The self driving multi-scale microscope from @Daetwyler_St is now on BioRxiV: https://t.co/RClR6BEmbz Here some immune - cancer cell interactions. The whole Zebrafish is imaged as well during this time lapse acquisition.

1/ Excited to share our new paper with @SihanSean @utswcancer @CRI_UTSW and Michael Lawrence @MGH_RI, now online @CD_AACR. Led by Shreoshi Pal Choudhuri, we found that ecDNAs with MYC paralogs drive acquired cross-resistance in small cell lung cancer #SCLC https://t.co/MraxEM6PKb

That's a wrap for the u-track 3D paper! Very grateful to all my co-author @legant_lab , @jennyqzou , @kD3AN, @tadastic , @ErikWelf, A. David, D. Gerlich, @RetoPaul, @EricBetzig and the precious guidance from @gdanuser1 :).

Out now! @HFarsibaf, @MegDrisc, @DanuserLab and colleagues propose a framework to assess the spatial scales of molecular organization at the cell surface in a cell-morphology invariant manner. https://t.co/rb6kojKSi5 👉 https://t.co/A69JUwnF9U

Excited to finally see this work out in @JCellBiol !!! Check it out if you're interested in: ✅ #zebrafish cancer models ✅ quantitative in vivo imaging assays ✅plasticity in Ewing Sarcoma 1/n

How sensitive is the analysis to the cell morphology? ZERO!! We simulated polka dot patterns to validate that the framework introduces the spatial scale signature in a shape-invariant mode. 6/6

Using this basis set, we parameterized the molecular signal pattern and computed the energy density spectra to define the spatial scale signature of a given pattern. 5/6

We introduced “Cellular harmonics”, hierarchical basis functions customized for each cell morphology by applying the Laplace-Beltrami operator on the 3D cell surface. 4/6

Powerful light microscopy enables 3D visualization of cell signaling. 3/6

Signal distribution on cells matters: from uniform to highly polarized patterns. 2/6

The organization of molecules on the cell membrane is crucial for regulating cell functions. Here we introduce a new pipeline for analyzing the molecular patterns in a shape-agnostic mode: https://t.co/Ruw17ZfiWB @MegDrisc @gdanuser1 @jennyqzou #CellularHarmonics,#uSignal3D 1/6

Woo hoo! Excited to finally share a big chunk of my postdoc work with this (updated) preprint: In vivo profiling of site-specific human cancer cell states in zebrafish https://t.co/LB0vrG3apJ Wanna hear more? Let's roll👇

And the bleb saga continues. @MuthrNaturzSon has worked on this for quite a while, and I am glad it is out now. Also happy to see 3D microscopy and 3D shape analysis leveraged in this work. Congrats to all involved!