRC to help facilitate the next phase of a large gene database #genomics
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Did you attend @Genetics Society talk Session 51? Are you interested in working in our @TNTurnerLab @WashUGenetics on noncoding variation, long-read genomics, artificial intelligence, and other groundbreaking research? DM me and let's talk! #autism #genomics #genetics #ASHG20.
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I am looking for serious applicants who are interested in doing a postdoc in Human #Genetics in my lab. Looking for wet and/or dry lab postdocs. If you are interested, DM me.
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Journal Pre-Proof online now for @TNTurnerLab "From Karyotypes to Precision Genomics in 9p Deletion and Duplication Syndromes" Excited to share with others our collaborative work w/colleagues @WUSTL @WashUGenetics to understand #genomics of 9p dels & dups.
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Next week is the @AutismINSAR 2021 Virtual Meeting. My Tuesday talk “Identification and Characterization of Noncoding De Novo Variants in Autism” is under session “Molecular Genetics: ASD Genetics: New Data and New Insights” #autism #genetics #genomics @TNTurnerLab @WashUGenetics.
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Tomorrow is Rare Disease Day. Learn more about our WashU medical team and research project for 9p minus syndrome and regarding 9p information for families @PattiDickson @9p_minus @WashUGenetics @rarediseaseday #genomics #9pminus #RareDiseaseDay.
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Below are @TNTurnerLab presentations at #ASHG23 #ASHG2023. 11/3 3-5 pm Poster [Board No. PB4466].11/4 2:15-4:15 pm Poster [Board No. PB3266].11/4 2:15-4:15 pm Poster [Board No. PB4500].11/5 10:45-11 am Platform Talk [Conv Ctr/Room 207A/Level 2, Presenter 6]. #genetics #genomics.
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Throughout 2017 I'm going to highlight #50genomictools that have been useful to my past/present research #genomics #bioinformatics.
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Our session today on Personalized Medicine with co-chairs @SpirosDenaxas @tycheleturner and all the speakers #biodata22
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Thank you to @NICHD_NIH for funding our R03 grant! Enthusiastic to apply our computational methods to generate a comprehensive #nuclear & #mitochondrial #genome de novo variant callset for Gabriella Miller Kids First Pediatric Research Program! #genomics
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Today’s adventure with my Dad … golfing! Mom surprised us and made a steak dinner afterwards at home.😊
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Happy #ASHG22 week! To celebrate, @TNTurnerLab released HARE updated code, our GPU-based de novo variant workflow in HAT (. free HARE +free version @nvidia Parabricks = everyone runs GPU-accelerated version! #genetics #genomics.
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Thank you to @sahin_m for the invite and opportunity to present a talk at the Rosamund Stone Zander Translational Neuroscience Center @BostonChildrens. Awesome Center and Faculty! #genetics #genomics #neuroscience #autism #neurodevelopment #snowstorm
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This work in assessing the role of "De Novo Mutation in an Enhancer of EBF3 in simplex autism" will be presented in a platform talk by @EvinPadhi at the @GeneticsSociety virtual meeting in October 2020 #autism #genomics #genetics @TNTurnerLab Tweet 2/2.
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Excited to have posters up around the lab regarding our specific @TNTurnerLab research! #genomics #genetics #autism @WashUGenetics
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