Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10)

Our study "Individualized VDJ recombination predisposes the available Ig sequence space" is now published in Genome Research 🥳 https://t.co/tRKIQK7Uh7 Congrats @rlyhighvariance et al.!

1/Excited to share my first author publication where we create split-engineered base editors (seBEs). Here, we place base editors under the control of a small-molecule to regulate the timing of genome editing and decrease off-target effects. To achieve it:

Or if you know of other resources/books on the topic… Many thanks in advance :)

Aside from lamenting time and mental resources wasted when I forgot them, I need examples -possibly life-sciences related- to liven up the talk and convince them that choosing the right positive/negative controls is not magic.

I just volunteered to tell 1st year PhD students of the importance of controls in a scientist’s life. Question for scientists on twitter: can you tell me of egregious cases where the lack of a single control changed completely the story and doomed a published paper forever?

Hopefully, one step closer to the clinic… It was exciting working on it: methylation, fragmentomics, and all. Thanks @benbfly and all others! Just a teaser: the correlation of methylation and tumour fraction (healthy controls are the blue bubbles). https://t.co/cpke43mo9q

If you enjoy #RNA biology, #RNAediting, and all sort of RNA modifications (#m6A, etc.), join us next week for the Final EPITRAN Conference. Just a few hours every day, Mon to Wed. The registration is free and the discussions engaging… https://t.co/h0DxY5nVrB

Accepted manuscript strongly suggesting that apparent SARS-CoV-2 reads that appear to be integrated in the human genome, are in fact an artefact of library preparation. https://t.co/UzR8QyBAMv

One of the most inspiring, as a person and as a scientist. A huge loss indeed. I will miss him

Do you want to explore basic research but also clinical practice? The IRCM's Master's degree in cellular and molecular medicine (MCM) is for you! https://t.co/YYtFpy2qZT

This is going to be useful! Thanks!

Final days to apply for a PhD in my lab. The science is interesting and the lab is welcoming. Of course you will also need to deal with the whole ugly Firenze thing on the side...

There is an important message here for today’s students. Techniques don’t matter. Questions do. Listing a set of techniques is silly because they will all be out of date in 10 years. But questions drive science forward.

can you imagine having been awarded a highly competitive grant to carry out a project you've been dreaming of doing for 10 years on a major global pathogen that still kills hundreds of thousands every year. and then halfway through -- #UKRIcuts #ODAcuts #GCRF #gcrfcuts 1/n

don’t joke about that… there goes our plasticware supply…

this is my project for the weekend…

special bonus for cell biologists: HEK293 genomic profile. Note how all CNVs are NOT clonal. Filippo, the bioinformatician, politely asked how biologists can use these t̶h̶i̶n̶g̶s̶ cells. A very good point… https://t.co/z5D4MLFL8K

By the way, for all #nanopore aficionados, our work on detection of Copy Number Alterations from #liquidbiopsy is out. No amplification, cell-free DNA goes straight to the flow cells (just add adaptors) [ https://t.co/z5D4MLFL8K]

Interested in targeting cancer through RNA editing? We have an opening for a PhD student in the #MSCA #ITN ROPES project. Contact me if interested. Deadline 16/04. Call and forms are at https://t.co/KOwAle7tLV (sorry, english part starts at page 15…) Please spread the word