Qian_Du
@qianthefirst
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Postdoc @GrothLab @NNFCPR @GarvanInstitute @ClarkEpiLab | DNA replication | Chromatin Replication | DNA methylation | 3D genome organisation
Copenhagen
Joined December 2008
This preprint is now published with some key additions guided by an excellent review process @NAR_Open. Also grateful to our collaborators for helping progress this one across the finish line! @suscla1 @qianthefirst @Yael_David__ @zhouwanding and others! https://t.co/OX85ljomqn
academic.oup.com
Abstract. The RING E3 ubiquitin ligase UHRF1 is an established cofactor for DNA methylation inheritance. The model posits that nucleosomal engagement throu
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We are so grateful to @qianthefirst for this outstanding @NatureGenet News&Views piece highlighting our recent SPRINTER work and framing it so beautifully within the literature. A truly valuable resource! 🙏 Read it here👉 https://t.co/XqvXCkWQlI 🧵Dive into SPRINTER's work 👇
nature.com
Nature Genetics - A novel method for analyzing single-cell genomics enables direct inference of cell cycle and proliferation status, highlighting the diversity of proliferation rates in clonal...
🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 https://t.co/cd7YkBBDxo 🧵👇
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🚨So proud to present the first study from our @CCG_UCL group together with @CharlesSwanton @NnennayaKanu and led by @ojlucas with key collaboration @Ward__Sophie and fundamental support @Rija_Zaidi_ @abi_bunkum & many others Out in @NatureGenet 👇 https://t.co/cd7YkBBDxo 🧵👇
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@CPRGoesGreen created Green Labs, a guide with practical tips to make any lab or research space more sustainable. It’s a starting point to inspire everyone - students, management, and admin alike. @KabatnikSonja @labs_mann @UCPH_CPR Check it out: https://t.co/oWh7ngbiHp
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We're hiring! We have a funded postdoc available and encourage anyone interested in epigenetics and/ or gametogenesis to apply. Experience in mouse genetics/ development especially welcome! Deadline: 1 October Apply here: https://t.co/yWYqQt5YRs Please retweet!
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Honored to receive an ERC Advanced Grant to study the interaction of the chromatin landscape with 3D genome organization in Epigenetic Cell Memory 🎆 🍾 Very excited to start exploring these basic mechanisms that maintain cell identity across our lifespan 🤩 @GrothLab @UCPH_CPR
📣 Good news today for 255 outstanding research leaders who have been offered ERC Advanced Grants. The new funding, worth nearly €652 million, is part of the 🇪🇺EU’s #HorizonEurope programme. Read more 👉 https://t.co/HB95Po7e0o
#ERCAdG #FrontierResearch @EUScienceInnov
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I am over the moon to announce that the Flury lab 🤩will open in May at the Max Planck Institute for Immunobiology and Epigenetics @mpi_ie in beautiful Freiburg!☀️⛰️ I am looking forward to meeting the colleagues @mpi_ie and @UniFreiburg and to exciting collaborations!
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Just out in @NatureSMB! Our work on targeting the 3D epigenome to overcome endocrine resistance in ER+ #breastcancer. We discovered how epigenetic therapy-induced DNA methylation loss at enhancers impacts the 3D genome organization and gene regulation.
nature.com
Nature Structural & Molecular Biology - Here, the authors provide mechanistic insights into how decitabine-induced DNA hypomethylation can potentially overcome endocrine resistance in ER+...
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Last chance to apply for our #postdoc position! Deadline is Sunday!
We are recruiting a postdoc for a fully funded position in our group in beautiful Copenhagen! We encourage anyone interested in #DNAmethylation and/or #Bioinformatics to apply. Deadline: 17 September Apply here: https://t.co/nygCrG02s5 Please retweet!
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Super excited for #cshldnarep! Many amazing talks already. Looking forwards to the first poster session. If you're curious about DNA replication timing and epigenome replication, come see me at my poster tonight! #114, Biondi Hall. #cshl @cshlmeetings @GrothLab
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CPR is a truly stellar place for science! Cutting edge technologies, blue skies and translational research, collaborative spirit. Immensely sad that @novonordiskfond will close this scientific jewel. We will cherish the remaining time and #CPRlegacy 🏆
Despite our scientific success @novonordiskfond will close CPR due to new funding strategy. #forskpol #DKforsk We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵
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An assembly pathway for making heterochromatin? Yes the DAXX histone chaperone promotes H3.3K9me3 prior to nucleosome assembly! @MolecularCell
https://t.co/k07fk0Zn7n Great work by Carraro @massimocarraro7, Hammond @needfuzz and Hendriks! @thenielsenlab @GrothLab @UCPH_CPR
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Loving the talks at #EMBOevoChromo! Enjoying my first in-person conference in a long time! But this is the view from the conference room. Not distracting at all haha 😅
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@GarvanInstitute Great working with Patrick Tan and Kazu Ushijima on our invited Science review on "Mapping genomic and epigenomic evolution in cancer ecosystems" out today https://t.co/H1Qzagwm09 to celebrate the 20th anniversary of the Human Genome Project @suscla1, @AEpiA, @GarvanInstitute
science.org
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Our lab's new paper out today @CellReports showing the effects of DNA methylation loss on 3D genome integrity. Happy to have contributed Hi-C data to this amazing research. Congratulations @qianthefirst and the team!
I’m excited to share our latest publication on the importance of #DNAmethylation in maintenance of DNA replication timing and 3D genome organization. Out in @CellReports today! @ClarkEpiLab @GarvanInstitute @suscla1
#epigenetics #3Dgenome
https://t.co/Ev00kauc0E
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Truly grateful for all who have helped and collaborated along the way. @aachinger @Psy_Fer_ @DrLizCaldon @drjosephpowell @G_WCentre @martinalexsmith @c_stirzaker @kseskv A/Prof. Nicola Armstrong and the labs of Dr. Ira Deveson and Prof. Elgene Lim #AEpiA
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I’m excited to share our latest publication on the importance of #DNAmethylation in maintenance of DNA replication timing and 3D genome organization. Out in @CellReports today! @ClarkEpiLab @GarvanInstitute @suscla1
#epigenetics #3Dgenome
https://t.co/Ev00kauc0E
cell.com
Du et al. demonstrate the importance of DNA methylation in the maintenance of 3D genome regulation. They show that hypomethylation, a hallmark of cancer, is associated with the disruption of 3D...
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Excited to share our latest work, out today in @NatureComms We show that #3Dgenome interactions both within and between TADs frequently change in endocrine resistant breast cancer cells. @suscla1 @FaValdesMora @ClarkEpiLab @LizCal
nature.com
Nature Communications - Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound...
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Out in @CellCellPress yesterday, our latest work on #methylation encroachment into CpG island borders in #cancer. The dedicated efforts of @kseskv @c_stirzaker @suscla1 and all of our lab @GarvanInstitute come to fruition https://t.co/99Akoxtqp2 …. https://t.co/SzAiXlMkDC
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