Robert Ietswaart
@robertietswaart
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Co-Founder & CSO of Cellforma | Gene Regulation - Machine Learning - Cell Therapy
Joined July 2018
Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle https://t.co/sPoFmZu5Uk Published @MolecularCell Big thanks to fellow co-first authors @BrendanSmalec Albert Xu @stephenfloor mentor @fiddle +team!
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It was my great honor to write this @RNASociety #Spotlight article featuring @robertietswaart ! Anyone interested in quantitative biology, mathematical modeling, and a path to entrepreneurship should definitely check this out! The interview with Robert was such a pleasure. It
The RNA Society has kindly featured me in their Spotlight series. https://t.co/dWRBFTHi14 Get to know about my scientific vision on using gene regulation, RNA biology and AI/ML to build a virtual cell, as well as… 1/3
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@aaronlavelmoye @CarlaKimLab Thank you to the @RNASociety , in particular dr. @Guoming_Gao, dr. Jennifer Porat, and Prof. @DLKPhD for writing, editing and coordinating the spotlight. 3/3
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my past and recent RNA biology research; the inception of Cellforma with co-founders dr. @aaronlavelmoye and Prof. @CarlaKimLab ; Cellforma's lead asset for Idiopathic Pulmonary Fibrosis; and how a virtual cell could be instructive for cell therapy discovery. 2/3
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The RNA Society has kindly featured me in their Spotlight series. https://t.co/dWRBFTHi14 Get to know about my scientific vision on using gene regulation, RNA biology and AI/ML to build a virtual cell, as well as… 1/3
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Early-stage lung cancer, initiated by mutant KRAS, is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis @aaronlavelmoye et al @CarlaKimLab
https://t.co/0hkgyM6D5r
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NEWS - Professor Martin Howard elected as a member of @EMBO, the prestigious European Molecular Biology Organisation, in recognition of his scientific excellence. https://t.co/FcCCeOEVQD
@NorwichResearch
jic.ac.uk
Professor Martin Howard has been elected as a member of the prestigious European Molecular Biology Organisation (EMBO)…
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All the rates and associated molecular features are available as a resource. Check out the paper and SI tables!
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Online Now: Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle https://t.co/g4JpAQFIc0
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@stephenfloor @MolecularCell Congratulations to all the authors! Co-firsts: @robertietswaart @BrendanSmalec Albert Wu @karine_choquet @ErikMcshane @DrDrJowhar Chantal Gueler @Autum_BaxterKoe @_emmarosewest Becky Fu @LukeGilbertSF @stephenfloor
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🎉Our paper quantifying how RNA flows across subcellular compartments is published! 🎉 Read more in the preprint thread ⬇️ The paper contains an improved analysis of RNA flow rates and new collaborative work on DDX3X with @stephenfloor
https://t.co/fr8r1TyHpk
@MolecularCell
How does RNA flow through the cell? From their synthesis, chromatin release, nuclear export, ribosome engagement, and eventual degradation, we quantified the lives of human transcripts genome-wide. (1/7) See @BrendanSmalec and @robertietswaart ‘s preprint https://t.co/ejNAjtO7UC
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And as back-to-back with this other modelling paper with my dear friend Govind Menon! From Martin Howard group AND @ReeSvenja @robertietswaart @Bobby_Mapes, among others @JohnInnesCentre, so for me is like having twins 😍 https://t.co/bl2P6cT9st
cell.com
Mechanistic links between transcription, co-transcriptional processing, chromatin state, and epigenetic silencing remain poorly understood. Menon et al. used mathematical modeling and experiments to...
I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @MolecularCell @CarolineDeanLab @JohnInnesCentre @Miguel_Montez_ @Bobby_Mapes @XiaofengFangLab @lapassmore @MRC_LMB @La_UPM @CBGP_Madrid
https://t.co/j0eLW33ogQ
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Congrats @aaronlavelmoye @CarlaKimLab and team! Glad that GeneWalk #ML method was helpful to discover the KRAS-ITGA3-SRC axis! Thankful to have been part of this study.
Early-stage lung cancer, initiated by mutant KRAS, is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis @aaronlavelmoye et al @CarlaKimLab
https://t.co/0hkgyM6D5r
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Congratulations Stefan! So well deserved, and highly recommended for incoming students or postdocs interested in this upcoming field.
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My final paper at @BCHStemCell @harvardmed @Carlakimlab merges cancer, inflammation and cell plasticity - we identified an injury/plastic state as essential for lung repair that is co-opted by early-stage LUAD! Exciting to see similar findings from @humam_kadara et al. in Nature
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And such a cool graphical abstract by @Autum_BaxterKoe!
Online Now: A kinetic dichotomy between mitochondrial and nuclear gene expression processes https://t.co/L35wuL05Pa
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Happy to share the final version of our work! Thank you @fiddle and co-authors for this deep exploration into mitonuclear balance. 🍾 🎉
🎉Our paper on the challenges and resolution of balancing nuclear and mitochondrial gene expression is out! @ErikMcshane's deep dive into every step of mitochondrial gene expression is wild! 🎉 See tweets ⬇️ and the @MolecularCell article for much more.
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🎉Our paper on the challenges and resolution of balancing nuclear and mitochondrial gene expression is out! @ErikMcshane's deep dive into every step of mitochondrial gene expression is wild! 🎉 See tweets ⬇️ and the @MolecularCell article for much more.
Another new preprint! “Regulatory principles of human mitochondrial gene expression revealed by kinetic analysis of the RNA life cycle.” Let us walk through a day in the life of a mitochondrial RNA. @ErikMcshane led this beautiful study. (1/n) https://t.co/A4Dlx983ug
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Cellforma has been selected as a semi-finalist in the Harvard President���s Innovation Challenge! Thank you Harvard Innovation Labs for your support. @aaronlavelmoye and I look forward to participating. https://t.co/sNc9PQneYz
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@BCHStemCell @LabCentral @CarlaKimLab Thank you for the support @BCHStemCell! Looking forward to growing Cellforma with co-founders @robertietswaart and @CarlaKimLab at @LabCentral!
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