Jiameng (Linda) Sun
@sun_jiameng
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PhD candidate @WashUDBBS : liver metabolism, circadian clock
Joined February 2023
Gut Microbes published a review by Brian DeBosch, MD, PhD, from @IUMedSchool and @sun_jiameng from @WashUdbbs that highlights how #reciprocal regulation connects the gut #microbiome, the #liver, and their intrinsic #circadian clocks. Read more here: https://t.co/RarrpfMJMv
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Congratulations to Jeong-ah Kim and Siqi Chen in Emery Bresnick's and Sunduz Keles' groups on discovering a splicing factor kinase requirement for oncogenic ATPase DDX41 function: https://t.co/r9eKLVYJXJ
@UWMadison @UWCarbone
nature.com
Nature Communications - Although DDX41 genetic variation occurs in myelodysplastic syndrome and acute myeloid leukemia, the pathogenic mechanisms remained unclear. Here, the authors found DDX41...
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This work is inspired by the findings from Chaix et al. @SatchinPanda Cell Reports (2021) and Cell Metabolism (2019), where they characterized sex-dependent and circadian clock-independent functions of time-restricted feeding.
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Happy to share that another part of my thesis work studying circadian gene Per1 in liver metabolism is online in @MolMetab today! In this work, we characterized how Per1 mediates time-restricted feeding effects in different sexes. https://t.co/LlfmfYUn2y
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GATA2 decommissioning of enhancers: A mechanism to constrain inflammatory signaling: Cell Reports
cell.com
Jung et al. discovered that the critical regulator of blood cell development, GATA2, suppresses the activity of transcriptional enhancers that activate genes encoding key regulators of inflammatory...
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Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed
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Now online! Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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Here is our protocol featuring our publication on hepatocyte Per1-mediated fasting regulation!
Online now: Protocol to evaluate fasting metabolism and its relationship to the core circadian clock in mice https://t.co/f1lr0SyYRO
#protocol #starprotocols #cellpress
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This is the most important paper in the circadian field in over a decade. A completely new clock component that is evolutionarily conserved. @Eric_E_Zhang @susanksgolden @ @SRBR_Outreach
https://t.co/Gh8fUhDeP7
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Thrill to share that I will be giving a talk at #ENDO2025 @TheEndoSociety! See you all in San Francisco 🌁
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Heard a great talk from Dr. Masayuki Tsukasaki this Thursday in the field of osteoimmunology. Especially impressed by how his team figured out the beautiful mechanism on how bone defenses cancer invasion. His talk inspired me in multiple ways and really want to write this down.🦴
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New! Online now: Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring https://t.co/Liv6F1B0yd
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A blood-based biomarker panel for non-invasive diagnosis of metabolic dysfunction-associated steatohepatitis https://t.co/gmxwTw2OxZ
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Really want to thank the enormous help received from our collaborators. This paper wouldn’t become possible without their guidance.
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Happy to share that my first first-author research paper is now available at @CellReports. We studied how the canonical circadian gene Per1 regulates liver fasting metabolism through Fgf21 and Pdk4, and their relationship to the core circadian network. https://t.co/ksLpnAhr5F
cell.com
In this paper, Sun et al. show that a core circadian gene, Period 1, is uniquely upregulated during fasting in liver. Mice lacking hepatocyte Per1 fail to oxidize glucose and fatty acid properly...
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Great people, great science, great place, can’t ask for more! @KernLipid
@KernLipid 2024, that's a wrap! Such a fantastic meeting and community. Look at us all doing our best phospholipids impressions! See you In 2026, when we will be focused on brain lipids 🧠!!
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Congratulations to Linda Sun, UW-Madison/WBCRI undergrad alumnus, for her outstanding accomplishments and multiple awards in the Wash U PhD program in the Division of Biology and Biomedical Sciences. @emerybresnick @UWCarbone @uwsmph @sun_jiameng
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Congrats Marlie and the team!!! Check out this cool paper on NatureComms!
🧬 Exciting new study out in @NatureComms! We identify cell-type-specific responses in pancreatic islets to stress, shedding light on diabetes progression. It is #OpenAccess for all to download for free! #DiabetesResearch @WUSTLmed @WUDeptMedicine
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