Joh Schöneberg Lab
@schoeneberglab
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4D Cell Biology!
San Diego, CA
Joined July 2020
4D mitochondrial network assumes distinct and predictive phenotypes through human lung and intestinal epithelial development! @GCMcMahon et al: #latticelightsheet #microscopy of #mitochondria in #organoids from #stemcells to study #devbio - #4dcellbio. 📄: https://t.co/YMSKZIjuYu
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Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → axons & myelin across mouse olfactory bulbs (WT vs NPC1).
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New piece in Journal of Cell Science on the origin and evolution of mitochondrial inner membrane structure and composition #lipidtime @Co_Biologists
https://t.co/oF5mg7iG79
journals.biologists.com
Summary: An examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialization of...
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Check out our new paper in @NatureBiotech sharing our latest kinase activity reporters! Led by former postdoc Michelle Frei, these reporters are based on HaloTag rather than an FP, for far-red imaging and superresolution!
nature.com
Nature Biotechnology - Far-red kinase biosensors are applied to image kinase signaling networks at super resolution.
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Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data! @ecarkfeld @ZacharyWang379 @hhako2 📄: https://t.co/CAMlRtri1o 💻: https://t.co/pjTm3BQ6nN
#simulation #latticelightsheet #llsm #microscopy #cellbiology #mitochondria #microtubules
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🚨!! JOB OPENING !!🚨 Join us as a postdoc to investigate how 4D mitochondrial dynamics determine cell fate! You can reach out to us at https://t.co/Nvj5xDgGOx or use this web form: https://t.co/TgQOxSL5Fs Looking forward to hearing from you! Pls RT friends🌞
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!! JOB OPENING !! Join us to develop deep learning-based image processing pipelines for petabytes of 4D lattice light-sheet microscopy data! https://t.co/Qv34TK6QOG Pls RT friends 🌞
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🚨 JOB CALL!!! 🚨 If you’re interested in neuronal cell biology, come and work with us to use custom imaging and omics tools to study organelle contact sites in neurons. Please RT friends‼️ Open calls for a @wellcometrust funded Post doc and RA position listed below…
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Super excited to introduce MitoSpace: The first mitochondrial phenotypic atlas created using self-supervised deep learning! @Parth_LFC @ZacharyWang379 @AroraMehul1 @hhako2
https://t.co/mElmHWQuGz
#MachineLearning #deeplearning #ai #drugdiscovery #microscopy #mitochondria
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Like to grow brains? Our lab is hiring a #postdoc in #dementia drug discovery using #4D #mitochondria dynamics in Brain #organoids 🧠📷! Please spread the word and apply.🎉
jobs.sciencecareers.org
Gather 4D data on how tau protein aggregates influence mitochondrial dynamics in dementia brain organoids and how novel drugs can reverse the damage.
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Congratulations to Susan Taylor, PhD, Distinguished Professor of Pharmacology, Chemistry and Biochemistry, for being selected as one of the 1000 Best Female Scientists in the World by https://t.co/fGmBwWFaFI!
@UCSDChemBiochem
https://t.co/5TFSH21VBM
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Really hyped to share this preprint of some of my postdoctoral work with @OWeinerLab @virtual_embryo @BustamanteLab in which we set out to investigate whether membrane tension propagation in cells https://t.co/6L8ZzusTky Here is a summary of our findings 🧵
biorxiv.org
Membrane tension is thought to be a long-range integrator of cell physiology. This role necessitates effective tension transmission across the cell. However, the field remains strongly divided as to...
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Like to grow brains? Our lab is hiring a #postdoc in #4D #mitochondria dynamics in Brain #organoids 🧠🔬🎉! Please spread the word and apply here:
docs.google.com
Welcome! We are the 4D CELL Biology Lab at UC San Diego. Would you like to gather the first 4D datasets of how tau protein aggregates influence mitochondrial dynamics in dementia brain organoids?...
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Please RT! I am looking to hire a #postdoc to develop graph-based models and methods to analyze cutting-edge 4D lattice light-sheet imaging of 🧠organoids collected in @schoeneberglab. Join our multi-disciplinary team! Apply: https://t.co/2XkXDXGFTl
#postdocposition #hiring
A $1.3M Keck Foundation grant will help @UCSanDiego researchers (@gmishne, @FleurMFerguson, Johannes Schoeneberg) learn more about misfolded tau proteins and their role in frontotemporal dementias incl #Alzheimers. https://t.co/FPX3rsM99f
@HDSIUCSD @UCSDMedSchool @UCSDChemistry
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Open Faculty Position: Assistant Professor- Pharmacology/Chemistry & Biochemistry The focus of this search is in the broad areas of Metabolism, Mitochondria, and Human Diseases. Apply here: https://t.co/avzvJH7inP
@SilvioGutkind @UCSDChemBiochem @UCSDHealthSci @UCSanDiego
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We would like to thank: Brenda Andrews, @jaebyumchang, @EM_STP, Dong Li, Emma Lundberg, Julia Mahamid, @SulianaManley, Musa Mhlanga, Akihiko Nakano, Johannes Schoeneberg, @davidvanvalen, Ting ‘C.-ting’ Wu and @AssafZaritsky for sharing their expert opinion!
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My first last author paper, and we got to polka dot cells! Thank you: @HFarsibaf @jennyqzou and @gdanuser1. https://t.co/VN2Sa64IJX
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This looks fantastic! Thank you for creating this. Cellular Harmonics for the Morphology-invariant Analysis of Molecular Organization at the Cell Surface
biorxiv.org
The spatiotemporal organization of membrane-associated molecules is central to the regulation of the vast signaling network that control cellular functions. Powerful new microscopy techniques enable...
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Great to meet @MatthewAkamatsu again today at Find Your Inner Modeler! https://t.co/FQ2pKHzcUs
#CellBiology #computationalmodeling
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