Ashton C Trotman-Grant
@ATrotmanGrant
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Creative Discovery @EvoscaleAI Prev: Karyo Studios, @FiftyYears, @UofT (PhD Immunology). Co-founder, Notch Tx. Stay curious.
San Francisco, CA
Joined March 2019
The process of “spinning out” science from universities is broken. Why?👇🏾🧵
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Priscilla Chan and Mark Zuckerberg on Curing All Disease We sat down with Dr. Priscilla Chan and Mark Zuckerberg, co-founders of the Chan Zuckerberg Initiative, to discuss their ambitious plan to cure, prevent, and manage all disease by the end of the century. CZI’s Biohub aims
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ES will be joining forces with @Biohub to create the first large-scale scientific initiative combining frontier AI & frontier biology. Together, we're building world-class compute, AI research & state-of-the-art technologies to cure or prevent disease.
biohub.org
The large-scale scientific effort combines frontier AI with frontier biology to accelerate discovery and solve disease.
Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub. This is the first large scale scientific
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Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub. This is the first large scale scientific
biohub.org
The large-scale scientific effort combines frontier AI with frontier biology to accelerate discovery and solve disease.
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Biotechnology is about the predictable engineering of life, such that we can protect it and proliferate it through the Universe. Biotechnology ought to cure all complex diseases (so far, we have cured zero.) It ought to prevent infectious diseases, and remove needless suffering
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A scientist in 2040 doesn't hold a pipette. They explore the complete molecular atlas of an organoid on a computer screen, zooming in from regions of whole tissue to single proteins. A synthetic heart grows in front of them, the graphics on their screen rendered in real time from
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This specific mechanism actually seems novel, but for those unfamiliar with immunology literature: - Silmitasertib has already been shown to modulate MHC (specifically HLA-I) on tumors [1] - CK2 known to sit on the IFN > STAT1>IRF1>MHC axis [2] - CK2 inhibition known to
pmc.ncbi.nlm.nih.gov
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and gives rise to metastases in 50% of cases. The presence of an inflammatory phenotype is a well-known risk factor...
An exciting milestone for AI in science: Our C2S-Scale 27B foundation model, built with @Yale and based on Gemma, generated a novel hypothesis about cancer cellular behavior, which scientists experimentally validated in living cells. With more preclinical and clinical tests,
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The @AsimovPress podcast is coming soon. My first episode is on using AI to create new antibiotics with @delafuentelab. Here is the first ~3.5 minutes of an hour-long episode. Also, I'm looking for a video editor to help me out! Please DM if you're interested.
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Published today in @ScienceMagazine: a landmark study led by Microsoft scientists with partners, showing how AI-powered protein design could be misused—and presenting first-of-its-kind red teaming & mitigations to strengthen biosecurity in the age of AI.
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One of my favorite days of the year 5050 US Cohort 7 is kicked off and humming Now with more AI safety, and retro spaceship HQ 🚀
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we're turning @fiftyyears into an immersive deep tech theater company :-P
Founder's raison d'etre -- powerful talk by @joshsandtoes at the C7 5050 kick-off talking about the @noya_carbone experience
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Excited to share this work from my PhD! See our structure below of a computationally designed IL-21 mimic with anti-tumor efficacy in mice. A collaboration between the David Baker, Stephanie & Mike Dougan, Warren Leonard, and Chris Garcia labs.
Scientists have designed an interleukin-21 mimic with increased stability and capacity to induce more potent #antitumor activity than the native protein, which could inform improved #immunotherapies. @UWproteindesign Learn more in Science #Immunology: https://t.co/WR1foQx6Mq
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Am joining @fiftyyears in their program to help researchers build startups for safe and aligned AI. Don't Die is a mission for safe and aligned AI. Working alongside of @woj_zaremba, Jaan Tallinn, @eshear, @inkynumbers, @dileeplearning, and @RonnieChatterji.
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I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12 🔗
nature.com
Nature Medicine - In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong...
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Fifty Years has been cooking 🍳 a very cool event for those interested in translating their research!! Stanford, Berkeley, UW and Caltech, this is your chance :)
Startups are the best way to scale the impact of research. At 50Y, we've helped 100s of scientists go from lab bench to founding. Want to learn how deep tech companies get started and how to grow into a great founder? Join us at Stanford, Berkeley, UW, or Caltech 👇
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Startups are the best way to scale the impact of research. At 50Y, we've helped 100s of scientists go from lab bench to founding. Want to learn how deep tech companies get started and how to grow into a great founder? Join us at Stanford, Berkeley, UW, or Caltech 👇
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We talked to @ElliotHershberg (Partner @AmplifyPartners) about the challenges in life sciences technology. "There has been a general sentiment that you can make a huge amount of progress with new data and new technology in life sciences." "It actually turns out that it's really
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We're sponsoring the use of ESM3 and EMSC to help researchers engineer improved PETase enzymes in the @AlignBio 2025 Protein Engineering Tournament. Get started using ESMC to predict protein function and ESM3 to generate new enzymes here:
1/4 🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️ #AIforBiology #ClimateTech #ProteinEngineering
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