Sunish Radhakrishnan
@sunishk
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Figuring out developmental signalling in bacteria @IISERPune
United
Joined December 2009
In this article we describe a mechanism that regulates the progression of DNA replication when bacterial cells encounter nutrient poor conditions. Excellent work by @Surbhi_Yadav_ supported by @arnabshau @ChackoFeby @India_Alliance @IISERPune
cell.com
Surbhi et al. report that a conserved AAA+ ATPase, IncA, whose production is enhanced in nutrient-poor conditions, is required to inhibit DNA replication progression by delocalizing the β-sliding...
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Out now at @PLOSBiology we evaluate the potential for antibiotic efflux and cell wall biogenesis as targets for reversing drug resistance and preventing its de novo evolution in Escherichia coli. Link below: https://t.co/oeQ71wxFTJ
journals.plos.org
Intrinsic resistance pathways in E. coli can be exploited to enhance antibiotic sensitivity and limit resistance evolution. This study shows that genetic inhibition of efflux pumps and cell envelope...
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DRILS-ARUMDA/TIFR joint #postdoctoral position Exciting opportunity to contribute to biomedical research aligned with national missions Complex phenotypes, malnutrition, NCDs, aging Please RT #academic #DataScience #multiomics #metabolomics
@IndiaBioscience @biopatrika
📢 We are #hiring! Join #ARUMDA Team @TIFRH_buzz as a Postdoctoral Fellow focused on #metabolomics & advanced data analysis. 🗓️ Apply by Nov 25, 2025 🔗 https://t.co/prTQYxx64J
@UllasKolthur @Mahen_Son
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Preprint 📢 Why is recombination at centromeres detrimental for chromosomal segregation during meiosis? Read our preprint to know more about what we found in fission yeast. Work led by @Shugosen
https://t.co/LWfIM5ZphC
biorxiv.org
Centromere-proximal crossovers (C-COs) are repressed during meiosis across all species. Moreover, aberrant C-COs are strongly correlated with meiotic aneuploidy such as in Down syndrome. Despite...
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Want to know ways of choosing partner to reduce stress! Bacteria have mastered perfect metabolic pairing- here is one of our work in @PLOSGenetics : https://t.co/mKcSoGh2YG
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How do cells keep their #actin “highways” stable?🚦 Our new @PLOSGenetics paper reveals surprising teamwork (and backup plans!) between tropomyosin isoforms in #yeast. #imaging This work was brilliantly led by @anubhav_dhar and funded by @India_Alliance, @ANRFIndia @iiscbangalore
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🎉🍾Excited to share our #Asgardarchaea #odin #cytoskeleton study published in @embojournal Dual FtsZ proteins in Odinarchaeon form distinct filaments—shedding light on tubulin/FtsZ evolution. Brilliantly led by @Jayantikri23
https://t.co/nhj4xfNM1A
Thrilled to share our lab's first evolutionary cytoskeleton study! We uncover two distinct FtsZ paralogs in Odinarchaeota—OdinFtsZ1 forms curved filaments, while OdinFtsZ2 assembles into spiral rings. A glimpse into tubulin evolution! #Eukaryogenesis #AsgardArchaea #cytoskeleton
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Our new paper is out! 1/16 How does an organ rebuild its shape after injury? It's not just about making new cells, but aligning them in the right direction — like bricks shaping a structure. https://t.co/oZ4zLCOVCm
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https://t.co/NTFq5BJeY1 Latest from the lab. @ICGEB @ICGEBNewDelhi @DBTIndia Excellent collaboration with Vinay @ccmb_csir @aiims_newdelhi and @Lab_AmitSinghal Thanks to support from @India_Alliance
pnas.org
Transcriptional adaptation drives the host responses to Mycobacterium tuberculosis (Mtb) infection. However, Mtb alters host RNA splicing to quench...
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"The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation" Now published @NatureMicrobiol 🥳! https://t.co/CuyIhKmQxj
I'm excited to share the newest preprint of the lab... the structure of the complete extracellular flagellum, our most favourite bacterial nanomachine! https://t.co/fR8EhAdntY A result of a very productive collaboration with @BergeronLab and @BeebyLab !
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New study shows how bacteria evolved powered-up propellers https://t.co/eKXKHbLDvl ... https://t.co/i3shDpAY3e
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📢 Get ready! The India Yeast Meeting 2025 (IYM 2025), the 13th international conference on fungal biology, is coming to Bangalore! at Indian Institute of Science (IISc), Bengaluru from Dec 3rd-6th, 2025. stay tuned for updates @IYM_2025_IISc #IYM2025 #FungalBiology #yeast
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Inauguration of ARUMDA National Analytical Facility for Nutrition & Metabolism Research by Dr. A.K. Mohanty (DAE-Secretary). Dignitaries: Dr. Anil Kakodkar (former DAE-Secretary), Prof. Chengalur (Director-TIFR), Prof. M. Krishnamurthy (Center-Director-TIFRH).
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latest from us "Regulation of the essential peptidoglycan hydrolytic complex FtsEX-PcsB during Streptococcus pneumoniae cell division" https://t.co/AZvJZPDzl8
biorxiv.org
In the human commensal Gram-positive bacterial pathogen Streptococcus pneumoniae, the essential extracellular cell-division-associated peptidoglycan (PG) hydrolase PcsB interacts directly with the...
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Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhav_dhar in collab with @Sudiya14 @deepak_iisc #actin
https://t.co/GTTRUF8dGC
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Please RT. Post-doc opportunity alert! 💥 closing 5th May.. Come join our team ( https://t.co/7PN1tJGp4H) at Imperial, London, working on bacterial secretion systems. The position is funded by the Wellcome Trust. For more details and to apply please see https://t.co/MSEJe6UWMW
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Now published @CurrentBiology. Happy to share latest work from the lab led by @ashamjos and @Adhikashreni1, describing replisome speed variation in Caulobacter! https://t.co/hiTTH0EB59
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And here it is, the completed BASEL collection finally published as early access in @PLOSBiology - see the thread for more details. 🤗🧬🎣
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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Now published! Congrats to @WeeBoon5 again! Read the final version at https://t.co/JCXvOvFGHr!
nature.com
Nature Communications - The Tol-Pal complex is important for multiple cellular processes in Gram-negative bacteria, but its molecular functions remain unclear. Here, Tan & Chng provide...
Super excited to share our latest work on the bacterial Tol-Pal complex by the brilliant @WeeBoon5! We can (finally) confidently assign the true function of Tol-Pal in maintaining OM lipid homeostasis, independent of its role in cell division! Here's how Wee Boon did it 👇 1/7
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Now published our work on sensitizing MRSA to beta-lactams in @nchembio, very nice collaboration with Mobashery and Chang labs at @NotreDame. Extra bonus with the cover of the journal. hope you enjoy
nature.com
Nature Chemical Biology is an interdisciplinary journal that publishes the most innovative and important research advances at the interface of chemistry and ...
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