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Stephanie Lo Profile
Stephanie Lo

@stephlo_lo

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Associate Professor @UniofBath and Senior Staff Scientist for Global Pneumococcal Sequencing (GPS) project @pneumowatch @sangerinstitute

Cambridge, England
Joined November 2015
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@stephlo_lo
Stephanie Lo
1 year
@UniofBath
University of Bath
1 year
We speak to Dr Stephanie Lo @stephlo_lo from the Department of Life Sciences, about her life-changing research into vaccine implementation and antimicrobial usage. https://t.co/0UwsVSovgQ @UniofBathSci
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@MicrobioSoc
Microbiology Society
6 days
Microbial Genomics is looking to appoint a Deputy Editor-in-Chief, who will help develop the editorial strategy and new content for the journal. Applications close on 1 November, more information about the role can be found here:
microbiologysociety.org
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@pneumowatch
GlobalPneumoSeq
12 days
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@pneumowatch
GlobalPneumoSeq
18 days
🦠🧪🧬 Excited to share that our GPS Pipeline, the portable and scalable genomic pipeline for Streptococcus pneumoniae surveillance, is now published in @NatureComms 🔗 https://t.co/zMpJWPTMEl #GPS_project
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nature.com
Nature Communications - The GPS Pipeline enables accessible and scalable genomic surveillance of Streptococcus pneumoniae. It performs quality control and in silico typing of sequencing reads with...
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@pneumowatch
GlobalPneumoSeq
21 days
[New pre-print🚨] When a single genotype (pbp) confer resistance to multiple antibiotics (penicillin and cephalosporins), how do we make sense of genetic changes and their impact on AMR? A new concept - AMR cartography is invented by @Quackscience https://t.co/8UWQNdHgUr
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@pneumowatch
GlobalPneumoSeq
25 days
[🚨 New paper] The first nationwide, longitudinal WGS analysis of Streptococcus pneumoniae in Taiwan (2006–2022). 1,343 isolates from 27 hospitals, we track serotype, AMR, and genomic lineage before and after PCV13. #GPS_project #PCV13_impact #Taiwan https://t.co/PcRsmAmkov
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microbiologyresearch.org
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@Bacterioskeptic
David W. Cleary
1 month
New paper out in Pneumonia. More data from the carriage study in Southampton, UK looking at pneumococci in pre-PCV13 era versus early- and late-PCV13 periods (I also snuck in some bits on other bacteria ... just for a bit of variety) https://t.co/prjdIDU8pc
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pneumonia.biomedcentral.com
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@cellhostmicrobe
Cell Host & Microbe
1 month
Promoter variation in Streptococcus: S. pneumoniae promoters contain repetitive nucleotides, driving strand slippage & promoter mutations. This drives population-level heterogeneity in gene expression, offering evolutionary strategy to maximize fitness https://t.co/qdojFlpogn
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cell.com
Barton et al. identify Streptococcus pneumoniae promoters containing repetitive nucleotide sequences that promote DNA strand slippage and accumulation of promoter sequence mutations. This drives...
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@stephlo_lo
Stephanie Lo
1 month
A great collaboration with Dr Dan Neill and his team in @dundeeuni and others in @ucl @StJudeResearch @unibern @uniofliverpool @UCT_news @uwanews @UniofBath @MilnerCentre @sangerinstitute @pneumowatch
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@stephlo_lo
Stephanie Lo
1 month
However, this promoter variant does not thrive on its own and is usually co-occurence of the wild-type promoter without "A", showing heterogeneous gene expression during single infections provides population benefits
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@stephlo_lo
Stephanie Lo
1 month
This tiny mutation—found not only mouse colonization models but also clinical isolates from the #GPS_project—enhance S. pneumoniae colonization reducing mucus trapping.
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@stephlo_lo
Stephanie Lo
1 month
[New paper alert🚨] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬 https://t.co/Sy0fqIPm7S
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cell.com
Barton et al. identify Streptococcus pneumoniae promoters containing repetitive nucleotide sequences that promote DNA strand slippage and accumulation of promoter sequence mutations. This drives...
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@stephlo_lo
Stephanie Lo
3 months
Our team is hiring an ambitious senior bioinformatician to look at bacterial capsules . This position will closely collaborate with @emblebi @StephenBentley5 @johnlees6 @stephlo_lo Closing date: 20 July 2025 https://t.co/pujNp7xiKg
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@ChrispinChaguza
Chrispin Chaguza
4 months
The Rosch Lab is hiring a Senior Scientist-Host Microbe Interactions in Memphis, Tennessee. The lab studies the interactions between pathogenic bacteria and their hosts. Review all of the job details and apply today!
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@stephlo_lo
Stephanie Lo
4 months
It’s my great pleasure to present the Global Pneumoocccal Sequencing project at #LISSSD25 I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science. #GPS_project
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@pneumowatch
GlobalPneumoSeq
4 months
Dr Dorota Jamrozy presents a well-powered GWAS to identify genetic features associated with invasive #GBS disease as compared with carriage at #LISSSD25 Thanks to the >20,000 GBS genomes in the #JUNO_project @sangerinstitute
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@pneumowatch
GlobalPneumoSeq
4 months
Over half a million of pneumococcal disease in children reported in China annually Our paper showed 1) 94% serotypes covered by PCV13 2) 99.8% isolates resistant to ≥1 antibiotics Routine PCV use in children will ↘️ pneumococcal disease and AMR https://t.co/bvVOvtshNW
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microbiologyresearch.org
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@stephlo_lo
Stephanie Lo
4 months
Good morning Brisbane! What a nice view to prepare my very first talk at #LISSSD25 ! Looking forward to meeting people at the conference. #GPS_project #pneumococci #Genomics
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@Katie_M_Webb
Katie Webb
4 months
☑️ Attended my first Europneumo. ☑️ Presented a poster at a conference for the first time. ☑️ Had a great time 😁 Loved being able to share what I've been working on over the past 6 months about the global patterns of serotype 4.
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