Shu-Sin Chng
@Figlegend
Followers
2K
Following
10K
Media
198
Statuses
6K
Assoc Professor @NUSingapore @ChemNUS Membrane/lipid biochemist. Educator who teaches chemistry in biology. Advocate for students in Faculty of Science.🇸🇬📯📯
Singapore
Joined April 2012
Really excited to be sharing our newest work on the bacterial Tol-Pal complex! The amazing @yeowjiang solved cryo-EM structures of the TolQRA complex in 2 rotary states, aiding us to come up with a model for force transduction across the cell envelope! #SGBUG @SCELSE_SG @ChemNUS
Structural insights into the force-transducing mechanism of a motor-stator complex important for bacterial outer membrane lipid ... https://t.co/DVs24OZ84v
#biorxiv_biophys
1
8
49
New #mBio study finds that long O-antigen #polysaccharides are a double-edged sword. While critical for protection against external host assaults, their transport and assembly onto the surface comes at the cost of compromising the outer membrane barrier. https://t.co/nKFlfByUE0
0
4
20
Using multiple cryo-EM structures, we revealed how the periplasmic chaperone SurA dynamically changes its conformation to deliver substrates to the BAM complex. Miyazaki et al., 2025, bioRxiv https://t.co/g7zkwqiwhz
1
3
18
細菌に必須の膜タンパク質 MurJ と、それを阻害するファージペプチドとの構造解析・第２弾！ ファージ由来の SglPP7 と LysM は、同じ Lipid II フリッパーゼ MurJ を標的にするが、結合様式は異なる。収斂進化のようだ。 Hosoda et al., bioRxiv (2025) https://t.co/IcDlImMS2F
Structural basis for MurJ inhibition by phage lysis protein SglPP7 suggesting convergence https://t.co/xezKJn771E
#biorxiv_molbio
0
4
6
New in #mLife: @hyq2015, @JilongQ & @DrTotsika explore how both overly stiff and overly fluid membranes impair biofilm growth in E. coli—revealing a “Goldilocks” fluidity zone. @wileymicrobio 👉 https://t.co/cJwALhWbMc
0
5
4
Our MurJ/LysM paper has been published in Science Advances. Kohga et al., Sci. Adv. (2025). This study elucidates, through cryo-electron microscopy, the mechanism by which the small bacteriophage-derived protein LysM inhibits the lipid II flippase MurJ. https://t.co/u5ZibBF0kA
塚崎研では、現在、発表前の論文（投稿中）を3つbioRxivにアーカイブしています。 bioRxivは生物系研究を査読前に公開するサイトです。 最先端の研究にご興味あればぜひ！ https://t.co/OihJ1sTGPm
https://t.co/6l91wVG6fS
https://t.co/kKfdpvh14p #構造生命科学研究室 #塚崎研 #NAISTバイオ
0
13
28
We are back for #SGBUG for Oct, with Shaun Tan from Benson Chen's grp at @ASTARsg, and Jason Chen from Chris Sham's grp at @IDTRP_NUSMed, sharing about genetic manipulation in gut commensals, and glycoengineering in S. pneumoniae, respectively!
0
0
1
If you are attending the Great Wall Symposium happening this week in Sicily, do check out @WeiChuenPoh's poster on very interesting TolB variants he has found, which might help us think deeper about the function of the bacterial Tol-Pal complex! Poster 93!!
0
0
3
...by carrying out protein biochemical, cell biological, and live cell fluorescence imaging experiments. Associated structural analysis of the proteins by cryo-electron microscopy will be undertaken via collaboration with other workers. 3/3
0
0
0
Join the group of Prof Ben Berks to study the bacterial Type 9 Secretion System. Build on our recent work (Nature (2018) 564:77, Nat Microbiol (2021) 6:221, Nat Microbiol (2024) 9:1089, bioRxiv (2025) https://t.co/3CpciS6BXz)... 2/3
biorxiv.org
Bacteria of the phylum Bacteroidota are major human commensals and pathogens in addition to being abundant members of the wider biosphere. Bacteroidota move by gliding and they export proteins using...
1
0
0
Helping Ben Berks @UniofOxford with an ad. Postdoc Research Associate in the Molecular Analysis of Bacterial Protein Transport https://t.co/wakpZwUVpC 1/3
1
2
2
Right now is the best chance the scientific community has ever had to end the artificial scarcity of academic journals. Check out my new op-ed urging @NIH @NIHDirector_Jay to disallow taxpayer dollars towards journal publication fees — something both publishers and scientists
14
58
202
Be our IMB colleague! Join us for cool science! OPEN FACULTY POSITION, INSTITUTE OF MOLECULAR BIOLOGY, ACADEMIA SINICA, TAIWAN
nature.com
One tenure-track faculty position is open for a qualified individual to establish an active research program at the IMB.
0
4
7
Oxidative protein folding is a crucial process for #mycobacteria. Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria. https://t.co/cE62DrmWi3
1
7
20
Our study where we develop EvoBind2: Design of linear and cyclic peptide binders from protein sequence information is now published! https://t.co/WPjPaWmTuT
3
41
215
#Newpaper Bacterial cell walls are polymers made of sugar backbones cross-linked with amino acid peptides. Recent work from Manjula Reddy's lab led by @shambhavi_garde highlights how the identity of the amino acid most proximal to the sugar backbone is crucial for bacteria. 1/2
2
13
53
A collaborative paper with Manjula Reddy’s lab @ccmb_csir led by @shambhavi_garde is now online @PNASNews. @aakash0308 from our lab @IISERPune contributed with some LC-MS experiments reported in this study. https://t.co/7KncNMal4y
pnas.org
Peptidoglycan (PG), a defining feature of the bacterial cell envelope, is crucial for cell integrity and morphology. PG is a macromolecular mesh co...
4
6
89
And now Yujie Li from the lab of @Yuanqiao1002 @NTUsg talking about her work studying peptidoglycan fragments in serum! #SGBUG
0
1
3
#SGBUG is back for July 2025 with Dylan Alexander from the group of Chris Sham @IDTRP_NUSMed sharing about S. pneumoniae capsule biosynthesis!
1
1
7
The lipidome is deeper than we think - enzymes are strict molecular rulers but they have some flexibility. Check out 2 new endogenous lipids found in E. coli. Awesome collaboration with @Figlegend and Jungwook Kim
jbc.org
Biological membranes, which comprise proteins, lipids, and glycans, serve as essential gatekeepers protecting cells from the external environment. In bacteria, phospholipids are a major class of...
1
4
11
Excited to share our new paper out in @NatureComms today! 🎉 Proud to have contributed to this work — check it out here:
nature.com
Nature Communications - This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows...
3
6
37