QComp: A QSAR-Based Imputation Framework for Drug Discovery #DrugDiscovery #QSAR https://t.co/BrvSyY50qd #JCIM Vol65 Issue15 #MachineLearning #DeepLearning

Light pollution is causing birds around the world to sing for longer each day, prolonging their vocalizations on average by 50 minutes, according to a new study in Science. Learn more: https://t.co/DneC4mTJf2

A new paper, in Nature Chemistry, proves that there are still tons of "basic" things to discover in biology. There is so much room at the bottom. TL;DR: Researchers discovered a new type of post-translational modification, called “oligophosphorylation.” Rather than being tagged

Our HIV-1 nuclear import study is now online in Nature Microbiology 📄 Read the paper: https://t.co/45CzNIx4CN 🎥 Watch the stunning movie of the virus in action: https://t.co/DmA5xl1VTV Huge congratulations! @OxfordStrubi @eBIC_Diamond

Antiviral Activity of Catechin against Dengue Virus Infection by Yi et al. 👉 https://t.co/rhvtdUysjd #antiviral #dengue #virus #research

We released the Open Molecules 2025 (OMol25) Dataset last week! 🚀🧪 OMol25 is a large (100M+) and diverse molecular DFT dataset for training machine learning models. It was a massive collaborative and interdisciplinary effort and I’m super proud of the whole team! 🙌 1/7

Understanding Conformation Importance in Data-Driven Property Prediction Models https://t.co/wxyXHns8K0 #JCIM Vol65 Issue7 #ChemicalInformation

A 'one-drug-fits-all' approach to mental health often doesn’t work, but hopes for drugs for ‘domains’ of psychiatric disorders took a blow with the discontinuation of J&J's aticaprant for depression with anhedonia. Read about paths forward in the May issue https://t.co/OQTsQAhjVT

Computational drug repurposing: approaches, evaluation of in silico resources and case studies https://t.co/yuKQ0U1Bj7 This new review from @REMEDi4ALL evaluates computational approaches to drug repurposing based on categorization of available resources into an online catalogue

Just now: @arcinstitute and @nvidia release Evo 2, the largest AI model for biology. It is fully open-source. Evo 2 can predict which mutations in a gene are likely to be pathogenic, or even design entire eukaryotic genomes. We covered it in @AsimovPress! Check it out 🔻

Choosing good DFT functionals is hard! There's a web of different forms & corrections, and it's often non-obvious how they stick together. Our guide for non-experts weaves its way through GGAs, mGGAs, hybrids, range-separated hybrids, double hybrids, & dispersion corrections:

Dijkstra’s algorithm doesn’t just tell you the fastest route to one destination. Instead, it gives you an ordered list of travel times from your current location to every other point that you might want to visit — a solution to what researchers call the single-source

Cell signaling is context specific, as this accordion metaphor illustrates. Here is an example from mapping the oncogenic PI3K signaling code with single-cell resolution: https://t.co/qDSkXFQx0I

Timescales in Cell Biology

We are happy to present our review article, just in time to celebrate World CRISPR Day: A review of virus host factor discovery using CRISPR screening | mBio

How do epithelial cells organize uniform polar orientation during long-range collective migration? I'm @EmmaLng2, and my research focus on collective cell behaviors. In this thread, I will take you through the concept of topology-guided polar ordering of collective cell migration

Key numbers in biology. 1/2

lol

The Nobel prize website has a pretty well made 1-pager on how Alphafold works

The 2024 Noble Prize in physics has been awarded to Cillian Murphy and Margot Robbie for the Barbenheimer effect. This phenomenon, involving the superposition of two very attractive people, allows physics to become interesting, a state which is otherwise spin-forbidden.