Weiner Lab
@OWeinerLab
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Molecular logic of complex cell behaviors. Orion Weiner's lab @UCSF. Account run by lab members. #CellMigration #CellPolarity #Mechanics #OptoTools
San Francisco, CA
Joined February 2021
We made it to the cover 🤩 !.
Our August cover image shows the localization of the WAVE complex (solid colors) and cell edge (dotted lines) of a migrating neutrophil-like HL-60 cell over time. From Pipathsouk, @OWeinerLab et al. (. Read JCB August Issue:
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RT @SVibha1: 👇Take a look at my new @preLights post! ."Rac and Rho team up! Long-distance mechanochemical coordination for migration". High….
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RT @BurkhardtLab: Henry De Belly's elegant work on front-rear coupling during cell migration is out in bioRxiv! Being a part of this work….
biorxiv.org
In migrating cells, the GTPase Rac organizes a protrusive front, whereas Rho organizes a contractile back. How these GTPases are appropriately positioned at the opposite poles of a migrating cell is...
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RT @Henry_de_belly: Hello everyone, excited to share our preprint: ----.Everyday, cells like this crawl through you….
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✨Check out the lab's latest bioRxiv ✨. We explore how cells use long-range mechanochemical feedback to establish and maintain polarity during cell migration!.
Hello everyone, excited to share our preprint: ----.Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate? Lets chat!
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✨Pre-print time!✨. Excited to share Kirstin Meyer’s latest work showing how Yap charge patterning mediates transcriptional co-condensate formation! Fantastic collab with @BoHuangLab, Kiersten Ruff, & @ShuLab2010 🤩.
biorxiv.org
Transcription factor dynamics are used to selectively engage gene regulatory programs. Biomolecular condensates have emerged as an attractive signaling substrate in this process, but the underlying...
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RT @Henry_de_belly: Happy to share the review Orion & I wrote for Current Opinion in Cell Biology ! @OWeinerLab. ht….
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RT @Dev_Cell: Online now: Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming
cell.com
Strickland et al. find that human neutrophils organize pulsatile, self-extinguishing waves of leukotriene B4 to ensure robust homeostatic recruitment. Self-extinguishing waves are dependent on the...
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We are thrilled to see Evelyn's paper on neutrophil swarming out in @Dev_Cell!! Congrats to all authors on this beautiful story! 🎉. Check out the 🎆 thread below ⤵️.
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✨Pre-print alert!! ✨. Check out Muziyue’s incredible thesis work ➡️ “The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation”.
Super excited to share my thesis work! . doi: We found how cells manage to build the extremely flat and thin membrane protrusions with the WAVE complex, that organizes into a linear polymer-like structure at the tips of lamellipodia.
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RT @QinNi09: We @SXS_biophysics wrote an insight article on the brilliant work by @tlngy, @strickland_ev, and @OWeinerLab! Combining a clas….
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RT @BenjaminYWiner: Our paper on PM abundance as a regulator for myeloid function is out at SI   I would like to th….
science.org
Plasma membrane abundance controls myeloid cell phagocytosis, migration, and in vivo responses against fungal pathogens.
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RT @sneha_arao: ‼️ Abstract deadline for BACS 2024 is this Friday April 12 ‼️. We highly encourage trainees at *all levels* to submit an ab….
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RT @sneha_arao: 🎉 Super excited to announce that registration is now open for the 2024 Bay Area Cytoskeleton Symposium on May 13 at UC Berk….
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RT @Henry_de_belly: So hyped to see this great story by @DengkeMa lab being finally out!! This paper is full of fascinating data and I high….
science.org
Early-life heat exposure produces long-lasting benefits on longevity in the nematode C. elegans.
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RT @cell_club: Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin | Science Advances https://t.co/….
science.org
Early-life heat exposure produces long-lasting benefits on longevity in the nematode C. elegans.
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RT @Henry_de_belly: My dear friend/collaborator Shannon is starting her lab at Stanford in a couple of months and she is looking to hire a….
biophysics-jobs.careerwebsite.com
A new
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Excited to share our paper on YAP dynamics and cell fate control! We reveal a concentration-dependent and temporal communication code for YAP that enables cells to choose between different downstream programs. Check it out! .
nature.com
Nature Communications - The transcriptional regulator YAP controls cellular decisions such as proliferation, differentiation, and pluripotency. Here, the authors show a concentration-dependent and...
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We are spinning in circles with excitement to see @JasonPTown fabulous work out @PLOSBiology ⤵️
.@JasonPTown & @OWeinerLab use spatially-defined #optogenetic control of a leading edge organizer to explore how #neutrophil-like cells balance “decisiveness” (needed to polarize in one direction) with flexibility (to respond to new cues) #PLOSBiology
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