Besides the GRC, we have a Wnt Signaling GRS, which provides a unique forum for doctoral and post-doctoral researchers to discuss new methods, cutting edge ideas, and pre-published data with your peers. There are a total of 10 slots for short talks at the GRS!

We have slots for short talks to be filled at both the main conference and the seminar. This is a great chance to present your work to the Wnt community and be part of our amazing line-up of speakers!

Dear #WNT & non-Wnt Researchers, Registration is still open for the Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling - register here & join us! https://t.co/ZC0STjJcIh https://t.co/wjug0tOizW

Gordon Conferences happen because Chairs and Vice Chairs raise the money needed. The Cell Contact and Adhesion GRC has an NIH grant pending with a good score, but we also need others to step up. 1/2 https://t.co/YmU29Ajutg

Looking forward to be back where everything started! - @unimib !

Great work by @SrustidharD uncoupling regeneration and tumorigenesis in intestine! 👇

Corroborating ancient Norse sagas with ancient DNA

Inflammation droves a pro-fibrotic state in heart failure via chromatin remodeling. Another masterpiece by @m_alexanian and friends @GladstoneInst

A fundamental read for every biologist - thank you @peiferlabunc !

Key people @mitsiadis @ClaudioCantu81 Martin Schwab @LaurencePirenne Chai Foong Lai At @UZH_en @ETH @liu_universitet

Nogo-A has 2 key locations: cell membrane, and endoplasmic reticulum. Which is relevant for gene expression modulation? shRNA (=inhibits all Nogo-A) vs antibody (=inhibits only cell membrane Nogo-A) --> ER-Nogo-A is the key.

Nogo-A deletion --> alters nuclear/cytoplasmic protein ratio -->does this result in gene expression changes? Yes, in particular: several genes coding for proteins important for enamel formation - Amelx, Klk4, Ambn... .- are all upregulated in the absence of Nogo-A!

We investigated further what Nogo-A may do in the dental epithelium. By pulldown+mass spec we identified many molecules involved in nuclear shuttling as direct interactors of Nogo-A. We then observed that Nogo-A deletion seems to alter nuclear/cytoplasm ratio of several proteins

We then knocked out Nogo-A in transgenic mouse models - and saw that its deletion, regardless if in all cells or only in the dental epithelium, leads to the formation of defective enamel

The initial idea was to study the role of Nogo-A in tooth innervation - yet, we immediately saw that Nogo-A is clearly expressed in the dental epithelium - and in particular, by ameloblasts, the cells that will give rise to enamel, the hardest tissue of the human body

https://t.co/gYkJ4Ki0ZS Now out on IJOS @Nature : Unexpected functions of molecules and where to find them: in this work, we studied what Nogo-A, a molecule known for its pivotal role in neural plasticity and regeneration, does during tooth development...🦷👇

From embryo to adult and back again! In our latest preprint, we introduce oncoembryology—a parallel analysis of embryonic development and cancer. With my talented PhD student @TDalessi, we explored the fascinating connections between these two processes. https://t.co/QL5PDwLgx0

Morphogens in the evolution of size, shape and patterning In this Review, Lewis Mosby, Amy Bowen and @z_hvas @TheCrick @UCL explore how morphogen-mediated patterning evolve and how theory and experiment can be interwoven to bring new perspectives: https://t.co/hDA4S509JJ

Are you interested in "skipping the postdoc" and starting your independent lab in biomedical research as a fellow? Check out the @UCSF Sandler Fellows Program! Nominations are due 1/10/2025 - more info below. https://t.co/O7w3Ac0Cvp

Old-style whiteboard discussions & explanations, although not tidy, are always the best #tooth #facethetooth #devbio