Ashley St. John Lab
@StJohnLab
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St. John lab @DukeNUS studies immune responses to human pathogens and develops novel vaccination strategies. We love mast cells. Tweets by Ashley.
Joined February 2018
Did you know that the fetal immune system can protect from congenital infection before birth? -Proud to share our study identifying protective functions of #microglia, contrasting the harmful early influence of #monocytes and primitive macrophages to #zika virus infection.
Now online! Differential contributions of fetal mononuclear phagocytes to Zika virus neuroinvasion versus neuroprotection during congenital infection
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A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. Read more in @ScienceTM: https://t.co/HMAZlYMhaL
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A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. Read more in @ScienceTM: https://t.co/HMAZlYMhaL
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A new analysis of a cohort in Nepal links the waning of vaccine immunity against Japanese encephalitis virus to elevated chymase levels and a higher risk of severe #dengue infection. @StJohnLab @dukenus @smlhtr_
https://t.co/iuI3V1aiu5
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Dengue is rising. In Nepal, studying >500 #dengue patients, we found that waning immunity to Japanese encephalitis virus (#JEV) was associated with worsened dengue severity, which has implications for #vaccine campaign planning. First au🙌: @smlhtr_
https://t.co/tdR7MMF0gg
science.org
Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal.
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Thank YOU for inviting me to a fabulous meeting!
A big thank you to Ashley St John @StJohnLab from Duke-NUS Medical School for kicking off our 2025 Vic/Tas Branch Meeting at the beautiful Melbourne Zoo, with an engaging talk on how the fetal immune system controls congenital viral infections! 🐅🐘🌿
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Excited to share our new #OpenAccess review: "Maternal IgE Influence on Fetal and Infant Health" led by Jozef. We discuss how maternal #IgE shapes fetal immunity and the shift to intrinsic early-life IgE production, with implications for #allergy onset. 👉 https://t.co/0hyAOLdRQB
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Little break from talks to visit Knossos Palace… finally spending time with @Zhijuan_JExpMed not on zoom!
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https://t.co/uCddNwmhuC So excited to share our work on placental changes across gestation. Activation of immune cells types in term placentas even before labor and a reduction in toleragenic cells. Congrats @BunmiOlaloye et al. @YalePediatrics @YaleMed
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Happy to share our preprint assessing the body composition, in a South Asian population. Adiposity and lean muscle indices that associate with cardiometabolic risk factors and inflammatory mediators in a South Asian population https://t.co/QCca12N7ql
@chandi2012 @dumni
medrxiv.org
Background Cardiovascular diseases (CVD) are the leading cause of death in South Asia with visceral adiposity and sarcopenic obesity emerging as critical risk factors. Methods We conducted a cross-...
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Very proud moment 😊- the 1st paper of our lab has just been published: https://t.co/h8q5tLHF5M This tour-de-force work was bravely headed by the fantastic @MaryemRadhouani, showing that #Eosinophils develop #InnateMemory upon skin #infection with implications for lung #allergy
science.org
Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.
I'm excited to share that my first-author PhD paper is now published in @SciImmunology! We showed that skin infection with S. aureus imprints bone marrow eosinophils to fuel lung allergy. 🔗link to the study: https://t.co/WoRNMp6mrX Let’s dive in 🧵1/9
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Awesome Power of Genetic Screening! Very honored to be part of this wonderful discovery—MFSD6 is an entry receptor for Enterovirus D68!
🚨 New paper in Nature! MFSD6 is an entry receptor for enterovirus D68. Proud to have contributed to this work, led by brilliant co-first authors Lauren Varanese & Lily Xu. Gratitude to Jan Carette, Wah Chiu, and co-authors including Carolyn Bertozzi. 👉
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📢 Delighted to introduce the 2025 Associate Editorial Board: @Casanova_Acebes @CNIOStopCancer, @DGateLab @ARC_Neuro, Elisa Oricchio @EPFL_en, Tim O’Sullivan @UCLA, Ashley St. John @StJohnLab @DukeNUS, and Tuoqi Wu @UTSWMedCenter. Welcome! 👉 https://t.co/7ATvFp3nHD
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Save the date for #HCVFlavi2025, a joint Asia-Pacific meeting to be held October 13-16, 2025 in Singapore @dukenus! More info to come!
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Assoc Prof Ashley St John and her team have found that foetuses can better fight infections in the womb than we thought. Read more about it at https://t.co/dPXQEvAeQa 📸: Chinmay Mantri #DukeNUS #Research #InfectiousDiseases #MaternalHealth @StJohnLab
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I finally decided to open a Blue Sky account for our lab and will try to share the same lab news and shared papers on both sites for now. Find us at @stjohnlab.bsky.social
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Our third year fellow Dr. Farouk Farouk, mentored by Dr. Amy Pham, was recognized for one of the Neo Abstracts of Excellence by the ILPQC.
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This special issue is a labor of love that's been over a year in the making. Many thanks to the authors who contributed and those living with Long Covid who sounded the alarm in the first place.
In this week's new special issue on #LongCovid, a collection of articles explores the latest frontiers in disease mechanisms, sex differences, emerging therapeutics, and other facets of this enigmatic condition. https://t.co/hBcL1F0Gtf
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Our data showed varied functions of myeloid cells in early life while identifying therapeutic targets. We are grateful to our collaborators @FGinhoux @HongyanWang9 @lai9uan @CJM_lab @Abhay_R_ and their teams for all their support, ideas, tools, and enthusiasm over the years!
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