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John Lees Profile
John Lees

@johnlees6

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Following
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280

Pathogen informatics and modelling https://t.co/2Qg0pvaFg3 (Research group leader at EMBL-EBI - https://t.co/lJdwj0idt0)

Joined December 2009
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@embl
EMBL
1 year
Have you ever thought of doing a sabbatical at EMBL? It’s a great opportunity for scientific exchange and growth, and for learning advanced technologies and top-notch science! Three scientists shared their experiences on their research visits at EMBL. πŸ‘‡ https://t.co/2n6B6bfSQ0
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@johnlees6
John Lees
1 year
If you're a a master's student studying at a French university interested in these we're a possible host group -- send me an email to discuss
@emblebi
EMBL-EBI
1 year
Are you a student in France studying computer science, statistics, or bioinformatics? @FranceintheUK has opened a new round of internships hosted at EMBL-EBI. Find out more and apply. https://t.co/o9QdzfUKyn
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@johnlees6
John Lees
1 year
A mere six years after its first release, SKA is now published https://t.co/vtJGt98ged
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@ZaminIqbal
Zamin Iqbal
1 year
This is exactly the kind of thing we wanted to happen!
@TimoSaratto
Timo Saratto (Moilanen)
1 year
A cool upcoming feature: When you upload a sample to Solu Platform, we’ll search all public NCBI samples for related genomes. This is built on the awesome AllTheBacteria database by Martin Hunt, Leandro Lima, @shenwei356, @johnlees6 & @ZaminIqbal
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@RoliRoberts
Roli Roberts
1 year
This neat paper about rapid evolution of bacterial transformation rate by @eprocha @labXC & co takes some of its inspiration from an earlier @PLOSBiology paper by Nick Croucher & @ChristoPhraser:
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journals.plos.org
Modelling and high-resolution genomic data demonstrate the evolutionary significance of an ongoing arms race between bacterial uptake of environmental DNA ("transformation") and horizontal DNA...
@PLOSBiology
PLOS Biology
1 year
Why do #bacterial species' #TransformationRates vary so dramatically? @epcrocha @labXC &co show that #Legionella & #Acinetobacter transformation rates evolve by sudden changes, likely caused by conflicts between #MGEs and the host bacterium #PLOSBiology https://t.co/odHj02Kjws
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@ZaminIqbal
Zamin Iqbal
1 year
Daria Frolova's paper in plasmid relatedness now out in MGen! She uses rearrangement distances & shared seq content to build a relatedness network of plasmids, identifies hubs which are likely transposons, and then clusters related plasmids. https://t.co/fG0GCYqKZO @MicrobioSoc
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microbiologyresearch.org
@ZaminIqbal
Zamin Iqbal
2 years
First paper from my student Daria Frolova's PhD now on biorxiv: https://t.co/Ex2tbOujgG The key question: plasmids change structurally ~as fast as they mutate, so how can we decide whether 2 plasmids are "the same plasmid" for epi purposes? 1/n
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@jim_elevator
Jim Shaw
1 year
Happy to announce that our (me and @YunWilliamYu) metagenome profiler sylph ( https://t.co/WGX3W1yOjT) is now published in @NatureBiotech! 1/5
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github.com
ultrafast taxonomic profiling and genome querying for metagenomic samples by abundance-corrected minhash. - bluenote-1577/sylph
@NatureBiotech
Nature Biotechnology
1 year
Rapid species-level metagenome profiling and containment estimation with sylph https://t.co/rgG2K0Li2N
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@johnlees6
John Lees
1 year
Extension to ska 'skalo' -- using local assembly to recover indels and MNPs where split k-mers mismatch https://t.co/I4tilmrq3U We hope to integrate this into the main ska package in future too
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biorxiv.org
Insertions and deletions (indels) are important contributors to the genetic diversity and evolution of pathogens like Mycobacterium tuberculosis . However, accurately identifying them from genomic...
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@CamilleMrcht
Camille Marchet @[email protected]
1 year
I'm looking for a know fusion signature in a graph that contains annotated human transcripts (from Refseq) and samples, including prone to fusion (human carcinoma samples).
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@johnlees6
John Lees
1 year
There is still time to register for our SMBE satellite meeting on pangenomes and transmission in Tokyo (until 31st October) See our website for more details, and now a provisional schedule too! https://t.co/HnKRbshoVD
@johnlees6
John Lees
2 years
We are happy to have been selected by SMBE to host a satellite meeting on Pathogen Pangenome Evolution Between and Within their Hosts: https://t.co/HnKRbshoVD We are expecting the meeting to be in Tokyo on 26-28th November 2024, save the date!
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@johnlees6
John Lees
1 year
Also now old Celebrimbor is a big name in rings of power s2 maybe our backronym will finally land
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@johnlees6
John Lees
1 year
Now published in bioinformatics, CELEBRIMBOR 'pangenomes from metagenomes' https://t.co/L7FL5fekfe I think reviewer comments helped make it better, so worth another look (at fig 1 particularly!)
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academic.oup.com
AbstractMotivation. Metagenome-Assembled Genomes (MAGs) or Single-cell Amplified Genomes (SAGs) are often incomplete, with sequences missing due to errors
@johnlees6
John Lees
2 years
Sam has then wrapped it all up in a nice snakemake pipeline CELEBRIMBOR (Core ELEment Bias Removal In Metagenome Binned ORthologs) which lets you go from MAGs to pangenome https://t.co/c3BZprY94E
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@johnlees6
John Lees
2 years
Sam has then wrapped it all up in a nice snakemake pipeline CELEBRIMBOR (Core ELEment Bias Removal In Metagenome Binned ORthologs) which lets you go from MAGs to pangenome https://t.co/c3BZprY94E
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@EMBLEvents
EMBL Events
1 year
πŸ“’ Only a week left to submit your abstract for #EMBLInfectionBiology 🦠 The event is a platform for late-stage postdoctoral scientists in infection biology to connect with the leading European institutions in the field. It is fully virtual for the ease of access πŸ’» Discuss
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@johnlees6
John Lees
1 year
A reminder that abstract submission for the SMBE satellite meeting on pathogen pangenomes and transmission closes soon (8th September, a short extension). See: https://t.co/HnKRbshoVD
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@johnlees6
John Lees
1 year
I have written up some new notes in the intermediate programming course on parallel programming, which are available here: https://t.co/SIdrMS8Rhn The main intro and advanced examples are in rust, but I've also added two independent sections covering python and R.
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@sheppard_lab
Sheppard Lab
1 year
🌞🌞🌞Job alert ‼️ We have not one but two positions available with me in @IneosOxford @OxfordBiology. More details here: https://t.co/nAW2DFaszm If you're interested, get in touch. Please share/RT #AMR
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ineosoxford.ox.ac.uk
Join our cross-disciplinary team dedicated to finding solutions against AMR
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@johnlees6
John Lees
1 year
Josie Bryant (@Josie_M_B) and I have a 3yr joint postdoc project at Sanger & EBI (ESPOD) Topic: Developing new bioinformatic and modelling approaches for exciting new longitudinal microbiome datasets Project details: https://t.co/MY9SaO8x33 To apply:
ebi.ac.uk
The ESPOD fellowship builds on the collaborative relationship between EMBL-EBI and the Wellcome Sanger Institute, offering projects that combine experimental (wet-lab) and computational (dry-lab)...
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@aaron_weimann
Aaron Weimann πŸ‡ΊπŸ‡¦
1 year
Today in @ScienceMagazine, we report how a bacteria has evolved into a major human pathogen over the last 200 years. Read on, this is going to be an adventurous ride 1/n!
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science.org
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF)....
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