Daniel Müller-Komorowska
@scidanm
Followers
383
Following
3K
Media
134
Statuses
1K
Neuroscientist in Okinawa, Japan @OISTedu. I use simulators to study brain disorders.
Japan
Joined May 2017
New preprint! We used simulation-based inference to predict compensatory potential of parameters given different causes of hyperexcitability. Check it out and drop me an email if you have questions/comments.
biorxiv.org
The activity of healthy neuronal networks is tightly regulated, and a shift towards hyperexcitability can cause various problems, such as epilepsies, memory deficits, and motor disorders. Numerous...
0
1
4
How can we train biophysical neuron models on data or tasks? We built Jaxley, a differentiable, GPU-based biophysics simulator, which makes this possible even when models have thousands of parameters! Led by @deismic_, collab with @CellTypist @ppjgoncalves
biorxiv.org
Biophysiscal neuron models provide insights into cellular mechanisms underlying neural computations. However, a central challenge has been the question of how to identify the parameters of detailed...
2
42
143
The lab's first paper, "Probing multiplexed basal dendritic computations using two-photon 3D holographic uncaging," is now online at CellReports ( https://t.co/t2jWbgp3hd). Congrats to @ShulanX and @Somit_sam on an outstanding and exquisite effort 👏. @PurdueBME @Research_Purdue
cell.com
Xiao et al. use 3D two-photon holography, dynamic clamp, pharmacology, and modeling to unravel multibranch dendritic integration in layer 5 pyramidal neurons under quiescent and in vivo-like states....
9
13
52
Our @eLife paper on artefactual Ca2+ waves following calcium indicator expression is highlighted in neuroscience magazine @_TheTransmitter. Really nice talking with @avaskham and seeing the perspectives from @Sheffield_Lab, @DanielDombeck & @LoogerL
thetransmitter.org
The technique, which measures calcium currents as a proxy for neuronal firing, sometimes reports unusual and potentially misleading waves of activity in the hippocampus.
0
15
67
"Angels of Victory" Moschun, a town just northwest of Kyiv. The local community established an improvised memorial site in this location of old dugouts and trenches from 2022. During the Battle of Kyiv, Moschun was the only place where elite Russian forces managed to cross the
102
1K
7K
Ukraine cannot fight evil with empty hands
ft.com
The trapped US funds are the difference between life and death for many of us
134
474
2K
Our newest preprint ist out. First one from my time in Japan. About inhibitory connections between parvalbumin interneurons and synchronous oscillatory network states.
biorxiv.org
Synchronous activity of neuronal networks is found in many brain areas and correlates with cognition and behavior. Gamma synchrony is particularly strong in the dentate gyrus, which is thought to...
0
1
13
I love this cover so much! @Norambr did such an amazing job (both in designing it and in supporting me throughout my PhD project journey). So please enjoy these cute mice exploring the path connecting the medial septum circuit to the VTA 🐭
4
3
28
A septal-ventral tegmental area circuit drives exploratory behavior My PhD work has been published in @NeuroCellPress and I couldn’t be happier! A thread 🧵(1/n) https://t.co/pPyzlcmlIm
10
48
185
When I was a kid, I was a very optimistic one. Always interested in military history, I read many books and articles about WW2 and wondered at the insane casualties of that war. I used to think these meat assaults would be impossible now, in the 21st century, with its internet,
Inside the battle for Avdiivka: Ukrainians trying to hold on in the face of massive (and very costly) Russian assaults. @CNN @cnni #Ukraine️ #Russia with @JosephAtaman @TarasovaMarkina
175
1K
8K
Really happy to announce that the editorial we wrote with @TTchumatchenko and Jeanette Hellgren Kotaleski is out! The special issue on computational neuroscience they edited is full of incredibly interesting contributions (all open access!). Link here: https://t.co/KeZC7nUbb9
1
11
39
Great summary here from @_Silver_Black_ of his #NeurIPS2023 paper - if you're in comp neuro and use gradient descent to train networks with separate E and I units, this will be really useful to you! (PS - This was from @_Silver_Black_ 's undergrad project in the lab!)
1/ Want to train🧠like RNNs with separate inhibitory and excitatory units with similar performance as standard RNNs? Come visit poster #430 in Session 1 (Tuesday 10:45am) at #NeurIPS2023 We show that spectral properties matter more than sign constraints:
1
5
34
Must-read thread on the supposed "slow-down" in EV sales, which is really shorthand for "not actually slowing down, but incumbent car manufacturers being out-competed by new entrants".
Lots of headlines written about how EV demand is faltering. Is it? Global EV sales are on pace for a record year. Heading for around 14 million sold, up 36%. https://t.co/toIkyQQpsZ
14
96
236
COUNTRY ANALYSIS: #Japan's GX #decarbonisation strategy fails to put #renewables at its core; its focus on "clean coal" tech at home & overseas inconsistent w 1.5˚C pathways. Without a rapid #coal phase-out, Japan will be seen as a laggard. "Insufficient" https://t.co/8TZeV5yHzY
2
10
16
I just saw Ukrainian air defense working against Russian. It sounds like fireworks. It is the second night of attacks. Yesterday, about 66 drones were intercepted over Kyiv. The night is just starting. Let’s see how it goes. (pics are from Reuters) 1/
18
274
2K
⚡️Russia launches record number of drones into Ukraine on eve of Holodomor Memorial Day. Russia launched a record number of drones into Ukraine over the course of six hours on the eve of Holodomor Memorial Day on Nov. 25.
27
254
786
preprint Alert📢 Time to talk about the🐘 in the room of genetically encoded Calcium indicators (GECIs). These indicators are widely used to report activity in the brain and an invaluable tool, but the expression of these GECIs can change activity. 🧵1/7 https://t.co/bEuBa0V6Vh
1
14
38
These are the rules of the game of civilization: the first priority is to guarantee the existence of the human race and their comfortable life. Everything else is secondary." From The Three-Body Problem, a novel by Liu Cixin.
0
0
1
Right now, if you want to visit your grandfather, you can get there on my personal jet and cross the ocean in a dozen hours or so. But without oil, you'd have to tumble in a sailboat for more than a month…
1
0
0
"We can have no seabirds, but we can't be without oil. Can you imagine life without oil? Your last birthday, I gave you that lovely Ferrari and promised you that you could drive it after you turn 15. But without oil, it would be a pile of junk metal and you would never drive it.
Lots of reactions to the #IEA World Energy Outlook 2023 finding that fossil fuels reach a peak based on today’s policy settings (the ���STEPS’ scenario). Worth digging in a bit as to what a peak actually means (and doesn’t). Thread.
1
0
0