Subhojit Roy, MD, PhD
@Roy_Lab_Thinks
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Science. Music. Sometimes funny. https://t.co/S6hf1G42O1
La Jolla, CA
Joined May 2011
Massive 10+ year effort in lab spearheaded by @leonardoaparrar and Kayal (secret account 🤔). Unreal cover by @EmmaVIDALL that says it all.
2023's final issue is out! https://t.co/ImgPc6z4Dp Cover story is from @Roy_Lab_Thinks's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here https://t.co/8SSr68cHRb
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"In a story of theft and security lapses, “Fedora Man” is a gentler counterpoint — a teenager who believes art, style and a good mystery belong to ordinary life" https://t.co/NLOG0nJGUK
apnews.com
Fifteen-year-old Pedro Elias Garzon Delvaux has become an internet sensation after an Associated Press photo captured him outside the Louvre on the day of a crown jewels heist.
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Last ditch experiments before starting new journey!
Signs of new life amidst carnage. Postdoc Leo @leonardoaparrar (left, Brent on right) is heading East to U Maryland @UMmedschool as an Asst Professor with the Institute for Neuroscience Discovery ( https://t.co/xwpmoJeDvR)
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Transformative medical discoveries from utterly basic science is not an exception. Its the rule. https://t.co/h2Ut80vQkU
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Check out our new resource paper @CellStemCell, where we present a brain organoid atlas of human neurodevelopmental disorders. Surprising was that nearly all patients had abnormal organoids. The challenge was aligning defects to clinical. https://t.co/0YtGTd4Dwb
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Scientists are obsessed with intelligence. But you don't need an astronomical IQ to design a simple experiment that will slash through the darkness. In fact high IQ people often lack the simple-minded clarity needed for designing good experiments.
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...but as G. Costanza would say: is this "Significant Shrinkage"?
Neurons transmit signals through synaptic vesicle release, but the nanoscale dynamics of this process have been unclear. In a new Science study, researchers report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ and propose a unified
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Incredible by @OdedRechavi ... an AI thingy-bop that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why:
qedscience.com
Critical Thinking AI for constructive criticism and science evaluation
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"Even short, regular check-ins can make a difference. Time spent helping students to solve problems, or simply asking how a project is going, will pay dividends. It also saves time later by catching small problems before they become big ones" https://t.co/Orps361XFf
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🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @DrNeuroChic
https://t.co/gAStfXlsTX...
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Thank you John Sayer @johnasayer for sharing your experience of fee-free #OA publishing in @J_Cell_Sci via our #ReadAndPublish agreement with @Uni_Newcastle @uonlib Read John’s paper https://t.co/CW0Jx0vvRD Is your institution participating? https://t.co/WpJcxTtBmG
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4 Nobels for UC in 2025, 75 since 1934, 1/4 winning women have ties to a UC. https://t.co/YP9F50VEKv
universityofcalifornia.edu
These discoveries span decades and disciplines, but they all have one important thing in common: They’ve all relied on competitive funding from the federal government.
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I'm giving a talk at this SFN sponsored symposium in Singapore, students in the area consider submitting abstract - deadline coming up Oct 14:
sfn.sg
The Society for Neuroscience, Singapore Chapter (SfN.SG) is happy to announce that registration and abstract submission for the Annual Symposium are now open! The symposium will
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Honestly if I was a non human primate, I'm not sure I'd appreciate a human just sitting and staring at me all day. #justsa
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I went to #Chile 25 years ago - when Internet wasn't a thing - and this is all I needed to know. It went just fine.
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“She took a character on the page and gave her such truth, precision and warmth that Hyacinth became part of the national conversation; instantly recognisable, endlessly quotable, and loved around the world" https://t.co/HmAO4HD57P
theguardian.com
The actor was best known for her role as the pretentious housewife Hyacinth Bucket, and for the series Hetty Wainthropp Investigates
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"So far, just the headline findings have been released. Scientists say the full study needs to be published and assessed by independent experts to properly assess what has been achieved" Umm...yes. https://t.co/J9f1SK0kbE
bbc.com
Families are elated by news of the first treatment for Huntington's disease - but when and how will the NHS fund it?
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"But the foibles and embellishments that make up his story have no place in modern cricket - rubber snakes, mobile phones, firecrackers et al - all of which would today attract ICC demerit points, rather than foster sense of enjoying the stage together"
espncricinfo.com
The game mourns the loss of an iconic figure who epitomised cricket in the pre-technology era
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Slowly getting ready to finally submit this paper. Would love feedback. In essence, we mapped and tracked EV transfer of a-synuclein single molecules from neurons to neurons. @Roy_Lab_Thinks @christlet
https://t.co/gEuS0SGl5P
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Target engagement + "increased myelination (P = 0.0137) and improved MSEL developmental outcomes (P = 0.0171). Thus, interim results suggest that gene therapy with MYR-101 is well tolerated and shows early effects in Canavan's Disease" AAVs in oligos!
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