Hassan Fazilaty
@HassanFazilaty
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Molecular biologist, fascinated by embryonic development and cancer, @BaslerLab, University of Zurich @UZH_en
Zurich, Switzerland
Joined September 2012
From embryo to adult and back again!.In our latest preprint, we introduce oncoembryology—a parallel analysis of embryonic development and cancer. With my talented PhD student @TDalessi, we explored the fascinating connections between these two processes.
biorxiv.org
Reactivated embryonic programs are associated with cancer progression, yet their role and regulatory mechanisms remain poorly understood. In this study, we introduce ‘oncoembryology,’ an approach...
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Exciting new findings reveal eosinophils as key allies in the fight against colorectal cancer by blocking tumor spread. Great work by Kristina Handler, Deeksha Raju, @AlessandraGurt1 & team lead by the amazing Isabelle Arnold @lab_arnold! Honored to be a part of this study. 👇.
We are very excited to announce the release of our latest preprint exploring eosinophil dynamics in colorectal cancer (CRC)! 🧬🧫👩🔬.. Find our key findings in the comments below!.#colorectalcancer #eosinophils #spp1macrophages #tumormicroenvironment.
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Beautiful work from @KarunaMDPhD and @dana_peer labs. A fantastic step forward in understanding cancer biology—congratulations to the entire team on this impressive achievement!.
Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! A 🧵
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Feeling incredibly lucky to do what I love in beautiful Switzerland, where colors and nature’s beauty offer peaceful moments of inspiration. 🍁✨ #Grateful #AutumnInSwitzerland #ScienceInspiration
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Great work by @KassYoussef_K and many others from the @NietoAngela lab. Proud to have been a part of it! Congratulations to all🎉🎉.
Great team (more not in picture) for a great story now out @NatureCancer See how cancer cells evolve to drive dissemination and activate antitumour inflammation @NeuroAlc @ASEICAnews @RACiencias @CienciaGob @materia_ciencia @CancerCSIC
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RT @NietoAngela: Pleased to share the link to our study in @NatureCancer describing how cancer cells activate two antagonistic EMT pathways….
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RT @TDalessi: Very happy to share our newest preprint! By leveraging embryonic development, we found that SoxC transcription factors are cr….
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For a quick summary of our latest preprint, check out @TDalessi's thread! She breaks down our key findings on #Oncoembryology and the role of SoxC transcription factors in cancer and development.
Very happy to share our newest preprint! By leveraging embryonic development, we found that SoxC transcription factors are crucial drivers of colorectal cancer. Thanks @HassanFazilaty for initiating and supervising this fascinating project!.
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Also thanks to funding from @UZH_en, @snsf_ch, @CCCZ_USZ, @Swiss3RCC, @krebsliga, @GraduateCampus. Please, have a read and feel free to comment!. #CancerResearch #SoxC #ColorectalCancer #Oncoembryology.
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This was possible thanks to many, especially immense support of @KonradBasler, @BaslerLab members, @TomasValenta13, @gimoro_science, @MDBScience, collaborations with @vandenBroek_Lab and @randall_platt, and critical input from @George_Hausmann, @markrobinsonca, and many others!.
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Our oncoembryonic gene signature correlates with poor survival in colorectal cancer patients, hinting at untapped therapeutic potential!.
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SoxC transcription factors emerge as critical players in both colon development and tumorigenesis. When we blocked SoxC in experimental models, not only did tumor growth slow down, but it also stopped metastasis to the liver. Could SoxC be a key vulnerability in cancer?.
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Could the secrets of tumor growth lie in our earliest developmental stages? By systematically comparing colorectal cancer with embryonic colon development, we found some fascinating overlaps—many genes in cancer are also essential for the developing embryo!.
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Once again, microRNAs steal the spotlight!.
BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
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RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….
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RT @moorlab: Check out our lab's latest paper out in @Nature! Congrats to @cocoborrelli and everybody involved 🎉🥳.
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RT @AndreasMoor: How are cell-cell interactions governing successful metastatic colonization in the liver? Have a look at our new paper in….
nature.com
Nature - Interactions between plexin B2 on hepatocytes and sempahorins on disseminated tumour cells regulate metastatic seeding in the liver.
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One exciting aspect is discovering the link with EMT-MET dynamics and epithelialization in carcinomas. Ocaña and colleagues from @NietoAngela's lab first showed epithelialization is necessary for metastasis. 12 years later, the role of microenvironment in this process is clearer.
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We've long sought to understand the biology of metastasis. Today, in this fantastic work from @cocoborrelli and others mainly from the @moorlab, read about an elegant study explaining the mechanism of metastatic colonization. Honored to be part of this groundbreaking research!.
How are cell-cell interactions governing successful metastatic colonization in the liver? Have a look at our new paper in @nature that introduces an in vivo proximity screen to functionally test cellular interactions in a high-throughput manner. 🧵.
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