timisstuck
@timisstuck
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Executive Editor at Life Science Alliance: https://t.co/RCS3L4PRC9 Now with even less Musk: https://t.co/C7i7rnBOT0
New York, NY
Joined June 2008
I tried to cram a lot into this little editorial! Excited and grateful to be in this role, and (dare I say) optimistic for the future.
In this editorial, our new Executive Editor Tim Fessenden shares his vision for the journal. In the midst of systemic and concerning changes in biological and biomedical research, LSA strives to lower barriers to publication & meet authors where they are.
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Completely open-source and temperature stable LAMP method for pathogen detection! Expensive proprietary enzymes and mastermixes, begone! . Check out the paper/press release 👇.
Novel open-source diagnostic tool offers affordable, reliable pathogen detection for resource-limited settings. Read the article here and the press release here
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As a wonderful instructor in grad school informed me and my classmates: "You may not realize it, but you have all been inducted into the religious order of p < 0.05". Read the perspective here:.
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🚨 LSA institutes ban on p-values 🚨. (a joke). BUT the latest in the excellent series on Reproducibility at @JCellBiol argues for effect sizes (CI95 etc) to replace null-hypothesis testing: "Rejecting the no-effect hypothesis tells us about the experiment, not the biology"
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I love this question and the many thoughtful replies. Should be a Perspective-type review article!! .👀👀.
I’d love to hear biologists weigh in on the fundamental question: can you predict the impact of cell perturbations better by studying the natural variation in a population of healthy cells (more data), or by studying cells that have been perturbed genetically or chemically?.
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Congrats Ernst! As always, really impressive work coming out of UChicago.
Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicago.
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Sometimes you see a paper that is a doppelgänger of your past proposal. So satisfying!. I never thought I'd see one paper combine such detailed tumor immunology WITH reference to the wonderful and robust literature on how immune cells move. Congrats to Ting Zhou and coauthors!
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Much needed break from AI and stuff 😌.
If you're tired of AI and stuff. we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons:
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"Our protocols empower laboratories and public health institutions worldwide to take control of their diagnostic capabilities, especially during outbreaks.” .-co-first author Martin Matl. Press release here:
eurekalert.org
Researchers have developed an open-source molecular diagnostic assay for pathogen detection, successfully tested for COVID-19. The innovative RT-LAMP method is heat-stable, uses only non-proprietary...
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Authors in Vienna and Ghana created the first temperature-stable RT-LAMP pathogen detection kit that uses 100% non-proprietary reagents! Huge win for #OpenSource and #FrugalScience efforts to democratize disease outbreak responses!!. 🥳
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RT @DelgoffeLab: If you are an @AACR member and are part of the Cancer Immunology (CIMM) Working Group, consider voting for me for Chair i….
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RT @Align_Bio: 1/4.🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the ty….
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Very important work benchmarking @illumina EPIC methylome platforms, with resources on mitigating readout differences!.
Thrilled to share this #epigenetics work comparing #Illumina #EPIC v1 and v2. Authors find significant readout differences in #EpigeneticClocks, #celltype, lifestyle #biomarkers between versions, and offer recommendations to mitigate version effects
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yikes!.
MitoTracker transfers from astrocytes to neurons independently of mitochondria
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👀👀👀.
It's Friday it's summer, let's have some fun. Drop in the comments the meanest things a reviewer has ever said to you (bonus if it's on a manuscript you think is good & that you ended up publishing in a different journal). I'll start with the masterpiece below.
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Meanwhile over here in our universe we have (had?) the NIH Directors Award… and MIRA…
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Important history!!.
Explore the history of cancer immunotherapy over the last 100+ years, from early observations to modern breakthroughs, and discover its transformative ability in the fight against cancer, in The History of Cancer Immunotherapy: #Immunotherapy.
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I always repost tertiary lymphoid structures 🙌.
Grateful for being a part of this story!.
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